| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MOLECULAR BASIS FOR REGULATION |
| 7:30 pm - 7:40 pm | Discussion Leader: John Adelman (Oregon Health & Science University) |
| 7:40 pm - 8:05 pm | Robert Reenan (University of Connecticut)
"Evolutionary Diversification of Ion Channels by RNA Editing-Why?" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Ming Zhou (Columbia University)
"Modulation of Shaker family K channels by an oxidoreductase" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Breaking News: Leigh Plant (University of Chicago)
"Sumoylation controls the excitability of hippocampal neurons" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Breaking News: Yasushi Okamura (Okazaki Institute for Integrative Bioscience)
"Mechanisms of voltage sensor domain proteins" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | LIGAND-GATED CHANNELS |
| 9:00 am - 9:10 am | Discussion Leader: Henry Lester (California Institute of Technology) |
| 9:10 am - 9:35 am | Mark Mayer (National Institutes of Health)
"Gating of AMPA and kainate subtype iGluRs: New structures and mechanisms" |
| 9:35 am - 9:45 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:55 am | Vasanthi Jayaraman (University of Texas Health Center)
"AMPA receptors as seen with light" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Robert Oswald (Cornell University)
"AMPA receptor dynamics" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Yun Zhang (Rockefeller University)
"A serotonin-gated chloride channel that regulates olfactory learning in C. elegans" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | VIRUSES, BACTERIA, & FLIES, OH, MY! |
| 7:30 pm - 7:40 pm | Discussion Leader: Professor Milli Osmol (Ellesmere Island, Canada) |
| 7:40 pm - 8:05 pm | Alan Finkelstein (Albert Einstein College of Medicine)
"Protein Translocation through the Anthrax Toxin Channel" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | William DeGrado (University of Pennsylvania)
"Analysis and Design of Membrane Proteins" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Breaking News: Anna Moroni (University of Milano)
"Gating properties of the viral K+ channel Kcv" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Breaking News: Steve Long (Rockefeller University)
"Crystal structure of Kv1.2, a Shaker family voltage-gated potassium channel" |
| 9:20 pm - 9:25 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHLORIDE & PROTON TRANSPORT |
| 9:00 am - 9:10 am | Discussion Leader: Alessio Accardi (Brandeis University) |
| 9:10 am - 9:35 am | Raimund Dutzler (University of Zurich)
"The regulatory domains of ClC channels and transporters" |
| 9:35 am - 9:45 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:55 am | Michael Pusch (National Research Council)
"Chloride / proton antiport of mammalian CLC proteins" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:20 am | Breaking News: Ian Scott Ramsey (Harvard University)
"The voltage sensor domain protein HVCN1 encodes a voltage-gated proton channel" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:40 am | Breaking News: Jie Zheng (University of California at Davis School of Medicine)
"Large Movement of the C-terminus of CLC-0 Chloride Channel during Slow Gating" |
| 11:40 am - 11:45 am | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PERMEATION |
| 7:30 pm - 7:40 pm | Discussion Leader: Wolfgang Nonner (University of Miami, Miller School of Medicine) |
| 7:40 pm - 8:05 pm | Claudio Grosman (University of Illinois, Urbana-Champaign)
"Probing the structure and electrostatics of ion-channel pores one proton at a time" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Karl Magelsby (University of Miami, Miller School of Medicine)
"Conductance and Block of BK Channels: Contribution of the Ring of Negative Charge at the Entrance to the Inner Cavity" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Breaking News: Sergei Y. Noskov (University of Chicago)
"A physical view of Na+/K+ selectivity in flexible and rigid protein binding sites" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Breaking News: Christopher Ahern (Thomas Jefferson University)
"Once Again, Function Trumps Structure: TEA Block of Shaker" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GATING I |
| 9:00 am - 9:10 am | Discussion Leader: Gary Yellen (Harvard University) |
| 9:10 am - 9:35 am | Roderick MacKinnon (Rockefeller University)
"X-ray structure and function of voltage-gated K+ channels" |
| 9:35 am - 9:45 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:55 am | Eduardo Perozo (University of Chicago)
"Selectivity filter Dynamics and the Gating Mechanisms of KcsA" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Benoit Roux (University of Chicago)
"Potassium channels: Ion Conduction, selectivity, gating and inactivation" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Mark Sansom (University of Oxford)
"Atomistic and Coarse-Grained Simulations of Ion Channels: Insights into Channel/Lipid Interactions and Gating" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHEMICAL BIOLOGY / LIPID-PROTEIN INTERACTIONS |
| 7:30 pm - 7:40 pm | Discussion Leader: Olaf Sparre Andersen (Cornell University) |
| 7:40 pm - 8:05 pm | Gunnar von Heijne (Royal Swedish Academy of Sciences)
"How membrane proteins make it into the ER" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Scott Feller (Wabash College)
"Unique properties of polyunsaturated lipids and their interactions with membrane proteins" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Breaking News: Min Li (Johns Hopkins University)
"Chemical activation of KCNQ potassium channels" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Breaking News: Michael D. Grabe (University of California, San Francisco; HHMI)
"Insight into the down state of the voltage-sensor from computations combined with yeast screens" |
| 9:20 pm - 9:25 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 9:00 am - 12:30 pm | GATING II |
| 9:00 am - 9:10 am | Discussion Leader: Pancho Bezanilla (University of Chicago) |
| 9:10 am - 9:35 am | Anthony Auerbach (SUNY Buffalo)
"Conformational Dynamics of AChR Gating" |
| 9:35 am - 9:45 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:55 am | Ramon Latorre (Centro de Estudios Cientificos)
"Molecular Basis of Temperature-Dependence in Thermo Transient Receptor Potential Channels" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:30 am | Sarah Lummis (University of Cambridge)
"Proline isomerisation as a mechanism to open the 5-HT3 receptor pore" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Breaking News: Vladimir M Yarov-Yarovoy (University of Washington)
"Voltage sensor conformations in the open and closed states in ROSETTA structural models of voltage-gated K+ channels" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:15 pm | Breaking News: Luis Cuello (University of Chicago)
"Spectroscopically driven structural model of KvAP in the open inactivated state embedded in a lipid bilayer" |
| 12:15 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ROLES IN BIOLOGY |
| 7:30 pm - 7:40 pm | Discussion Leader: Diane Papazian (University of California, Los Angeles) |
| 7:40 pm - 8:05 pm | Martin Chalifie (Columbia University)
"Regulation of ion channels by PHB-domain proteins and cholesterol" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Ching Kung (University of Wisconsin)
"Microbial Channels" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:10 pm | Peter Larsson (Oregon Health & Science University)
"Mode shifts in HCN channels: molecular mechanism and role in pacemaking" |
| 9:10 pm - 9:20 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
