Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | New Insights into Intermediate Filaments as Integral Regulators in Health
and Disease |
| Discussion Leaders: Karen Ridge (Northwestern University, USA) and Iris Lähdeniemi (Åbo Akademi University, Finland) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:10 pm | Yosef Gruenbaum (Hebrew University of Jerusalem, Israel) "The Crosstalk Between Lamin, Aging and Metabolism" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Robert Goldman (Northwestern University, USA) "Intermediate Filaments Play a Pivotal Role in
Regulating Cell Architecture and Function" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Bishr Omary (University of Michigan, USA) "Intermediate Filaments: The Path Forward" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Causes and Consequences in Neurodegeneration
and CNS Repair |
| Discussion Leaders: Harish Pant (National Institute of Neurological Disorders and Stroke, NIH, USA) and Mala Rao (Nathan Kline Institute for Psychiatric Research, USA) |
9:00 am - 9:20 am | Milos Pekny (University of Gothenburg, Sweden) "Astrocyte Intermediate Filament Proteins and CNS Regeneration" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Thomas Shea (University of Massachusetts, USA) "Novel Aspects of Phosphorylation
in Regulation of Neurofilament Function" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:25 am | Coffee Break |
10:25 am - 10:40 am | Jin-Moo Lee (Washington University School of Medicine, USA) "Intermediate Filaments in Alzheimer's Disease Astrocyte-Plaque Interactions" |
10:40 am - 10:50 am | Discussion |
10:50 am - 11:05 am | Elly Hol (Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands) "GFAP and Vimentin Deficiency Alters Gene Expression in Astrocytes" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Ben Szaro (University at Albany, State University of New York, USA) "Specific Introns Mediate Post-Transcriptional Control of Neurofilament Reporter Gene Expression In Vivo" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Albee Messing (University of Wisconsin-Madison, USA) "New Approaches to the Study of GFAP and
Alexander Disease" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Ronald Liem (Columbia University, USA) "Mechanisms that Cause Neurofilaments to Accumulate During Development and Disease" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Intersection of Cell Stress and Disease |
| Discussion Leaders: Birgit Lane (Institute of Medical Biology, A*STAR, Singapore) and Lori Wallrath (University of Iowa, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 7:55 pm | Dolores Perez-Sala (Spanish National Research Council (CSIC), Spain) "Oxidative Stress and Interaction with Zinc Expose
Hidden Features of Intermediate Filaments" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:15 pm | Pekka Taimen (University of Turku, Finland) "Deleterious Assembly of Mutant pS143P Lamin A/C Causes ER Stress in Familial Dilated Cardiomyopathy" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Pedro Salas (University of Miami, USA) "Epithelial Control of Innate Immunity Downstream of
Krt8: Can We Get to Mechanistic Approaches?" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Vladimir Gelfand (Feinberg School of Medicine, Northwestern University, USA) "Vimentin Filament Precursors Exchange Subunits
in an ATP-Dependent Manner" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Ryan Hobbs (Johns Hopkins University Bloomberg School of Public Health, USA) "Forms and Functions of Keratins in the Nucleus" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cellular Organization,
Adhesion, and Migration |
| Discussion Leaders: Jan Lammerding (Cornell University, USA) and Justin Chung (The Catholic University of America, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:25 am | Kathleen Green (Northwestern University, USA) "Desmosome Regulation and Signaling in Disease" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Iris Lähdeniemi (Åbo Akademi University, Finland) "Keratins Modulate the Hypoxic Response in Colonic Epithelial Cells" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Rudolf Leube (RWTH Aachen University, Germany) "Regulation of Intermediate Filament Network Organization in Epithelial Cells" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Franziska Lautenschlager (Saarland University, Germany) "Vimentin in Ameoboid Migration" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Cecilia Sahlgren (Eindhoven University of Technology, The Netherlands / Åbo Akademi University, Finland) "Intermediate Filaments as Determinants of Notch
Receptor Routing and Activity" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Stephanie Portet (University of Manitoba, Canada) "Transport of Intermediate Filaments in Cells: Mathematical Modeling Approach" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Janice Walker (Thomas Jefferson University, USA) "Cells Activated for Wound Repair Have the Potential to Direct Collective Invasion of an Epithelium" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cardiac and Muscular Control
and Diseases |
| Discussion Leaders: Pekka Taimen (University of Turku, Finland) and Ryan Hobbs (Johns Hopkins University Bloomberg School of Public Health, USA) |
7:30 pm - 7:45 pm | Gisele Bonne (Université Pierre-et-Marie-Curie / Inserm, France) "New Insights in the Pathophysiology of Striated Muscle Laminopathies" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Howard Worman (Columbia University, USA) "Lamins and Associated Proteins in
Striated Muscle Disease" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Giulio Agnetti (Johns Hopkins University, USA) "Post-Translationally Modified Desmin:Aa Likely Seed for the Alzheimer's
of the Heart?" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Lori Wallrath (University of Iowa, USA) "Lamin-Associated Muscular Dystrophy: Myofibers Under Reductive Stress" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Yassemi Capetanaki (Biomedical Research Foundation, Academy of Athens, Greece) "Importance of Intermediate Filaments in Mitochondrial
Homeostasis and Cardioprotection" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulating the Cell Microenvironment and Mechanotransduction |
| Discussion Leaders: Paul Janmey (University of Pennsylvania, USA) and Qi Wen (Worcester Polytechnic Institute, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Gaudenz Danuser (University of Texas Southwestern Medical Center, USA) "Organization of Actin and Microtubule Dynamics by Vimentin" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Gerhard Wiche (Max F. Perutz Laboratories, University of Vienna, Austria) "Keeping Up the Tension with Plectin and Intermediate Filaments" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:50 am | Frederik Fleissner (Max Planck Institute for Polymer Research, Germany) "Microspectroscopy of Intermediate Filament Secondary Structure Under Load" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:15 am | Dennis Discher (University of Pennsylvania, USA) "Invasion-Mutation: Constricted Cell Migration Causes Nuclear Lamina Damage, DNA Breaks, Repair Factor Squeeze-Out, and Genomic Variation" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Noam Zuela (Hebrew University of Jerusalem, Israel) "Mechanical Model for Human Laminopathies Using the L535P EDMD Lamin Mutation" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Liqun Wang (Brigham and Women's Hospital, Harvard Medical School, USA) "Mechanical Alterations Induce Toxicity in Alexander Disease via Lamin and YAP" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Roy Beck-Barkai (Tel-Aviv University, Israel) "Order and Disorder in Intermediate Filament Proteins" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Aging and Premature Aging Diseases |
| Discussion Leaders: Yosef Gruenbaum (Hebrew University of Jerusalem, Israel) and Stephen Adam (Northwestern University, USA) |
7:30 pm - 7:50 pm | Roland Foisner (Medical University of Vienna, Austria) "The Role of Nucleoplasmic Lamins and LAP2α in Progeria Premature Aging Disease" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:15 pm | Quasar Padiath (University of Pittsburgh, USA) "Elucidating Mechanisms of Lamin B1 Mediated Demyelination in Autosomal Dominant Leukodystrophy (ADLD)" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Joseph Tran (Carnegie Institution for Science, USA) "Lamin-B and Age-Associated De-Repression of Retrotransponsons" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Agustin Sola Carvajal (Karolinska Institute, Sweden) "Analyzing the Symmetry of Adult Stem Cell Division in Hutchinson-Gilford Progeria Syndrome" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Ohad Medalia (University of Zurich, Switzerland) "The Structural Analysis of Lamins in Somatic Cells" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Complexity, Integrations,
and Regulation of Signaling Networks |
| Discussion Leaders: Roy Quinlan (Durham University, United Kingdom) and Milind Vaidya (Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), India) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Pierre Coulombe (Johns Hopkins Bloomberg School of Public Health, USA) "Interplay Between Keratin and Redox Balance in Skin Keratinocytes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Boopathi Ettickan (Thomas Jefferson University, USA) "Mammalian Target of Rapamycin (mTOR) Regulates Mechanical Stretch Induced Expression of Vimentin in Bladder Smooth Muscle in Aging Male Population" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:35 am | Coffee Break |
10:35 am - 10:50 am | Natasha Snider (University of North Carolina at Chapel Hill, USA) "Direct and Indirect Approaches for Pharmacological Targeting of Intermediate Filaments" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:15 am | Daniel Kaganovich (Hebrew University of Jerusalem, Israel) "Imperfect Asymmetry: The Mechanism Governing Asymmetric Partitioning of Damaged Cellular Components During Mitosis" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Pavel Strnad (University Hospital Aachen, Germany) "Keratins - Markers and Modulators of Hepatobiliary System" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | John Eriksson (Abo Akademi University, Finland) "IFs as Determinants of Cell Fate" |
12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Metabolic Regulation and Mitochondria |
| Discussion Leaders: Normand Marceau (Laval University, Canada) and Monique Cadrin (Université du Québec à Trois-Rivières, Canada) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Thomas Magin (Leipzig University, Germany) "Scaffolding the Powerhouse – Implications of a Keratin-Mitochondrial Connection" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Alexander Minin (Russian Academy of Sciences, Russia) "Mitochondrial Membrane Potential Is Regulated by Vimentin Intermediate Filaments" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:50 pm | Kan Cao (University of Maryland, USA) "Methylene Blue Alleviates Nuclear and Mitochondrial Abnormalities in Progeria" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Diana Toivola (Abo Akademi University, Finland) "Keratins in β-Cells and Insulin Secretion" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |