| SUNDAY |
| 2:00 - 9:00 | Arrival and check-in |
| 6:00 | Dinner |
| 7:30 - 10:00 | Genetics and physiology of hormonal and neural peptide synthesis and processing. |
| Betty Eipper - Discussion Leader |
| 7:30 - 7:45 | Gary Thomas and GRC Staff, Welcome |
| 7:45 - 8:15 | Don Steiner (University of Chicago)
“Hormone Biosynthesis and Secretion in the Post-Genomics Era” |
| 8:15 - 8:45 | Gary Ruvkun (Harvard University)
“Genetics of Endocrine Homeostasis in Caenorhabditis elegans” |
| 8:45 - 9:15 | John Pintar (Rutgers University)
“Regulation of Production of Endogenous Opioid Peptides by Different Classes of Post-Translational Processing Enzymes and their Chaperones” |
| 9:15 - 9:45 | Miles Brennan (Eleanor Roosevelt Institute)
“Integration of Body Homeostasis by POMC Peptides” |
| 10:00 | Reception |
| MONDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 - 12:30 | Role of processing enzymes in human physiology and disease. |
| Jan Christian - Discussion Leader |
| 9:00 - 9:30 | Nabil Seidah (Clinical Research Institute of Montreal)
“Structure-Function, Cell Biology and Pathological Implications of the PCs and SKI-1/S1P” |
| 9:30 - 10:00 | Mike Wolfe (Harvard University)
“Role of g-Secretase in Signaling and Alzheimer’s Disease” |
| 10:00 - 10:30 | Han-Mou Tsai (Albert Einstein College of Medicine)
“Proteolytic Processing of von Willebrand factor; a Novel Antithrombotic Mechanism” |
| 10:30 - 11:15 | Coffee/Group Picture |
| 11:15 - 11:45 | Michael Blackman (National Institute for Medical Research, London)
“Subtilisins and Surface Proteins in Red Blood Cell Invasion by the Malaria Parasite” |
| 11:45- 12:00 | Kami Kim (Albert Einstein College of Medicine)
"Role of Toxoplasma gondii subtilases in organellar biogenesis and intravaculor growth" |
| 12:00 - 12:15 | John Creemers (University of Leuven)
"Impaired small intestinal function associated with loss-of-function mutations in the human PC1 gene" |
| 12:15 - 12:30 | Daniel Bassi (Fox Chase Cancer Center)
"Proprotein convertases enhance the aggressive behavior of cancer cells" |
| 12:30 - 1:30 | Lunch |
| 1:30 - 4:00 | Free Time |
| 4:00 - 6:00 | Poster Session 1 |
| 6:00 | Dinner |
| 7:30 - 9:30 | Biochemistry and structural analysis of proprotein processing enzymes. |
| Michel Chrétien - Discussion Leader |
| 7:30 - 8:00 | Ujwal Shinde (OHSU)
“Protease Folding and Activation Modulated by Intramolecular Chaperones” |
| 8:00 - 8:30 | Bob Fuller (University of Michigan)
"High-Affinity Selective Inhibition of Proprotein Processing Proteases" |
| 8:30 - 9:00 | Iris Lindberg (Louisiana State University Health Sciences Center)
“Convertase Binding Proteins” |
| 9:00 - 9:15 | Macie Walker (University of Oregon)
"Furin regulates pharyngeal cartilage development in zebrafish" |
| 9:15 - 9:30 | Gail Cornwall (Texas Tech University Health Sciences Center)
"CRES (Cystatin-Related Epididymal Spermatogenic) inhibits the serine prohormone convertase 2" |
| TUESDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 - 12:30 | Structure and regulation in protein sorting and localization. |
| Tom Martin - Discussion Leader |
| 9:00 - 9:30 | Bill Balch (Scripps Research Institute)
“Regulation of Membrane Traffic by Ras Superfamily GTPases” |
| 9:30 - 10:00 | Frances Brodsky (UCSF)
“Clathrin-Mediated Membrane Traffic in Specialized Tissues” |
| 10:00 - 10:30 | Juan Bonifacino (NIH)
“Sorting of Lysosomal Hydrolases at the TGN” |
| 10:30 - 11:00 | Coffee |
| 11:00 - 11:30 | Judith Klumperman (University of Utrecht)
“Vesicular tubular clusters between ER and Golgi regulate Presenilin I levels in pre- and post-Golgi pools” |
| 11:30 - 12:00 | Mark Stamnes (University of Iowa)
“Regulation of the actin cytoskeleton during vesicle formation at the Golgi” |
| 12:00 - 12:15 | Oleg Varlamov (Memorial Sloan-Kettering Cancer Center)
"i-SNAREs: Negative regulators of membrane fusion in the Golgi" |
| 12:15 - 12:30 | Anastasia Blagoveshchenskaya (Vollum Institute)
“Connecting Furin Trafficking and HIV-1 Immunoevasion” |
| 12:30 - 1:30 | Lunch |
| 1:30 - 4:00 | Free Time |
| 4:00 - 6:00 | Poster Session 1 |
| 6:00 | Dinner |
| 7:30 - 9:45 | Golgi structure, dynamics, and sorting. |
| Sharon Tooze - Discussion Leader |
| 7:30 - 8:00 | Kathryn Howell (University of Colorado Health Sciences Center)
“Structure/Function Relationship of theß-cell Golgi Complex” |
| 8:00 - 8:30 | Vytas Bankaitis (University of North Carolina, Chapel Hill)
“Phosphatidyl Inositol Transfer Protein Function in the Mouse” |
| 8:30 - 8:45 | Peter Mayinger (University of Heidelberg)
"Role of the yeast Sac1 phosphoinositide phosphatase in Golgi and endosomal trafficking" |
| 8:45 - 9:15 | Antonella De Matteis (Consorzio Mario Negri Sud, Chieti, Italy)
“Phosphoinositides and the Golgi Complex: the Role of PtIns4P” |
| 9:15 - 9:45 | Dennis Shields (Albert Einstein College of Medicine)
“Maintaining the Structure of the Golgi Apparatus: the Role of Phosphoinositides” |
| WEDNESDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 - 12:30 | Formation of stimulus-responsive compartments. |
| Kathryn Howell - Discussion Leader |
| 9:00 - 9:30 | Mickey Marks (University of Pennsylvania)
“Control of Organelle Biogenesis by PC-Dependent Cleavage” |
| 9:30 - 10:00 | Dick Mains (University of Connecticut) “Routing, Connecting the Inside and Outside of Peptide Granules” |
| 10:00 - 10:30 | Gary Banker (OHSU)
"Protein Trafficking in Polarized Nerve Cells" |
| 10:30 - 11:00 | Coffee Break |
| 11:00 - 11:30 | Hans-Hermann Gerdes (University of Heidelberg)
“Actin-Dependent Transport of Secretory Granules” |
| 11:30 - 12:00 | Keith Joiner (Yale University)
“Cholesterol homeostasis and membrane transport in Toxoplasma and Plasmodium” |
| 12:00 - 12:15 | Dan Cutler (Unversity College, London)
"Biogenesis of Weibel-Palade Bodies" |
| 12:15 - 12:30 | Michele Solimena (Medizinische Fakultat der TU Dresden)
"Stimulation-induced biosynthesis and degradation of the secretory granule protein ICA512 in ß-cells" |
| 1:30 - 4:00 | Free Time |
| 4:00 - 6:00 | Poster Session 2 |
| 6:00 | Dinner |
| 7:30 - 9:30 | Targeting to secretory granules and synaptic vesicles. |
| John Hutton - Discussion Leader |
| 7:30 - 8:00 | Peter Arvan (Albert Einstein College of Medicine)
“Lumenal protein trafficking into constitutive, constitutive-like, and regulated secretory pathways” |
| 8:00 - 8:30 | Y. Peng Loh (NIH)
“Chromogranin A Controls Dense Core Granule Biogenesis in Neuroendocrine Cells” |
| 8:30 - 9:00 | Bob Edwards (UCSF)
“Targeting of Transporters to the Regulated Pathway” |
| 9:00 - 9:30 | Sharon Tooze (ICRF, London)
“The role of snares in secretory granule maturation” |
| THURSDAY |
| 7:30 - 8:30 | Breakfast |
| 9:00 - 12:30 | New approaches to peptide diversity. |
| Nabil Seidah - Discussion Leader |
| 9:00 - 9:30 | Paul Taghert (Washington University)
“Specification of the Pro-Secretory Phenotype in Neuroendocrine Lineages by bHLH Proteins” |
| 9:30 - 10:00 | Lloyd Fricker (Albert Einstein College of Medicine)
“Quantitative proteomics of neuropeptides in animal models with defective processing enzymes” |
| 10:00 - 10:30 | Masashi Yanigasawa (University of Texas Southwestern Med. Ctr.)
“Sleep, feeding and neuropeptides” |
| 10:30 - 11:00 | Coffee Break |
| 11:00 - 11:30 | Christine Li (Boston University)
“The Function of the flp Neuropeptide Gene Family in Caenorhabditis elegans” |
| 11:30 - 12:00 | Rainer Reinscheid (University of California, Irvine)
"The Search for Novel Neuropeptides and Hormones" |
| 12:00 - 12:15 | Robert Day (University of Sherbrooke)
"A novel RNA splicing protein is involved in secretory granule biogenesis" |
| 12:15 - 12:30 | Henry Pelish (Harvard University)
"Secramine: A novel inhibitor of export from the Golgi apparatus discovered through biomimetic diversity-oriented synthesis and screening" |
| 1:30 - 4:00 | Free Time |
| 4:00 - 5:00 | Poster Session 2 |
| 5:00 - 6:00 | Awards, Business Meeting and 2004 Vice-Chair Election |
| 6:00 | Dinner |
| 7:30 - 9:30 | Mechanisms and regulation of exocytosis. |
| Peter Arvan - Discussion Leader |
| 7:30 - 8:00 | Tom Martin (University of Wisconsin)
“Mechanisms of Regulated Exocytosis Distinct to Dense-Core Vesicles” |
| 8:00 - 8:30 | Sandy Bajjalieh (University of Washington)
“Modulation of Calcium-Regulated Secretion by SV2” |
| 8:30 - 9:00 | Edwin Levitan (University of Pittsburgh)
“Secretory vesicle dynamics and neuropeptide release” |
| 9:00 - 9:15 | Robert Chow (University of Southern California)
"Functional and spatial segregation of secretory vesicles according to age" |
| 9:30 - | Fricker's Fabulous Follies and Dance Party |
