Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: New Directions in Ion Channel Research |
| Discussion Leader: David Clapham (Harvard Medical School, USA) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:25 pm | Richard Tsien (New York University School of Medicine, USA) "Novel Modes of Information Transfer to Drive Neuronal Plasticity" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:10 pm | David Julius (University of California, San Francisco, USA) "Structural Insights into Pain Sensation" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Thermosensing Through Ion Channels |
| Discussion Leader: Magdalene Moran (Hydra Biosciences, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Jie Zheng (University of California, Davis, USA) "TRPV1 Activation by Vanilloids" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Ramon Latorre (University of Valparaíso, Chile) "Allosterism and Structure in Thermally-Activated
Transient Receptor Potential Channels" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Sharona Gordon (University of Washington, USA) "Measuring Confomational Dynamics in TRPV1 Using ncAA and tmFRET" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:40 am | Baron Chanda (University of Wisconsin-Madison, USA) "Hidden
in Plain Sight: A Plausible Mechanism of Temperature-Sensing" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Candice Paulsen (University of California, San Francisco, USA) "Structure of the TRPA1 Ion Channel Suggests Regulatory Mechanisms" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structure of Ion Channels |
| Discussion Leader: Brad Rothberg (Temple University School of Medicine, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Daniel Minor (University of California, San Francisco, USA) "How Do Channels Respond to Temperature?" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Donald Gill (Pennsylvania State University, USA) "Understanding the STIM-Orai Coupling Interface" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Rachelle Gaudet (Harvard University, USA) "Substrate Selectivity in Nramp-Family Transition Metal Transporters" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Ryan Hibbs (University of Texas Southwestern Medical Center, USA) "Nicotinic Acetylcholine Receptors" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanosensory Ion Channels |
| Discussion Leader: Miriam Goodman (Stanford University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Bailong Xiao (School of Pharmaceutical Sciences, Tsinghua University, China) "Structural and Functional Characterizations of the Mechanosensitive
Piezo1 Channel" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Jorg Grandl (Duke University, USA) "Mechanism of Activation and Modulation of Piezo
Ion Channels" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Ruhma Syeda (The Scripps Research Institute, USA) "Piezo1 Channels Are Inherently Mechanosensitive" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Slav Bagriantsev (Yale University, USA) "Neuronal Mechanoreception in Tactile Specialist Ducks" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Craig Montell (University of California, Santa Barbara, USA) "The Molecular and Cellular Basis of Gustatory Detection in Drosophila" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Francesco Tombola (University of California, Irvine, USA) "Mechanosensitivity
of the Hv1 Channel" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Modulation of Ion Channels |
| Discussion Leader: Ann Rittenhouse (University of Massachusetts Medical School, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Tibor Rohacs (Rutgers New Jersey Medical School, USA) "Regulation of Somatosensory Ion Channels by Phosphoinositides" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Bruce Bean (Harvard Medical School, USA) "Endocannabinoid Modulation of Dopamine Neuron Excitability" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Diomedes Logothetis (Virginia Commonwealth University, USA) "Phosphoinositide and G Protein Regulation of Inwardly Rectifying Potassium Channels" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Bonnie Wallace (Birkbeck, University of London, United Kingdom) "The Complete Crystal Structure of an Activated Open Sodium Channel" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ion Channels in Concert |
| Discussion Leader: Bertil Hille (University of Washington, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Mark Nelson (University of Vermont, USA) "Ion Channel Networks in the Control of Cerebral Blood Flow" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Diane Papazian (University of California, Los Angeles, USA) "Ion Channel Gating and Infant-Onset Neurological Diseases" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Polina Lishko (University of California, Berkeley, USA) "Steroids, Endocannabinoids and Ion Channels" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Andrea Meredith (University of Maryland School of Medicine, USA) "Molecular Mechanisms of Circadian Variation in BK Current Properties" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Mark Shapiro (University of Texas Health Science Center at San Antonio, USA) "Clustering
of Diverse Channels and Receptors in Sensory Neurons Revealed at the Single-Molecule Level by Super-Resolution Microscopy" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Assembly and Trafficking of Ion Channels |
| Discussion Leader: Carol Deutsch (University of Pennsylvania, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Gail Robertson (University of Wisconsin-Madison, USA) "Co-Translational Association of mRNA Encoding Heteromeric Ion Channels" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Paul Slesinger (Icahn School of Medicine at Mount Sinai, USA) "Psychostimulants Put GIRK Channels on the Move" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Thomas Baukrowitz (University of Kiel, Germany) "A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Eunyong Park (Rockefeller University, USA) "Structure and Mechanism of CLC Chloride Channels" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Engineering Ion Channels |
| Discussion Leader: Chris Ahern (University of Iowa, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Ehud Isacoff (University of California, Berkeley, USA) "Gating mGluRs" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | William Kobertz (University of Massachusetts Medical School, USA) "Fluorescent Visualization of Cellular Efflux" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Hongkang Zhang (Harvard University, USA) "Optical Electrophysiology for Probing Function and Pharmacology of Voltage-Gated Ion Channels" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Richard Kramer (University of California, Berkeley, USA) "Chemical Photosensitization of Voltage-Gated Ion Channels as a Strategy
for Restoring Vision to the Blind" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Andrew Plested (Leibniz Institute for Molecular Pharmacology, Germany) "Glutamate Receptors: Lights, Camera, Action" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Jian Payandeh (Genentech, Inc., USA) "How to Trap a Voltage-Sensor: Insights from Engineering Nav1.7-Selective
Inhibition" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Ion Channels / New Functions for Ion Channels |
| Discussion Leader: Andrea Brueggemann (Nanion Technologies, Germany) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:50 pm | Willem Laursen (Yale University, USA) "Diminished Heat Sensitivity of TRPV1 Supports Heat Tolerance in Ground Squirrels and Camels" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Ian Ramsey (Virginia Commonwealth University, USA) "Hv1 Proton Channel Gating" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Kevin Foskett (Perelman School of Medicine, University of Pennsylvania, USA) "CALHM Ion Channels in Taste Perception" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Christopher Miller (Brandeis University, USA) "A Weird Ion Channel for a Weird Ion" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |