SIGNALING PATHWAYS - TRANSDUCTION AND CROSS-TALK
- Chair: E. Erdös
- J. Schlessinger (New York, USA) - "A role for PYK2 in linking G protein-coupled receptors with MAP kinase signaling"
- H. Higashida (Kanazawa. Japan) - "Multiple pathways and cross talk in signal transduction of bradykinin B2 receptors in Ca2+ homeostasis"
- G. Burgess (London, United Kingdom) - "PGE2-induced sensitization of bradykinin-stimulated increases in [Ca2+]i, in neurones is mediated by cAMP"
- Dlscussant: B. Zuraw (La Jolla, USA)
G PROTEIN-COUPLED RECEPTORS - STRUCTURE AND FUNCTION
- Chair: D. Proud
- T. Schwartz (Copenhagen, Denmark) - "Elusive ligands: conformational interchange of receptors - binding without competition or without mutational hits"
- F. Leeb-Lundberg (San Antonio, USA) - "Binding studies on B1/B2 receptor chimeras reveal a role for TM domain-3 in ligand subtype speciflcity"
- C. Schroeder(Mainz, Germany) - "The ornithokinin receptor; a model system to study receptor activation and ligand binding of kinin receptors."
- Discussant: F. Alhenc-Gelas (Paris, France)
KININ ANTAGONISTS - CHEMISTRY AND PHARMACOLOGY
- Chair: B. Schölkens
- N. Inamura (Osaka, Japan) - "Discovery of a novel orally active B2 antagonist, FR173657, and development to a new drug"
- T. Griesbacher (Graz, Austrla) - "The pharmacology of the novel non-peptide antagonist, FR173657"
KININ RECEPTORS - REGULATION AND EXPRESSION
- Chair: D. Regoli
- M. Bouvier (Montreal, Canada) - "Molecular mechanisms involved In G protein-coupled receptor regulation"
- A. Faussner (Baltimore, USA) - "Role of the cytoplasrnic tail for internalization, sequestratlon and signaling of kinin receptors"
- F. Marceau (Montreal, Canada) - "Molecular basis of B1 receptor gene expression regulation"
- Discussant: P. Maddedu (Italy)
PEPTIDERGIC SYSTEMS - DISTRIBUTION AND FUNCTION
- Chair: W. Müller-Esterl
- F. Mendelsohn (Melboume, Australia) - "Localization of B2 receptors in multiple novel sites in the central nervous system - implications for functions"
- C. Figueroa (Valdivia, Chile) - "Occurence and distribution of kinin and endothelin receptors in the cardiovascular system""
- P. McNaughton (London, United Kingdom) - "Bradykinin and pain-sensitive neurones: excitation and sensitization"
CELLULAR SYSTEMS - RECEPTORS AND MEDIATORS
- Chair: A. Schmaier
- B. Ghebrehewit (Stony Brooks, USA) - "gC1qR - a multiligand binding membrane protein which recognizes high molecular weight kininogen"
- A. Hasan (Ann Arbor, USA) - "Cytokeratin is a binding protein for kininogens on endothelial cells and platelets"
- B. Colman (Philadelphia, USA) - "Blood and vessel cell receptors for kininogens"
- Discussant: J. Dedio (Mainz, Germany)
TRANSGENICS - KNOCK-OUTS AND KNOCK-DOWNS
- Chair: H. Margolius
- C. Wahlestedt (Montreal, Canada) - "Antisense strategies In receptor research"
- P. Geppetti (Ferrara, Italy) - "Control of plasma extravasation by peptidases and kinins: new insights from knock-out mice"
- J. Pesquero (Sao Paulo, Brazil) - "Molecular characterization and targeted disruption of the mouse bradykinin B1 receptor gene"
- Discussant: J. Chao (Charleston, USA)
CARDIOVASCULAR SYSTEM - MODELS AND MECHANISMS
- Chair: H. Fritz
- M. Paul (Berlin, Germany) - "Modelling of cardiovascular phenotypes in transgenic animals overexpressing peptidergic systems"
- T. Hintze (Valhalla, USA) - "Local kinin control of NO production and myocardial metabolism"
- T. Berg (Oslo, Norway) - "The role of K+ channels and intracellular Ca2+ in the hypotensive response to bradykinin"
- Discussant: G. Wiemer (Frankfurt, Germany)
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