| Sunday, 30 May |
| 2 - 9 pm |
Registration |
| 6:00 pm |
Dinner |
| 7:30 pm |
Welcome Remarks |
| MHC biosynthesis and antigen presentation |
| Sunday, PM |
Peter Cresswell, discussion leader |
| 7:40 - 8:00 |
Peter Cresswell (Yale School of Medicine)
Regulation of the Assembly of MHC-Peptide Complexes |
| 8:00 - 8:10 |
Discussion |
| 8:10 - 8:30 |
Andrew McMichael (Oxford University)
Functions of HLA class I molecules |
| 8:30 - 8:40 |
Discussion |
| 8:40 - 9:00 |
Lars Karlsson (R.W. Johnson Pharmaceutical Research Institute)
Non-classical class II molecules in antigen presentation |
| 9:00 - 9:10 |
Discussion |
| 9:10 - 9:30 |
Michael Brenner (Harvard Medical School)
Role of CD1 in antigen presentation |
| 9:30 - 9:40 |
Discussion |
| 9:40 |
Welcome Reception (Italian Wine and Cheese) |
| Monday, 31 May |
| 7:30 am |
Breakfast |
| Mechanisms regulating lymphocyte receptor diversity |
| Monday, AM |
David Schatz, discussion leader |
| 9:00 - 9:25 |
David Schatz (Yale School of Medicine)
Mechanistic studies of V(D)J recombination |
| 9:25 - 9:35 |
Discussion |
| 9:35 - 10:00 |
Yehudit Bergmann (Hebrew University)
Differential kappa gene accessibility and the establishment of allelic exclusion |
| 10:00 - 10:10 |
Discussion |
| 10:10 - 10:50 |
Coffee Break & Group Photo |
| 10:50 - 11:15 |
Jean Claude Weill (Institut Necker)
Mechanism of Ig gene hypermutation |
| 11:15 - 11:25 |
Discussion |
| 11:25 - 11:50 |
Martin Weigert (Princeton University)
Somatic mutation and V gene replacement in autoimmunity
|
| 11:50 - 12:00 |
Discussion |
| 12:30 |
Lunch |
| 4:30 |
Coffee and Cookies |
| Signals in lymphocyte development |
| Monday, PM |
Ellen Robey, discussion leader |
| 5:00 - 5:20 |
Ellen Robey (UC, Berkeley)
Regulation of T cell fate by Notch |
| 5:20 - 5:30 |
Discussion |
| 5:30 - 5:50 |
Ed Palmer (Basel Institute for Immunology)
How does the TCR mediate both positive and negative selection? |
| 5:50 - 6:00 |
Discussion |
| 6:00 - 6:10 |
Klaus Eichmann (Freiburg)
Control of TCR-beta locus expression by CD3-associated signaling |
| 6:10 - 6:15 |
Discussion |
| 6:15 - 6:45 |
Coffee Break |
| 6:45 - 7:05 |
Rose Zamoyska (Mill Hill)
Do distinct signals discriminate CD4 versus CD8 lineage commitment in the thymus? |
| 7:05 - 7:15 |
Discussion |
| 7:15 - 7:35 |
Richard Flavell (Yale School of Medicine)
The role of lymphotoxin in lymphocyte biology |
| 7:35 - 7:45 |
Discussion |
| 7:45 - 7:55 |
Harumi Suzuki (Keio University, Tokyo)
Xid-like immunodefiency in mice with disruption of the p85alpha subunit of PI-3 kinase |
| 7:55 - 8:00 |
Discussion |
| 8:30 |
Dinner |
| 10:00 |
Poster Session I |
| Tuesday, 1 June |
| 7:30 |
Breakfast |
| Tracking immune responses in vivo |
| Tuesday, AM |
John Kappler, discussion leader |
| 9:00 - 9:30 |
John Kappler (National Jewish Center)
Tracking CD4+ T cells in Normal and Autoimmune Responses |
| 9:30 - 9:40 |
Discussion |
| 9:40 - 10:10 |
Beneditta Rocha (Institute Necker)
CD8 T cell memory |
| 10:10 - 10:20 |
Discussion |
| 10:20 - 10:50 |
Coffee Break |
| 10:50 - 11:10 |
Peter Savage (Stanford University)
Monitoring Specific Populations of T cells in Cancer Patients |
| 11:20 - 9:40 |
Discussion |
| 11:40 - 12:10 |
Marc Jenkins (Univ. of Minnesota)
Analysis of the activation of antigen-specific lymphocytes in situ |
| 12:10 - 12:20 |
Discussion |
| 12:30 |
Lunch |
| 4:30 |
Coffee and Cookies |
| Lymphocyte decisions in the periphery |
| Tuesday, PM |
Craig Thompson, discussion leader |
| 5:00 - 5:30 |
Craig Thompson (Univ. of Chicago)
Why is naive lymphocyte survival dependent on self-peptides? |
| 5:30 - 5:35 |
Discussion |
| 5:35 - 6:05 |
Paul Allen (Washington Univ. School of Medicine)
Kinetics and Fidelity of T cell Activation |
| 6:05 - 6:10 |
Discussion |
| 6:10 - 6:40 |
Coffee Break |
| 6:40 - 7:10 |
Juan Lafaille (Skirball Institute, New York University Medical Center)
Suppression of autoimmune encephalomyelitis by regulatory lymphocytes |
| 7:10 - 7:15 |
Discussion |
| 7:15 - 7:35 |
Cox Terhorst (BI/Deaconess)
XLP and SAP |
| 7:35 - 7:40 |
Discussion |
| 7:40 - 8:00 |
Philippa Marrack (National Jewish Center)
Use of microarrays to identify genes involved in T cell survival versus death |
| 8:00 - 8:05 |
Discussion |
| 8:30 |
Dinner |
| 10:00 |
Poster Session II |
| Wednesday, 2 June |
| 7:30 |
Breakfast |
| Mechanisms of innate immune regulation |
| Wednesday, AM |
Charlie Janeway, discussion leader |
| 9:00 - 9:30 |
Charlie Janeway (Yale School of Medicine)
Conserved host defense systems from tomatoes to man |
| 9:30 - 9:40 |
Discussion |
| 9:40 - 10:10 |
Bruce Beutler (UT Southwestern Medical Center)
Positional cloning of Lps, central component of the sole pathway for detection of bacterial endotoxin |
| 10:10 - 10:20 |
Discussion |
| 10:20 - 10:50 |
Coffee Break |
| 10:50 - 11:20 |
Antonio Lanzavecchia (Basel Institute)
Dendritic cell maturation and activation |
| 11:20 - 11:30 |
Discussion |
| 11:30 - 12:00 |
David Raulet (UC, Berkeley)
Acquisition and function of MHC-specific receptors expressed by NK cells |
| 12:00 - 12:10 |
Discussion |
| 12:30 |
Lunch |
| 4:30 |
Coffee and Cookies |
| Genomics and the immune system |
| Wednesday, PM |
Richard Myers, discussion leader |
| 5:00 - 5:15 |
Richard Myers (Stanford University)
Introduction: Overview of genome research and resources, 1999 - 2003 |
| 5:15 - 5:40 |
Louis Staudt (NIH)
Genomic views of gene expression in normal and malignant lymphocytes using the Lymphochip cDNA microarray |
| 5:40 - 5:50 |
Discussion |
| 5:50 - 6:15 |
Chris Goodnow (Australian National University)
Forward genetics and the mouse immune system |
| 6:15 - 6:25 |
Discussion |
| 6:25 - 6:55 |
Coffee Break |
| 6:55 - 7:20 |
Marc Vidal (Harvard Medical School/MGH Cancer Center)
The C. elegans protein interaction mapping project: high-throughput identification and validation of protein-protein interactions |
| 7:20 - 7:30 |
Discussion |
| 7:30 - 7:55 |
Richard Myers (Stanford University)
Understanding the role of genetic variation in common human diseases - Promises and pitfalls of a pharmacogenetics approach |
| 7;55 - 8:05 |
Discussion |
| 8:05 - 8:20 |
Business Meeting |
| 8:30 |
Dinner |
| Thursday, 3 June |
| 7:30 |
Breakfast |
| Lymphoid organogenesis |
| Thursday, AM |
George Kollias, discussion leader |
| 9:00 - 9:30 |
George Kollias (Hellenic Pasteur Institute, Athens)
TNF and the p55TNF-R are required for the development of the splenic marginal zone and for the migration of FDC precursors into the follicles |
| 9:30 - 9:35 |
Discussion |
| 9:35 - 10:05 |
Eric Pringault (Institut Pasteur)
M cell differentiation and function in the gut |
| 10:05 - 10:10 |
Discussion |
| 10:10 - 10:40 |
Coffee Break |
| 10:40 - 11:10 |
Klaus Pfeffer (Univ of Munich)
Ontogeny of peripheral lymphoid organs and germinal center formation as controlled by lymphotoxins, TNF and their receptors |
| 11:10 - 11:15 |
Discussion |
| 11:15 - 11:45 |
Jason Cyster (UCSF)
Chemokines and B lymphocyte homing |
| 11:45 - 11:50 |
Discussion |
| 12:30 |
Lunch |
| 4:30 |
Coffee and Cookies |
| Strategies for enhancing immunity |
| Thursday, PM |
Jim Allison, discussion leader |
| 5:00 - 5:30 |
Kees Melief (Leiden Univ)
DC regulation of CTL responses |
| 5:30 - 5:35 |
Discussion |
| 5:35 - 6:05 |
Jim Allison (UC, Berkeley) - Inhibitory Signals in T cell Activation and their Manipulation in Tumor Immunotherapy |
| 6:05 - 6:10 |
Discussion |
| 6:10 - 6:40 |
Coffee Break |
| 6;40 - 7:10 |
Norman Letvin (BI/Deaconess Medical Center, Harvard Medical School)
T cell immunity in lentiviral pathogenesis |
| 7:10 - 7:15 |
Discussion |
| 7:15 - 7:45 |
Rafi Ahmed (Emory Univ. School of Med)
Memory T Cells: Functional Characteristics and Maintenance Requirements |
| 7:45 - 7:55 |
Discussion |
| 8:30 |
Gala Dinner |
| Friday, 4 June |
| 7:30 |
Breakfast |
