SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 8:55 pm | KEYNOTE |
| Discussion Leader: Tony Pawson (Mount Sinai Hospital, Toronto) |
7:30 pm - 8:10 pm | Keynote Speaker: Chris Marshall (Institute of Cancer Research, London)
"Small GTPase signaling pathways in cell shape and movement" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Dafna Bar Sagi (SUNY at Stony Brook) "Ras signaling: a never ending story" |
8:45 pm - 8:55 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GROWTH FACTOR SIGNALING THROUGH RECEPTOR TYROSINE KINASES |
| Discussion Leader: Stevan Hubbard (NYU Medical Center, New York) |
9:00 am - 9:25 am | Stevan Hubbard (NYU Medical Center, New York) "Structural Basis for Recruitment of Adapter Proteins to the Insulin Receptor" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Morrie Birnbaum (University of Pennsylvania) "Regulation of Lipid Metabolism by Insulin" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected Talk: Wa Xian (Baylor College of Medicine) |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:15 am | Morag Park (McGill University, Montreal) "Met receptor tyrosine kinase: intracellular trafficking, stability and transformation" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Kermit Carraway (University of California, Davis) "ErbB receptor negative regulatory mechanisms" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Selected Talk: Senthil Muthuswamy (Cold Spring Harbor Laboratory)
|
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SIGNALING MECHANISMS THROUGH SCAFFOLDS AND ADAPTOR PROTEINS |
| Discussion Leader: Roger Davis (University of Massachusetts) |
7:30 pm - 7:55 pm | Roger Davis (University of Massachusetts) "Signal transduction by stress-activated MAP kinase" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Tony Pawson (Mount Sinai Hospital, Toronto) "Signaling adaptors for cytoskeletal organization and cell polarity" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | John Scott (Oregon Heath & Science University) "Cell Signaling in Space and Time" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Gary Koretzky (University of Pennsylvania) "Adapters as regulators of hematopoietic cell development and function" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SIGNAL INTEGRATION I |
| Discussion Leader: Melanie Cobb (University of Texas Southwestern Medical Center) |
9:00 am - 9:25 am | Melanie Cobb (University of Texas Southwestern Medical Center) "Roles of MAP3 Kinases in Stress Responses" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Dario Alessi (Dundee University) "Regulation and Function of the WNK1protein kinase" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected Talk: Maria-Magdalena Georgescu (University of Texas MD Anderson Cancer) |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:15 am | John Blenis (Harvard Medical School, Massachusetts) "Nutrient- and growth factor-dependent regulation of mTORC1, protein synthesis and cell growth" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Marc Vidal (Harvard University, Center for Cancer Systems Biology) "Interactome Networks" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Selected Talk: Cathy Savage-Dunn (Queens College, CUNY) |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TGF-3 FAMILY OF GROWTH FACTOR RECEPTORS |
| Discussion Leader: Liliana Attisano (University of Toronto) |
7:30 pm - 7:55 pm | Liliana Attisano (University of Toronto) "An integrated approach to define the Wnt interactome" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Caroline Hill (Institute of Cancer Research, London) "Regulation of the TGF-beta/Smad signaling pathway" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Jeff Wrana (Mount Sinai Hospital, Toronto) "TBA" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Ying Zhang (NIH) "Smad3 signaling and tumor suppression" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FROM MOLECULES TO NETWORKS |
| Discussion Leader: Jim Ferrell (Stanford University) |
9:00 am - 9:25 am | Jim Ferrell (Stanford University) "Positive feedback, bistability, and cell cycle oscillations" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | David Barford (Institute of Cancer Research, London) "Structural analysis of AKAPs" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected Talk: Kurt Ballmer-Hofer (Paul Sherrer Institut) |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:15 am | Doug Lauffenburger (MIT) "Quantitative Experiment and Computational Modeling Approaches for Relating Signaling Network Activities to Cell Behavioral Responses" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Mike Yaffe (MIT) "Dynamics of kinase-substrate interactions" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Selected talk: Kathrin Kirsch (Boston University School of Medicine) |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | G-PROTEIN SIGNALING AND CYTOSKELETAL DYNAMICS |
| Discussion Leader: Klaus Hahn (UNC - Chapel Hill) |
7:30 pm - 7:55 pm | Klaus Hahn (UNC -Chapel Hilll) "Rapid generation of biosensors to report activation of endogenous proteins applications in growth factor and motility signaling" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Richard Marais (Institute of Cancer Research, London) "BRAF in human cancer: biology and therapeutic opportunities" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Sheila Thomas (Harvard University) "Integrin Independent Functions of Focal Adhesion Proteins" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Bruce Mayer (University of Connecticut Health Center) "Coupling growth factor signalling to the actin cytoskeleton via Nck adaptors" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HIGH THROUGHPUT ANALYSIS/RNAi SCREEN AND PROTEOMICS |
| Discussion Leader: Tobias Meyer (Stanford University) |
9:00 am - 9:25 am | Tobias Meyer (Stanford University) "A Modular Structure for Mammalian Signal Transduction Networks" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Forest White (MIT) "Quantitative Proteomic Analysis of Receptor Tyrosine Kinase Signaling Networks" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:55 am | Gavin MacBeath (Harvard University) "System-based approaches to studying RTK signaling using protein microarrays" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | David Sabatini (MIT) "mTOR regulation of growth and proliferation" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 | Selected Talk: David Foster (Hunter College of CUNY) |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Selected Talk: Susana Parathath (Memorial Sloan Kettering Cancer Center) |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEURONAL SIGNALING MECHANISMS |
| Discussion Leader: Elena Pasquale (The Burnham Institute, California) |
7:30 pm - 7:55 pm | Elena Pasquale (The Burnham Institute, California) "Dual role of the EphB4 receptor in breast cancer cells" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Ira Daar (NCI, NIH) "EphrinB1 control of cell movement: the DvI is in the details" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Moses Chao (NYU Medical Center) "Unique features of neurotrophin receptor signaling" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | David Ginty (Johns Hopkins University School of Medicine) "Neurotrophin signaling in the developing and adult nervous system" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |