Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Biophysical Approaches to Elucidate the Central Role of Intermediate Filaments in Cellular Mechanobiology
Discussion Leader: Tom Golde (Institut de Bioenginyeria de Catalunya, Spain)
3:15 pm - 3:45 pm
Gijsje Koenderink (Delft University of Technology, The Netherlands)
"How Cytoskeletal Crosstalk Mediated via Intermediate Filaments Makes Cells Strong"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Insights into the Molecular Structure and Assembly of Intermediate Filament Networks
Discussion Leader: Tanmay Sadhanasatish (University of Muenster, Germany)
5:30 pm - 5:40 pm
Tom Golde (Institut de Bioenginyeria de Catalunya, Spain)
"Keratin Bundle Transition as a Stress Adaptation Mechanism"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Emilia Holm (Åbo Akademi University, Finland)
"Vimentin Filament Assembly Found to be Regulated by a Continuous Spatiotemporal Phosphorylation Pattern Involving Several Conserved Phosphorylation Motifs of the N-terminal"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Suyash Naik (Institute for Science and Technology, Austria)
"Mechanosensitive Crosstalk Between Keratin IFs and Contractility Mediates Zebrafish Epithelial Morphogenesis"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Jacob Odell (Cornell University, United States)
"Investigating Lamin Biology Through Chimeras and Truncations"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Lilian Paty (CNRS UMR7592, Institut Jacques Monod , France)
"Vimentin Promotes Actin Assembly at the Barbed End"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Cassandra Phillips (University of North Carolina at Chapel Hill, United States)
"New molecular insights into Giant Axonal Neuropathy (GAN) from Gigaxonin Interactome Studies"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Lovis Schween (Friedrich-Alexander-Universität, Erlangen-Nürnberg, Germany)
"Desmin Filament Assembly Characteristics and the Loss of Elongation Control in Mutant R406W"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Lani Lee (Massachusetts Institute of Technology, United States)
"Aging Changes in Cell Mechanics and Dynamics Observes a Backbone of Cytoplasmic Crowding"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
The Role of Intermediate Filaments in Integrating Biochemical and Biophysical Cues and Disease Development
Discussion Leader: Giulia Sultana (Abo Akademi University, Finland)
9:00 am - 9:10 am
Nilüfer Düz (Hacttepe University, Turkey)
"Beyond the Cytoplasm: Exploring Desmin's Nuclear Dynamics and Regulatory Functions in Muscle Physiology"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Sarah Steiner (University of Michigan, United States)
"KRT9/K9 Regulates Mechanosensitive Signaling and Epidermal Homeostasis in Palmoplantar Skin"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Sarah Peeters (University of Antwerp, Belgium)
"Excessive Nuclear Envelope Stress Blunts Invasive Potential of Glioblastoma Cells."
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Renita Saldanha (Syracuse University, United States)
"Exploring Vimentin's Effects on Centrosome Functioning and Microtubule Dynamics"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Julia Kraxner (Max Delbrück Center Berlin, Germany)
"From Single Cytoskeleton Molecule to Endothelial Cell Mechanics"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Romy Timmer (Institute of Basic Medical Sciences, University of Oslo, Norway)
"LRRC59 as a Novel Regulator of the ESCRT-LEM Compartmentalization Sensor in Nuclear Envelope Integrity and Cancer Progression"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Xiuyu WANG (Universte de Paris, France)
"Lamins Regulate Nuclear Mechanics and Shape to Control Glioblastoma’s Aggressiveness"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Bronson Frank (The Ohio State University, United States)
"Measuring Mechanical Forces Across the Vimentin Network with a FRET Force Biosensor"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Different Scientific Career Paths and Managing Transitions
Discussion Leader: Maxx Swoger (Syracuse University, United States)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Different Scientific Career Paths and Managing Transitions
Emma van Bodegraven (University Medical Center, Utrecht Brain Center, The Netherlands)
Tyler Kirby (Amsterdam University Medical Center, The Netherlands)
Kyle Wilcox (AbbVie, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes