Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Foundations of Membrane Excitability
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Structural Investigation of the Nav Channels"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Metabolic Regulation of the KATP Channel in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Channel Gating at High Resolution
9:00 am - 9:20 am
"Mechanisms Underlying Gating and Modulation of Serotonin (3A) Receptors"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Selectivity and Gating of Organellar Two-Pore Channels"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Ligand Modulation in CNG Channels"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
"Toward Understanding KATP Channel Gating: What Have We Learned from the Structures?"
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Cryo-EM Structures of the Endolysosomal Calcium Channel TRPML3 in the Open, Closed and Low pH-Inhibited States"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"A New View of Voltage Sensor Modulation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Calmodulin C-Lobe Ca2+ -Dependent Switch Governs Kv7 Channel Function"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Activation Mechanism of a Human SK-Calmodulin Channel Complex"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ion Channel Design Elements
7:30 pm - 7:50 pm
"Molecular Mechanisms of TRPV Channels Activation and Inhibition"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Deconstructing Oligomeric Assemblies of Membrane Proteins with Native Mass Spectrometry"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Re/De-Constructing Ubiquitin Regulation of Ion Channels"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"TRP Channels Undergo an Irrevesible Transition After Heat Activation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Structural Determinants of Inactivation in Mechanically Activated Piezo Ion Channels"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sensing and Gating Mechanisms
9:00 am - 9:20 am
"Mechanisms of Gating in Voltage-Gated Ion Channels"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"All-Optical Assays of Ion Channel Function"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Regulatory g1 Subunits Defy Symmetry in Functional Modulation of BK Channels"
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"A Mechanistic Perspective of Gating Charge Transfer in Voltage Sensing Domains"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Structure of the Cold and Menthol Sensor TRPM8"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Opening up New Opportunities by Combining High Throughput Electrophysiology with Optical Tools"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Mechanism of Calcium Dependent Phospholipid Transport by a TMEM16 Scramblase"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Thermodynamic Correction of the Predominant Disease-Causing F508del Mutation in Human CFTR"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Evolution of Electrical Signaling, Emergent Properties and Ion Channel Frontiers
7:30 pm - 7:50 pm
"Tuning Color, Kinetics and Selectivity of Light-Gated Ion Channels / Channelrhodopsins"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Unexpected Accessory Subunits of Neuronal Potassium Channels"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"There and Back Again: Evolution of Voltage Sensitivity in an Electric Fish Voltage-Gated Potassium Channel"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Structure and Function of a Metabolically-Regulated K+ Channel from Mycobacteria"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Takes Two to Tango: APOL1 Dimerization Drives Channel Formation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ion Channels in Organelles and Within Physiological Contexts
9:00 am - 9:20 am
"Intracellular Ion Channels Critical for Melanocyte Pigmentation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Mechanisms of Mitochondrial Thermogenesis"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Organelle Ion Channels and Lysosomal Excitability"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
"Otopetrins: An Evolutionary Conserved Family of Proton Selective Ion Channels"
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"The Functional Anatomy of Orai1 Channel Gating"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"TRPs Move into Uncharted Territory: TRP Channels as Ionotropic Hormonal Receptors"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Molecular Mechanism of the Mitochondrial Calcium Uniporter"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Cryo-EM Structure of the Mitochondrial Calcium Uniporter"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Anions, Allostery and Epithelial Conductances
7:30 pm - 7:50 pm
"Molecular Determinants of Selectivity in an Unusually Discerning Anion Channel"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Structure and Selectivity of a Volume-Regulated Anion Channel of the LRRC8 Family"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Molecular Evolution of the TRPM2 Channel and Insights into Gating Regulation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Structural Studies of Epithelial Sodium Channels"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Structural Study of CFTR, the Odd ABC Transporter Responsible for Cystic Fibrosis"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Biology at the Synapse
9:00 am - 9:20 am
"Structural Mechanisms of Gating in Ionotropic Glutamate Receptors"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Structural Principles of Neurotransmitter and Benzodiazepine Binding at the Human GABA-A Receptor"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Human GABAA Receptor Structures and Signaling Mechanisms"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
"Selective Pharmacological Modulation of Forebrain AMPA-Receptors: Success in the Development of TARP g-8-Dependent AMPA Receptor Antagonist, g-8 TDAA"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Conformation and Energy Landscape of Glutamate Receptor Probed by smFRET"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Proton-Dependent Gating Mechanisms of Acid-Sensing Ion Channels"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Semi-Synthetic Approach to Engineer Ion Channels in Live Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Fluorescent Visualization of Complement-Dependent Pannexin Activity in Microglia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Discoveries on the Ion Channel Horizon
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"High-Speed Atomic Force Microscopy Height Spectroscopy (HS-AFM-HS): Microsecond Dynamics of Unlabeled Biomolecules"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:40 pm
"Single Particle Cryo-EM of TRP Channels in Lipid Nanodisc"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:25 pm
"Piezo Ion Channels: Professional Mechanosensors"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure