Mechanisms of Drug Resistance and Innovative Therapeutic Strategies

August 5 - 6, 2017

Chairs Jenny G. Parvani and Alicia M. Blessing

Grand Summit Hotel at Sunday River

97 Summit Road

Newry, ME, US

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Hormone-Dependent Cancers is a 2-day conference that is specifically geared towards supporting graduate students, postdocs, and other scientists with comparable levels of education. This meeting enables trainees the ability to share their research, freely ask questions and engage their peers, and meet leaders within their field.

The focus of this meeting is twofold: to understand the basic mechanisms of drug resistance across breast (all subtypes), prostate, ovarian, and other hormone-dependent cancers, and to highlight innovative therapeutic strategies that could offer additional and alternative therapeutic options for these diseases. In this unique forum, participants are able to a) present unpublished data in a friendly and safe environment that will foster scientific discussions and collaborations b) focus on career development via a keynote presentation and diverse career panel consisting of various leaders from academia, industry, and other areas and c) engage and network with senior scientists and mentors.

Related Meeting

This GRS will be held in conjunction with the "Hormone-Dependent Cancers" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Keynote Session: How to Maintain a Work/Life Balance as an Early Career Researcher Discussion Leader: Jenny Parvani (Case Western Reserve University, USA)
3:45 pm - 4:15 pm	Pepper Schedin (Oregon Health and Science University, USA) "One Scientist's Journey; Finding the Link Between Personal Happiness and Scientific Creativity"
4:15 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Estrogen and Progesterone Receptor Signaling in Hormone Dependent Cancers Discussion Leaders: Eric Bolf (University of Vermont, USA) and Matthew Sikora (University of Colorado Anschutz Medical Campus, USA)
7:30 pm - 7:50 pm	Nuria Padilla Just (University of Colorado Anschutz Medical Campus, USA) "Molecular Determinants of ER+ Breast Cancer Organ-Specific Metastasis"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Sankari Nagarajan (Cancer Research UK Cambridge Institute, United Kingdom) "Genome-Wide CRISPR Screening to Understand Drug Resistance in ER+ Breast Cancer"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Hari Singhal (Dana-Farber Cancer Institute, USA) "Genomic Analyses of Normal and Breast Cancer Tissue Identifies Grainy Head Like 2 (GRHL2) as a Key Tumor-Specific Oncogene"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	Soleilmane Omarjee (Cancer Research UK Cambridge Institute, United Kingdom) "Role of ERa-36 in Estrogen Non-Genomic Signaling and Breast Cancer"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	Lynsey Fettig (University of Colorado Anschutz Medical Campus, USA) "Progesterone Receptor-Retinoic Acid Receptor Crosstalk in Regulating a Breast Cancer Stem Cell Population"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Androgen Receptor and Other Signaling Mechanisms in Hormone Dependent Cancers Discussion Leaders: Lucas Brand (Thomas Jefferson University, USA) and Kristine Sikora (University of Colorado Denver, USA)
9:00 am - 9:20 am	Claire Nash (Research Institute of the McGill University Health Centre, Canada) "Genome-Wide Analysis of AR Binding and Transcriptomic Analysis of Primary Prostate Tumour Stroma and Prostate Mesenchyme"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	Iza Denis (Dame Roma Mitchell Cancer Research Laboratories, Australia) "AR Chromatin Binding Events Get Reprogrammed in the Absence of FOXA1 in ER-Breast Cancers"
9:45 am - 9:50 am	Discussion
9:50 am - 10:05 am	Chenchu Lin (University of Houston, USA) "CREB Is a Critical Factor in Androgen Receptor-Mediated Prostate Cancer Proliferation"
10:05 am - 10:10 am	Discussion
10:10 am - 10:30 am	Noelle Gillis (University of Vermont, USA) "Thyroid Hormone Receptor Beta (TR) Mediates Brama Related Gene 1 (BRG1, SMARCA4) Dependent Chromatin Remodeling for Tumor Suppression in Thyroid Cancer"
10:30 am - 10:40 am	Discussion
10:40 am - 10:55 am	Sakshi Gera (Indian Institute of Science, India) "Unraveling the Role of Follicle Stimulating Hormone and Notch Signaling in Ovarian Cancer"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Career Panel During this session, participants will be able to interact with a number of PhD-level career panelists. These panelists come from a variety of backgrounds, including academia, administration, industry, and scientific writing. Participants will be able to ask questions freely and engage in open discussions. Each panelist will offer a unique perspective and valuable advice for success for all of the early career scientists in attendance. Discussion Leader: Aarti Rohira (Baylor College of Medicine, USA)
1:30 pm - 2:30 pm	Panel Discussion Career Development Advice for Different Career Paths Kristine Sikora (University of Colorado Denver, USA) Matthew Sikora (University of Colorado Anschutz Medical Campus, USA) Luis Solorio (Purdue University, USA) Christopher Morrow (AstraZeneca, United Kingdom)
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes