Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanistic Perspectives on the Pathophysiology of Hemostasis
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Hemostatic Plug Structure and Function: Lessons From in Vivo Imaging"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Connecting Atherosclerosis, Thrombosis and Bleedingdisorders Through Lipoproteins"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Rethinking Hemostasis Through a Molecular Lens: Advancing from Discovery Toward Precision Hemostasis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Vascular Integrity
9:00 am - 9:25 am
"Mechanisms and Targets at the Intersection of Platelet Procoagulant and Hemostatic Activity"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Platelet-like-Particles for Hemostasis and Regenerative Medicine"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
"Thrombosis as a Local Driver of Vascularity and Endothelial Integrity"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"The Role of Fibrin Mechanics in Hemostasis"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Platelet-inspired Trojan Horses and Drones: From Hemostasis to Targeted Drug Delivery"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dysregulation of Coagulation in Diseases
7:30 pm - 7:55 pm
"Metabolic–Hormonal Crosstalk in Thrombosis: Obesity and Estrogen Converge on Protein S Regulation"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Thromboinflammatory Crosstalk in Cardiovascular and Infectious Diseases"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Translational Approaches to Acute Traumatic Coagulopathy and Thromboinflammation"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bridging Autoimmunity and Thrombosis
9:00 am - 9:25 am
"Complement’s role in HIT Thrombosis"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Building Data with Models: Virtual Clinical Trials in Hemostasis"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Toward an Antiphospholipid Antibody Atlas: A Precision Medicine Approach to APS"
11:10 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Inflammation in Cellular and Molecular Mechanisms of Venous Thromboembolism"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Accelerating Venous Thrombus Resolution Through Enhanced Macrophage-Mediated Efferocytosis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hemostasis and Neurologial Diseases
7:30 pm - 7:55 pm
"Factor VIII Deficiency and the Brain: Mechanisms of Cognitive Dysfunction in Hemophilia A"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Beyond the clot: Immunothrombosis in Stroke"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Targeting the Vascular System to Ameliorate Alzheimer’s Disease Pathologies"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sensing the Extracellular Environment
9:00 am - 9:25 am
"Novel Roles for the Thrombin Receptor PAR1 in Modulating Lung Lymphatic Vascular Function"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"TMEM16-Mediated Endothelial Procoagulant Membrane Contributes to the Pro-Thrombotic State"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"EPCR at the Interface of Coagulation and Endothelial Homeostasis in Sickle Cell Disease"
11:10 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Regulation of Coagulation and Fibrinolysis During COVID19-Associated Coagulopathy"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Beyond Clotting: Immune Profiling of Coagulation Factor Replacement in Hemophilia"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Platelets and Their Neighbors
9:00 am - 9:25 am
"Cutting and Shaping Platelet Functionality"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"A Clot to Remember: Reciprocal Regulation of Coagulation and Immune Memory"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Personalising Anti-Platelet Therapy"
11:10 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Membrane Cytoskeleton Interaction in Platelet Production and Function"
11:50 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Megakaryocyte and Platelet Immunometabolism in Systemic Inflammatory Diseases"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Integrating Experimental and Clinical Perspectives in Hemostasis Research
7:30 pm - 8:15 pm
"Von Willebrand disease: The Centenarian Takes Center Stage"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"From Monoclonal Antibody to Crystal Structure to Clinical Trial: The Zalunfiban (RUC-4) Story"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure