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Hormone-Dependent Cancers (GRS)

Gordon Research Seminar

Overcoming Endocrine Resistance and Metastasis in Hormone-Dependent Cancers

August 3 - 4, 2019
Chairs Hillary Stires and Sankari Nagarajan
Grand Summit Hotel at Sunday River
97 Summit Road
Newry, Maine, United States
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Hormone-Dependent Cancers is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. The meeting provides trainees with opportunities to network and collaborate with others performing similar research as well as to meet leaders in the field through career development focused presentations.

While the last 50 years have provided major advancements for the treatment and eradication of hormone-dependent cancers, these options have disadvantages for many patients including ineffectiveness, intolerable side effects, and endocrine resistance. This meeting will focus on both (1) factors that drive endocrine resistance and metastasis and (2) alternative therapies for hormone-dependent cancers including breast, prostate, ovarian, and others.

Related Meeting

This GRS will be held in conjunction with the "Hormone-Dependent Cancers" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Career Development for Early Career Researchers
Dr. Karen Knudsen, director of the Sidney Kimmel Cancer Center - Jefferson Health and vice president/president-elect of the board of directors for Association of American Cancer Institutes will give a keynote presentation with advice for trainees and an overview of her experiences in becoming a leader in hormone-dependent cancers.
Discussion Leader: Catherine Sevigny (Georgetown University, USA)
3:45 pm - 4:20 pm
Karen Knudsen (Sidney Kimmel Cancer Center, Jefferson Health, USA)
"Career Development for Early Career Researchers"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hormones that Drive Cancer Development and Metastasis
Discussion Leader: Stacey Joosten (Netherlands Cancer Institute, The Netherlands)
7:30 pm - 7:45 pm
Zannel Blanchard (University of Utah, USA)
"Estrogen-Independent Activity of Mutant Estrogen Receptor Alpha in Endometrial Cancer"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Eric Bolf (University of Vermont, USA)
"Thyroid Hormone Mediated Tumor Suppression in Anaplastic Thyroid Cancer"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jamie Kutasovic (The University of Queensland, Australia)
"Alternative Oestrogen Regulated Transcription Driving Metastatic Colonisation of Gynaecological Organs"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Isabel Mayayo Peralta (Netherlands Cancer Institute, The Netherlands)
"Characterizing the Interplay Between Steroid Hormone Receptors in Breast Cancer"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Sayali Onkar (University of Pittsburgh School of Medicine, USA)
"Investigating the Immune Microenvironment of Primary Invasive Lobular Breast Carcinoma"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jessica Pilsworth (BC Cancer, Canada)
"Genomic Characterization of Adult Type Granulosa Cell Tumours Reveals Mutations in Epigenetic Regulators"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Overcoming Drug Resistance in Hormone-Dependent Cancers
Discussion Leader: Justin Hwang (Dana Farber Cancer Institute, USA)
9:00 am - 9:15 am
Mark Daniel (University of Minnesota, USA)
"Wnt Enhanceosome Component TLE3 Functions as an AR Co-Regulator and Supports Anchorage-Independent Growth in AR Variant-Driven Prostate Cancer Models"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Rajdeep Das (University of California, San Francisco, USA)
"Investigating Kinesin Family Member 4A as a Novel Driver of Aggressive Prostate Cancer"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Simon Linder (Netherlands Cancer Institute, The Netherlands)
"Integrative Cistromic Profiling of High-Risk Prostate Cancer Before and After Neoadjuvant Enzalutamide Treatment"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Emmanuel Rosas (University of Colorado Anschutz Medical Campus, USA)
"TGFβ Crosstalk with Androgen Receptors in Triple-Negative Breast Cancer"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Nicole Traphagen (Dartmouth College, USA)
"Estrogen Therapy for Advanced Breast Cancer: Understanding the Mechanism of Action Leads to Strategies to Improve Response and Reduce Toxicity"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Thu Truong (University of Minnesota, USA)
"Steroid Receptor Co-Activators Reprogram Metabolic Pathways that Drive Luminal Breast Cancer Stemness"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Exploring Career Opportunities for Cancer Biologists
During this session, participants will be able to interact with a number of PhD-level career panelists. These panelists come from a variety of backgrounds, including academia, industry, and policy. Participants will be able to ask questions freely and engage in open discussions. Each panelist will offer a unique perspective and valuable advice for success for all of the early career scientists in attendance.
Discussion Leader: Evelyn Bordeaux (University of Colorado Anschutz Medical Campus, USA)
1:30 pm - 2:30 pm
Panel Discussion
Career Opportunities for Cancer Biologists
  • Courtney Andersen (AstraZeneca, USA)
  • Charlotte Bevan (Imperial College London, United Kingdom)
  • Jamie Holloway (Caris Life Sciences, USA)
  • Daniel Gioeli (University of Virginia, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes

Contributors

National Institutes of Health - National Cancer Institute
Georgetown University - Lombardi Comprehensive Cancer Center

University of Colorado Cancer Center

Funding for this conference was made possible (in part) by 1R13CA239572-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Hormone-Dependent Cancers
Additional Fee Info

Hormone-Dependent Cancers
August 10 - 15, 2025


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