Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Interpreting Human Genetic Variation
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"At The Forefront of Genomics: Making Genomic Medicine a Reality"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mapping the Regulatory Wiring of the Genome to Link Disease Variants to Functions"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Small Nuclear RNAs in Rare Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Effects of DNA Variants
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Functional Variation in the Human Genome: Insights from Population Genomics and CRISPR Perturbations"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Building an Atlas of Variant Effects for the Human Genome"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Functional Characterization and Therapeutic Targeting of Gene Regulatory Elements"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Statistical Methods and Large Datasets for Complex Trait Genetics
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Machine Learning in Personal Genomics and Disease Risk Prediction"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Biobanks and the Road Ahead in Human Genetics"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"An Epidemiological Approach to Modeling Complexity in Genetic Risk for Diverse Groups"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Imprint of Evolution on Human Genetic Diversity
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Why Does Genomic Trait Prediction Translate Poorly Across Human Ancestries?"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Between-Population Genetic and Phenotypic Differences in Complex Traits"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Genomic Insights into Human Population History & Disease"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biological Mechanisms of Variant Function
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Mechanisms and Logic of Hirschsprung Aganglionosis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Using Stem Cells to Explore the Genetics Underlying Brain Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Revisiting Mendelian Disease Phenotypes: Insights from Electronic Health Records"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics in Development of Therapeutics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Humanizing Drug Discovery"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"The Genetics of Obesity: From Genes to Biology and Precision Medicine"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Explaining and Acting on a Large Number of GWAS Loci of Immune-Related Diseases by a Shared Mechanism"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Regulation in Time and Space
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"New Frontiers in Pooled Genetics Screens"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Single-Cell Epigenomics and the Regulatory Control of Cells"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Late-Breaking Topic
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Role of Technology and Computation in Human Genetics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Complete Genomes to Pangenomes: Expanding Our Understanding of Human Haplotype Variation"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Evolution-Informed Language Models of Biological Sequences"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Modeling the Impact of Personal Genome Variation on Molecular Phenotypes"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Quantitating Disease Likelihood in Population and Opportunistic Genomic Screening"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Getting the Genome to the Clinic"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Understanding Intellectual Disability"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure