Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanisms of Lipid Droplet Storage
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
General Discussion
8:05 pm - 8:35 pm
"Mechanisms Regulating Lipid Storage"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"The Other Lipoprotein: Cellular Lipid Droplets in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipoprotein Metabolism and Cardiometabolic Disease
9:00 am - 9:20 am
"Innate Adaptive Pathways Impacting Metabolic Health"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Gut–Liver Crosstalk Regulates Triglyceride-Rich Lipoprotein Clearance"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Mitochondrial Control of Cardiometabolic Health: Lessons Learned from Inborn Errors of Metabolism"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Role of HDL in Prevention and Treatment of Bacterial Sepsis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Genetic, Transcriptomic and Genomic Analyses of LXR Function in Hepatocytes and Macrophages Reveals Cell - and Gene-Specific Activities of Natural and Synthetic LXR Ligands"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Intra-Organelle Biology of Lipid and Lipoprotein Metabolism
7:30 pm - 7:50 pm
"Functional Genetics Regulating Lipid Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Cellular Dynamics of Membrane Lipid Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Understanding the Systemic Response to Choline Deficiency"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inter-Tissue Cross Talk in Lipid Metabolism
9:00 am - 9:20 am
"Secreted Mediators of Dietary Lipid Stress and Exercise in Heart and Muscle Metabolism"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Cardiometabolic Phenotypes in TM6SF2 Variant Mice"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Understanding the Role of Membrane Lipids in Liver Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Lipid Droplets and the Compartmentalization of Metabolism"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Lipids as a Driver of Inflammation: Mechanisms, Consequences and Opportunities"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Interventions for Lipid and Lipoprotein Metabolism
7:30 pm - 7:50 pm
"Development of Single Course Gene Editing Therapies to Treat Cardiovascular Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Activin Receptor Signaling and Lipid Homeostasis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Emerging Therapeutic Strategies in MASH"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Interplay Between Bile Acids, Gut Microbiome, and Lipoprotein Metabolism
9:00 am - 9:20 am
"Bile Acid Transport and Enterohepatic Cycling: Trying to Understand the Physiology and Connections to Lipid Metabolism with the Hope of Helping Patients"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Ecology and Engineering to Modify the Bile Acid Output of the Gut Microbiome"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The Role of the Gut Microbiome in Lipid Metabolism"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Life’s Book, Mostly Blank: Uncovering 100,000s of New Lipids and Bile Acids"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Gut Microbiome Lipid Metabolism and its Impact on Host Physiology"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipoprotein Structure and Function
7:30 pm - 7:50 pm
"Rethinking HDL in the Age of AI: Next‑Generation Mapping of Proteomic Signatures in Cardiometabolic Health"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Structure of Apolipoprotein B100 on Low-Density Lipoprotein Bound to the LDL Receptor"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The HDL Proteome in Cardiometabolic Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Structure of HDL as Visualized by Antibody Assisted Cryo Electron Microscopy"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Lipoprotein Metabolism in Neurodegenerative Diseases
9:00 am - 9:20 am
"Lipid Metabolism Disruption: A Key Driver Of Alzheimer’s Disease Risk Genes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Lipotoxic Mechanisms in Neurodegeneration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"The Role of HDL Metabolism in Traumatic Brain Injury"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"The Cellular Biology of ApoE: Key to Alzheimer’s Disease Prevention"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Concepts in Metabolic Dysfunction-Associated Steatotic Liver Disease
7:30 pm - 7:50 pm
"Cellular Crosstalk Mechanisms in MASH Fibrosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Metabolism and Therapeutic Potential of N-Acyl Amino Acids in MASH and Atherosclerosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Mechanisms of Altered SREBP Regulation in MASLD"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure