Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Keynote Session: Genomic Approaches to Understanding Hormone Dependent Cancer
Discussion Leaders: Geoffrey Greene (University of Chicago, USA) and Mathieu Lupien (Princess Margaret Cancer Centre, Canada)
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7:40 pm - 8:20 pm |
Elaine Mardis (Institute for Genomic Medicine, Nationwide Children's Hospital, USA)
"Breast and Endometrial Cancer Genomics: Discovery to Clinic"
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8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 9:10 pm |
Rene Bernards (Netherlands Cancer Institute, The Netherlands)
"Finding Vulnerabilities of Drug-Resistant Cancer"
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9:10 pm - 9:20 pm |
Discussion
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9:20 pm - 9:30 pm |
General Discussion
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Monday
|
7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Nuclear
Receptor Function and Co-Factors
Discussion Leaders: Qianben Wang (Ohio State University, USA) and Jennifer Richer (University of Colorado Anschutz Medical Campus, USA)
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9:00 am - 9:20 am |
Zeynep Madak Erdogan (University of Illinois at Urbana-Champaign, USA)
"Systems Biology of Obesity-Associated ER(+) Breast Cancer"
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9:20 am - 9:30 am |
Discussion
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9:30 am - 9:50 am |
Inez Rogatsky (Hospital for Special Surgery / Weill Cornell Medicine, USA)
"The GR:GRIP1 Axis in Macrophages and Inflammation"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Eric Chang (Baylor College of Medicine, USA)
"Direct Regulation of Estrogen Receptor-α Transcriptional Activity by NF1"
|
10:10 am - 10:20 am |
Discussion
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10:20 am - 10:30 am |
George Muscat (The University of Queensland, Australia)
"Estrogen Signalling Regulates Protein Arginine Methyltransferase 6 Expression in Breast Cancer: Insights into Drug Resistance"
|
10:30 am - 10:40 am |
Discussion
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10:40 am - 11:10 am |
Coffee Break
|
11:10 am - 11:30 am |
Donald McDonnell (Duke University, USA)
"Identification of Targetable Proteins and Processes Downstream of Steroid Receptors in Breast and Prostate Cancers"
|
11:30 am - 11:40 am |
Discussion
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11:40 am - 11:50 am |
Stacey Joosten (Netherlands Cancer Institute, The Netherlands)
"Characterizing Steroid Hormone Receptor Overlap in (Fe)male Breast Cancer Tissue"
|
11:50 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Irida Kastrati (University of Illinois at Chicago, USA)
"NFkB Pathway Is a Key Determinant of Tamoxifen Tolerance and Recurrence in Breast Cancer"
|
12:10 pm - 12:15 pm |
Discussion
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12:15 pm - 12:25 pm |
Ahmed Basudan (University of Pittsburgh, USA)
"ESR1 Copy Number Amplifications and Imbalance in Metastatic Breast Cancer"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 9:30 pm |
Tumor Microenvironment
Discussion Leaders: Suzanne Conzen (The University of Chicago, USA) and Luke Selth (University of Adelaide, Australia)
|
7:30 pm - 7:50 pm |
Senthil Muthuswamy (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Cell Polarity Protein Lethal Giant Larvae in ER+ Breast Cancer"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Pepper Schedin (Oregon Health and Science University, USA)
"Normal Mucosal Biology and Tissue Involution Cooperate to Drive Breast Cancer Metastasis"
|
8:20 pm - 8:30 pm |
Discussion
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8:30 pm - 8:40 pm |
David Lung (McArdle Laboratory of Cancer Research, University of Wisconsin-Madison, USA)
"Bone Marrow Stromal Cell Factors Activate ER Transcriptional Responses Without Requiring ER"
|
8:40 pm - 8:50 pm |
Discussion
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8:50 pm - 9:00 pm |
Claire Nash (Research Institute of the McGill University Health Centre, Canada)
"Genome-Wide Analysis of AR Binding and Transcriptomic Analysis of Primary Prostate Tumour Stroma and Prostate Mesenchyme"
|
9:00 pm - 9:10 pm |
Discussion
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9:10 pm - 9:20 pm |
Matthew Sikora (University of Colorado Anschutz Medical Campus, USA)
"Delineating the ER/WNT4 Signaling Pathway Mediating Proliferation and Survival in Lobular Carcinoma"
|
9:20 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Functional Genomics, Non-Coding RNA and Epigenomics
Discussion Leaders: Felix Feng (University of California, San Francisco, USA) and Charlotte Bevan (Imperial College London, United Kingdom)
|
9:00 am - 9:20 am |
Matthew Freedman (Dana-Farber Cancer Institute, USA)
"Identification and Characterization of a Novel Androgen Receptor Enhancer in Advanced Prostate Cancer"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Rachael Natrajan (The Institute of Cancer Research, London, United Kingdom)
"Alternative Splicing as a Driver of ER+ Breast Cancer"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Jay Gertz (University of Utah, USA)
"Combinatorial Control of Gene Regulation by Estrogen Receptor Alpha Bound Enhancers"
|
10:10 am - 10:20 am |
Discussion
|
10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:10 am |
Scott Tomlins (University of Michigan, USA)
"Prostate Cancer Progression from an AR-Dependent to Independent Disease"
|
11:10 am - 11:20 am |
Discussion
|
11:20 am - 11:40 am |
Wilbert Zwart (Netherlands Cancer Institute, The Netherlands)
"Epigenetic Profiling in Prostate Cancer: Classifiers, Biomarkers and Mechanisms"
|
11:40 am - 11:50 am |
Discussion
|
11:50 am - 12:00 pm |
Claire Fletcher (Imperial College London, United Kingdom)
"A Novel High-Throughput Screening Approach Identifies Androgen Receptor-Modulatory MicroRNAs and New Therapeutic Targets in Prostate Cancer"
|
12:00 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:20 pm |
Ruth Keri (Case Western Reserve University, USA)
"Targeting Mitosis-Associated Gene Expression in Breast Cancer"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Mutational Changes in Hormone Dependent Cancer
Discussion Leaders: Sarat Chandarlapaty (Memorial Sloan Kettering Cancer Center, USA) and Scott Dehm (University of Minnesota, USA)
|
7:30 pm - 7:50 pm |
Adrian Lee (University of Pittsburgh Cancer Institute, USA)
"Mutational Evolution in Hormone-Independent Breast Cancer"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Doug Levine (Perlmutter Cancer Center, NYU Langone Medical Center, USA)
"Capitalizing on the Mutational Complexity of Gynecologic Tumors"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Chris Sweeney (Dana-Farber Cancer Institute, USA)
"Will Biomarkers Lead to Optimal Management of Prostate Cancer?"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:10 pm |
Rinath Jeselsohn (Dana Farber Cancer Institute, USA)
"Allele-Specific Functions and Therapeutic Vulnerabilities of ESR1 Activating Mutations"
|
9:10 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Suzanne Fuqua (Baylor College of Medicine, USA)
"The Y537S ESR1 Mutation Regulates EMT and Is a Metastatic Driver in ER-Positive Breast Cancer"
|
9:25 pm - 9:30 pm |
Discussion
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Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Pathway Cross-Talk
Discussion Leaders: Ganesh Raj (University of Texas Southwestern Medical Center, USA) and Wayne Tilley (University of Adelaide / Hanson Institute, Australia)
|
9:00 am - 9:20 am |
Karen Knudsen (Sidney Kimmel Cancer Center, Thomas Jefferson University, USA)
"Targeting Hormone-DNA Repair Crosstalk"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Daniel Frigo (University of Houston, USA)
"Targeting Prostate Cancer Metabolism"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Theresa Hickey (University of Adelaide, Australia)
"Applying the Endocrine Brakes to Estrogen-Driven Breast Cancers"
|
10:10 am - 10:20 am |
Discussion
|
10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:10 am |
Daniel Gioeli (University of Virginia, USA)
"Take the DDR to the AR to Get Pca"
|
11:10 am - 11:20 am |
Discussion
|
11:20 am - 11:40 am |
Carol Sartorius (University of Colorado Anschutz Medical Campus, USA)
"Mechanisms of Progesterone Receptor Mediated Growth Suppression of Breast Cancer Patient-Derived Xenografts"
|
11:40 am - 11:50 am |
Discussion
|
11:50 am - 12:00 pm |
Carol Lange (University of Minnesota, USA)
"Oncogenic Actions of GR-Mediated Stress Signaling in Triple Negative Breast Cancer"
|
12:00 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:20 pm |
Hillary Stires (Georgetown University, USA)
"Androgen Receptor and Endocrine Resistance in Invasive Lobular Breast Carcinoma"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Cancer Subtypes
Discussion Leaders: Alex Swarbrick (Garvan Institute of Medical Research, Australia) and Christopher Morrow (AstraZeneca, United Kingdom)
|
7:30 pm - 7:50 pm |
Christina Curtis (Stanford University, USA)
"Learning the Dynamics and Signatures of Treatment Response in Breast Cancer"
|
7:50 pm - 8:00 pm |
Discussion
|
8:00 pm - 8:20 pm |
Jorge Reis-Filho (Memorial Sloan Kettering Cancer Center, USA)
"Molecular Heterogeneity in Breast Cancer Subtypes"
|
8:20 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:50 pm |
Massimo Loda (Dana Farber Cancer Institute / Harvard Medical School, USA)
"Inhibition of De Novo Lipogenesis Suppresses Growth via Modulation of Androgen Receptor Signaling in Castration-Resistant Prostate Cancer"
|
8:50 pm - 9:00 pm |
Discussion
|
9:00 pm - 9:20 pm |
Scott Cramer (University of Colorado, USA)
"Cross-Talk Between Androgen Receptor and CHD1: The REST of the Story"
|
9:20 pm - 9:30 pm |
Discussion
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Modelling Cancer and Novel Therapeutics
Discussion Leaders: Elgene Lim (Garvan Institute of Medical Research, Australia) and Sylvie Mader (Universite de Montreal, Canada)
|
9:00 am - 9:20 am |
Rachel Schiff (Baylor College of Medicine, USA)
"The Role of FOXA1 in ER+ Breast Cancer Endocrine Resistance and Metastasis"
|
9:20 am - 9:30 am |
Discussion
|
9:30 am - 9:50 am |
Alana Welm (University of Utah, USA)
"PDX Models for Breast Cancer"
|
9:50 am - 10:00 am |
Discussion
|
10:00 am - 10:10 am |
Alison Harrod (Imperial College London, United Kingdom)
"Modelling Estrogen Receptor Mutations in Metastatic Breast Cancer"
|
10:10 am - 10:20 am |
Discussion
|
10:20 am - 10:50 am |
Coffee Break
|
10:50 am - 11:10 am |
Cathrin Brisken (Ecole Polytechnique Federale de Lausanne, Switzerland)
"Estrogen Receptor Positive Breast Cancer: How the Microenvironment Matters"
|
11:10 am - 11:20 am |
Discussion
|
11:20 am - 11:40 am |
Alex Gaither (Novartis, USA)
"Novel Clinical Agents for Hormone Dependent Breast Cancer"
|
11:40 am - 11:50 am |
Discussion
|
11:50 am - 12:00 pm |
Liz Caldon (Garvan Institute of Medical Research, Australia)
"Polyploidy Is an Early Change in the Acquisition of Endocrine Resistance"
|
12:00 pm - 12:10 pm |
Discussion
|
12:10 pm - 12:20 pm |
Alexandra Blee (Mayo Clinic Graduate School of Biomedical Sciences, USA)
"Understanding TMPRSS2-ERG Fusion-Positive Prostate Cancer: Interaction with Gain of Function p53 in Anti-Androgen Resistant Tumors"
|
12:20 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 5:30 pm |
Poster Session
|
5:30 pm - 7:30 pm |
Keynote Session: Chemistry to Biology and Novel Approaches for Understanding Cancer Biology
Discussion Leaders: Luca Magnani (Imperial College London, United Kingdom) and John Hawse (Mayo Clinic, USA)
|
5:30 pm - 6:10 pm |
Timothy Willson (Structural Genomics Consortium, University of North Carolina at Chapel Hill, USA)
"Identification of Small Molecules to Shine Light on Dark Kinases"
|
6:10 pm - 6:20 pm |
Discussion
|
6:20 pm - 7:00 pm |
Gordon Hager (National Cancer Institute, NIH, USA)
"Chromatin Reprogramming in Breast Cancer"
|
7:00 pm - 7:10 pm |
Discussion
|
7:10 pm - 7:30 pm |
General Discussion
|
8:00 pm - 9:00 pm |
Dinner
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|