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Hormone-Dependent Cancers

Gordon Research Conference

Big and Small Data in Hormone-Dependent Cancer: From Molecular Insights to Personalized Treatment

August 4 - 9, 2019

Chair

Vice Chair

Grand Summit Hotel at Sunday River

97 Summit Road

Newry, Maine, United States

Venue and Travel Information

Conference Description

The 2019 GRC on Hormone-Dependent Cancers will continue with a focus on bed-to-bedside science, including presentation on novel targets and pathways in breast, prostate, gynecological and other cancers. We will present historical perspectives on targeting hormone-dependent cancers, and importantly will include state-of-the-art approaches, such as the use of “Big Data”, and immune oncology studies. Early stage and experienced investigators, academic and industry representatives will present.

Related Meeting

This GRC will be held in conjunction with the "Hormone-Dependent Cancers" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Modeling of Hormone Action Discussion Leaders: and
7:40 pm - 8:05 pm	"The Evolution of Hormone-Dependent Cancer Research"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"From Dog Testicles to Super-Castration: A Historical Perspective of the Androgen Receptor"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	"Hormone-Dependent Breast Carcinogenesis: How Models Matter"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Advances in Targeting Steroid Receptors Discussion Leaders: and
9:00 am - 9:20 am	"Androgen Receptor and Non-Coding RNA: The Long and the Short of It"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Circular RNAs Add Diversity to Androgen Receptor Isoform Repertoire"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"ER and NFkB Regulated Breast Cancer Phenotypes"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"New Mechanistic and Therapeutic Insights into Aberrant Androgen Receptor Signaling in Prostate Cancer"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Mutants, Variants and Their Drugs"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Immuno-Oncology in Hormone-Dependent Cancers Discussion Leader:
7:30 pm - 7:50 pm	"Harnessing the Immune System for Breast Cancer Therapy"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Combination Therapies to Enhance Anti-Tumor Immunity in Luminal Breast Cancers"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"The Hostile Immune Microenvironment in Prostate Cancer"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"EMT Regulators in Immune Evasion of Breast Cancer"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Genetic Drivers of Heterogeneity and Progression in Hormone-Dependent Cancers Discussion Leaders: and
9:00 am - 9:20 am	"Molecular Heterogeneity in ER Positive Metastatic Breast Cancer"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"How Hormone Deprivation Influences Breast Cancer Immune Suppression"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Cracking the Code: Diving into the Non-Coding Genome of Hormone Dependent Cancers to Unravel Its Drivers"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"New Ways to Exploit Steroid Receptors for Breast Cancer Prevention and Treatment"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Clonal Evolution of the Androgen Receptor During Prostate Cancer Progression"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Functional and Clinical Insight into Gynecological Cancers and TNBC Discussion Leaders: and
7:30 pm - 7:50 pm	"Dissecting the Complexity of miRNAs in Ovarian Cancer Pathogenesis"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Epigenetic Approaches to CARM1-Expressing Ovarian Cancer"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Identifying and Targeting Vulnerabilities in Chemotherapy-Resistant Triple Negative Breast Cancer"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Understanding Endometrial Tumorigenesis: A New Frontier"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"BCL11A Induces Triple-Negative Breast Cancer Invasion and Metastasis by Suppressing MBNL1-Associated Alternative Splicing"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Novel Targets and Clinical Trials Discussion Leaders: and
9:00 am - 9:20 am	"Resistance to Combination Endocrine Therapy: Mechanisms and Therapeutic Implications"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Neoadjuvant Breast Cancer Therapy as a Platform to Evaluate Novel Agents"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Genomics of Metastatic and Resistant Thyroid Cancer: Defining New Therapeutic Targets"
10:50 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Targeting Prostate Cancer Drug Resistance"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Epigenetic Mechanisms of Glucocorticoid Receptor Signaling in Cancer"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Racial Differences in Prostate Cancer"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Early-Career Investigator Presentations Discussion Leaders: and
7:30 pm - 7:45 pm	"Genome-Wide CRISPR Screening Identifies SWI/SNF Chromatin Remodeling Complex in Endocrine Drug Resistance"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"Novel Molecular Determinants of Metastatic Breast Cancer"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Impact of Obesity and Weight Gain on Postmenopausal Breast Cancers: Insight from Preclinical Models"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Hormone Receptor Cross-Talk in Breast Cancer"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Thyroid Hormone Mediated Tumor Suppression in Anaplastic Thyroid Cancer"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"TGFβ Crosstalk with Androgen Receptors in Triple-Negative Breast Cancer"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Loss of Ovarian Estradiol and Increased Estrone in Obesity Promote Postmenopausal Mammary Inflammation and ER+ Breast Cancer Progression"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Computational Approaches and Big Data Discussion Leaders: and
9:00 am - 9:20 am	"Hormone-Dependent Cancers Evolution from Unbiased Allele Specific Analyses"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Uncovering Vulnerabilities in Advanced Lobular Carcinomas Through Genomic Profiling"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Drivers of Breast Cancer Metastases"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Exploring the Breast and Prostate Microenvironment Using Multi-Dimensional Single Cell Genomics"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Unique Breast Cancer Subtypes"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Novel Redox-Regulated Mechanisms Underlying Castration-Resistant Prostate Cancer Progression"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Comprehensive Transcriptomic Profiling Identifies Breast Cancer Patients Who May Be Spared Adjuvant Systemic Therapy"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Keynote Session: New Perspectives in Therapeutic Targeting of Hormone-Dependent Cancers Discussion Leaders: and
5:30 pm - 5:55 pm	"Next Generation ER Therapeutics for Breast Cancer: Same Strategy, Different Beasts"
5:55 pm - 6:05 pm	Discussion
6:05 pm - 6:30 pm	"Endocrine Therapy: Revisiting the Past to Discover the Future"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 7:05 pm	"Fickle, Thy Name Is Androgen Receptor"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:30 pm	General Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by 1R13CA239572-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Hormone-Dependent Cancers (GRS)

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