| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MEGAKARYOCYTE BIOLOGY |
| Discussion Leader: Andrew Leavitt (University of California, San Francisco) |
| 7:30 pm - 8:00 pm | Kenneth Kaushansky (University of California, San Diego)
Signaling in megakaryocytes |
| 8:00 pm - 8:30 pm | Katya Ravid (Boston University)
Computer modeling of megakaryocyte gene expression |
| 8:30 pm - 9:00 pm | Joseph Italiano (Harvard University)
Platelet production by megakaryocytes |
| 9:00 pm - 9:30 pm | Paula Tracy (University of Vermont)
Factor V-Megakaryocyte interaction |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HOMEOSTASIS IN VIVO |
| Discussion Leader: William Fay (University of Michigan) |
| 9:00 am - 9:30 am | Nigel Mackman (Scripps Research Institute)
Tissue factor biology in vivo |
| 9:30 am - 10:00 am | Barbara Furie (Harvard Medical School)
PSGL-1 and thrombus formation |
| 10:00 am - 10:40 am | Coffee Break and Conference Photo |
| 10:40 am - 11:10 am | Hartmut Weiler (Blood Center of Southeastern Wisconsin)
Regulation of hemostasis |
| 11:10 am - 11:40 am | Jay Degen (Cincinnati Children's Hospital)
Fibrinogen functions in vivo |
| 11:40 am - 12:10 pm | Peter Newman (Blood Center of Southeastern Wisconsin)
Phenotypic analysis of the PECAM-1-deficient mouse |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session A |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PLATELET REGULATION AND RESPONSES |
| Discussion Leader: Michael Berndt (Monash University, Australia) |
| 7:30 pm - 7:55 pm | Charles Abrams (University of Pennsylvania)
Lipid mediators in platelet signaling |
| 7:55 pm - 8:20 pm | Leslie Parise (University of North Carolina)
CIB regulation of GPIIb/IIIa |
| 8:20 pm - 8:45 pm | David Calderwood (Yale University)
Regulation of integrin activation by talin |
| 8:45 pm - 9:10 pm | Kenneth Clemetson (University of Bern, Switzerland)
Control of GPV expression |
| 9:10 pm - 9:30 pm | Sanford Shattil (University of California, San Diego)
The molecular basis of outside-in integrin signaling |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | STRUCTURE/FUNCTION IN BLOOD COAGULATION |
| Discussion Leader: Sriram Krishnaswamy (University of Pennsylvania) |
| 9:00 am - 9:30 am | Wolfram Ruf (Scripps Research Institute)
Tissue factor cell biology |
| 9:30 am - 10:00 am | George Broze (Washington University, St. Louis)
TFPI alpha and beta |
| 10:00 am - 10:20 am | Coffee Break |
| 10:20 am - 10:50 am | Michael Kalafatis (Cleveland State University)
Cofactor directed catalysis during prothrombin activation |
| 10:50 am - 11:20 am | Philip Fay (University of Rochester)
Structure/function of Factor VIII |
| 11:20 am - 11:50 am | Darrell Stafford (University of North Carolina)
Regulation of carboxylation |
| 11:50 am - 12:10 pm | Stephen Everse (University of Vermont)
The Structure of Factor Vai: Functional Implications |
| 12:10 pm - 12:30 pm | Klaus Preissner (Justus-Liebig University, Giessen, Germany)
Extracellular RNA and the Initiation of Blood Clotting |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session A (continued) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | VON WILLEBRAND FACTOR and TTP |
| Discussion Leader: Bob Montgomery (Blood Center of Southeastern Wisconsin) |
| 7:30 pm - 8:00 pm | Thomas Diacovo (Washington University, St. Louis)
vWF/GPIb interactions |
| 8:00 pm - 8:30 pm | J. Evan Sadler (Washington University, St. Louis)
vWF structure and ADAMTS13 cofactors |
| 8:30 pm - 9:00 pm | David Ginsburg (University of Michigan)
ADAMTS13 deficiency in mice and humans |
| 9:00 pm - 9:30 pm | Jing-Fei Dong (Baylor College of Medicine)
ADAMTS13 function under flow |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENETICS AND GENETIC APPROACHES TO THROMBOSIS |
| Discussion Leader: Paul Bray (Baylor College of Medicine) |
| 9:00 am - 9:30 am | Pudur Jagadeeswaran (University of Texas)
Zebrafish Model: Genetics of Hemostasis and Thrombosis |
| 9:30 am - 10:00 am | Lawrence Leung (Stanford University)
Gene expression in endothelium |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Steve Watson (University of Oxford, United Kingdom)
Platelet proteomics |
| 11:00 am - 11:30 am | Niamh Moran (Royal College of Surgeons in Ireland)
Platelet enonomics |
| 11:30 am - 12:00 pm | Qing Wang (Cleveland Clinic Foundation)
Genes for thrombosis and MI |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOT TOPICS |
| Discussion Leader: Jose Lopez (Baylor College of Medicine) |
| 7:30 pm - 7:45 pm | Fern Tablin (UC Davis)
Platelet membrane lipid dynamics |
| 7:45 pm - 8:00 pm | Vinod Vijayan (Baylor College of Medicine)
Protein phosphatase 1 associates with the integrin α subunit and regulates signaling |
| 8:00 pm - 8:15 pm | Susan Smyth (University of North Carolina)
Src-dependent signaling is necessary for ß2-integrin function and firm adhesion of PMNs tethered to platelets by P-selectin under physiologic flow |
| 8:15 pm - 8:30 pm | Beatrice Haimovich (Robert Wood Johnson Medical School)
The phosphorylation of vinculin on two tyrosine residues, mediated by src kinases, affects cell spreading |
| 8:30 pm - 8:45 pm | Denise Jackson (Austin Research Institute)
The tetraspanin superfamily member, CD151 regulates outside-in integrin αIIbß3 signalling and platelet function |
| 8:45 pm - 9:00 pm | Elizabeth Gardiner (Monash University)
Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase |
| 9:00 pm - 9:15 pm | James Huntington (University of Cambridge)
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin |
| 9:15 pm - 9:30 pm | John McVey (Imperial College)
Reduced expression of ABCA1 and a novel missense mutation that results in altered protein trafficking underlie Scott syndrome |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PLATELET AND VASCULAR BIOLOGY: STRUCTURE AND FUNCTION |
| Discussion Leader: Skip Brass (University of Pennsylvania) |
| 9:00 am - 9:30 am | Denisa Wagner (Harvard Medical School)
Platelet adhesion receptors in vascular biology |
| 9:30 am - 10:00 am | Jose Lopez (Baylor College of Medicine)
Lipid rafts, hemostasis and thrombosis |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Robert Liddington (Burnham Institute)
Structure of cytoskeletal proteins |
| 11:00 am - 11:30 am | Olga Vinogradova (Cleveland Clinic Foundation)
Integrin cytoplasmic tails |
| 11:30 am - 12:00 pm | Joel Bennett (University of Pennsylvania)
Regulation of integrin activation |
| 12:00 pm - 12:20 pm | Stephen Lam (University of Illinois at Chicago)
Talin Interaction with the ß3 Cytoplasmic Tail |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session B (continued) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | VASCULAR RESPONSES |
| Discussion Leader: Richard Hynes (Massachusetts Institute of Technology) |
| 7:30 pm - 8:00 pm | Mark Ginsberg (University of California, San Diego)
Integrin α4ß biology |
| 8:00 pm - 8:30 pm | Cheryl Hillery (Medical College of Wisconsin)
Vasopathology of sickle cell disease |
| 8:30 pm - 9:00 pm | Mark Kahn (University of Pennsylvania)
Control of lymphangiogenesis |
| 9:00 pm - 9:30 pm | Thomas Deuel (Scripps Research Institute)
Control of angiogenesis |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
