Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Building Lymphatics |
| Discussion Leader: Anne Eichmann (Yale School of Medicine, USA) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 8:05 pm | Benjamin Hogan (University of Queensland, Australia) "New Mechanisms of Lymphatic Vascular Development from Zebrafish" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Mark Kahn (University of Pennsylvania, USA) "Molecular Regulation of Lymphatic Development" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Guillermo Oliver (Northwestern University, USA) "The Specification of Lymphatic Fate, a Key Step in Lymphatic Development" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Stefan Schulte-Merker (Westfälische Wilhelms-Universität Münster, Germany) "Novel Genes Essential for Lymphangiogenesis in Fish and Mice" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | The Interstitial Microenvironment and Recent Focus on Interstitial Flow in the Brain |
| Discussion Leader: Melody Swartz (University of Chicago, USA) |
9:00 am - 9:20 am | Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland) "Are Dural Lymphatics Involved in Neuropathology?" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Jonathan Kipnis (University of Virginia, USA) "Lymphatics in the Central Nervous System" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Samia Bachmann (ETH Zurich, Switzerland) "In Vivo Regulation of Lymphatic Vessel Function by the Autonomous Nervous System" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Masataka Majima (Kitasato University School of Medicine, Japan) "Roles of RAMP-1 Signalling as a Neuronal Cue of Lymphangiogenesis" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Jens Titze (Vanderbilt University, USA) "Sodium and the Microenvironment Inside and Outside the Lymphatics" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Helge Wiig (University of Bergen, Norway) "On the New Role of the Interstitium and Lymphatics in the Development of Hypertension" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Cathryn Kolka (Cedars-Sinai Medical Center, USA) "The Lymphatic System as a Tool for the Study of Insulin Trafficking in Interstitial Fluid of Skeletal Muscle" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Hector Peinado (Spanish National Cancer Research Centre (CNIO), Spain) "Exosomes Shed by Tumor Cells into the Interstitium Transit to LNs and Reprogram the Microenvironment" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Collecting Lymphatic Vessels and Mechanics |
| Discussion Leader: David Zawieja (Texas A&M University, USA) |
7:30 pm - 7:50 pm | Tatiana Petrova (Lausanne University Hospital / University of Lausanne, Switzerland) "Biomechanical and Transcriptional Regulation of Lymphatic Vessel Function" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Michael Davis (University of Missouri School of Medicine, USA) "KATP Channels Are an Important Component of Lymphatic Dysfunction in Cantu Syndrome" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Brandon Dixon (Georgia Institute of Technology, USA) "Lymphatic Remodeling as a Driving Force in Collecting Vessel Pump Failure in Lymphedema" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Niklas Telinius (Aarhus University Hospital, Denmark) "Voltage-Gated Sodium Channels Contribute to Action Potentials and Spontaneous Contractility in Isolated Human Lymphatic Vessels" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Joshua Scallan (University of South Florida, USA) "Regulation of Collecting Lymphatic Vessel Permeability by Dendritic Cells Expressing CCR7 and IRF4" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Lymph Node and Lymphatics in Immunity |
| Discussion Leader: Nancy Ruddle (Yale School of Public Health, USA) |
9:00 am - 9:20 am | Jason Cyster (University of California, San Francisco, USA) "Lymph Node Lymphatic Sinuses and Immunity" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Reinhold Forster (Hannover Medical School, Germany) "Migration of Lymphocytes into and Within Lymph Nodes" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | James Moore (Imperial College London, United Kingdom) "Analysis of Fluid Flow Through Lymph Nodes" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Lijun Xia (Oklahoma Medical Research Foundation, USA) "Signals Governing Lymph Node Integrity" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Shannon Turley (Genentech, USA) "Podoplanin Function in Lymphoid Stroma" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Melody Swartz (University of Chicago, USA) "Lymphatics in Immune Modulation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Beth Tamburini (University of Colorado Anschutz Medical Campus, USA) "Contraction of the Hypertrophic Lymph Node and Death of Lymphatic Endothelial Cells as a Process for Antigen Exchange" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetics and Lymphedema |
| Discussion Leader: Stanley Rockson (Stanford University School of Medicine, USA) |
7:30 pm - 7:50 pm | Miikka Vikkula (de Duve Institute, Université Catholique de Louvain, Belgium) "Genes Implicated in the VEGFR3 Signaling Pathway Explain 30% of Primary Lymphedema" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Sahar Mansour (St. George's, University of London, United Kingdom) "Two New Genetic Disorders Presenting with Lymphatic-Related Hydrops Fetalis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Babak Mehrara (Memorial Sloan-Kettering Cancer Center, USA) "Cellular Mechanisms of Lymphatic Regeneration and Dysfunction in Lymphedema" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Marco Borri (CR-UK Cancer Imaging Centre / Royal Marsden NHS Foundation Trust / Institute of Cancer Research, United Kingdom) "Magnetic Resonance for Improved Understanding of Collecting Lymphatic Vessels Morphology and Tissue Composition in Breast Cancer Related Lymphedema" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Barbara Garmy-Susini (Inserm, France) "Beneficial Effect of Estrogen on Lymphatic System Is Inhibited by Hormone Therapy to Promote Lymphedema" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signals that Regulate the Lymphatic Vasculature in Development, Health, and Cancer / Advances in Imaging |
| Discussion Leader: Gou Young Koh (Korea Advanced Institute of Science and Technology, South Korea) |
9:00 am - 9:20 am | Karina Yaniv (Weizmann Institute of Science, Israel) "Building Lymphatic Vessels in Vertebrates: Insights from Zebrafish" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Anne Eichmann (Yale School of Medicine, USA) "Neuropilin Regulation of Lymphatics" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Steve Watson (Birmingham University, United Kingdom) "CLEC-2 and Podoplanin Crosstalk Between Platelets and Lymphatics" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:40 am | Natasha Harvey (Centre for Cancer Biology, University of South Australia, Australia) "Control of Lymphatic Valve Morphogenesis by Gata2" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Michael Detmar (ETH Zurich, Switzerland) "Important Roles of Lymphatic Vessels in the Control of Inflammation and the Promotion of Distant Cancer Metastasis" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Mihaela Skobe (Icahn School of Medicine at Mount Sinai, USA) "Lymphatic Metastasis and Metastatic Efficiency" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Eelco Meijer (Massachusetts General Hospital, USA) "In Vivo Label-Free Measurement of Lymph Flow Velocity and Volumetric Flow Rates Using Doppler Optical Coherence Tomography" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Rene Haegerling (Max Planck Institute for Molecular Biomedicine, Germany) "A Novel Imaging Approach for the 3D Visualization of Blood and Lymphatic Vasculature in Healthy and Lymphoedema Affected Humans" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Lymphangioleiomyomatosis (LAM) and mTOR in Lymphatic Biology |
| Discussion Leader: Mark Kahn (University of Pennsylvania, USA) |
7:30 pm - 7:50 pm | Frank McCormack (University of Cincinnati, USA) "Lymphatic Manifestations of Lymphangioleiomyomatosis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kuniaki Seyama (Juntendo University, Japan) "Isolation and Characterization of LAM Cells" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Lisa Henske (Harvard Medical School, USA) "Role of Cellular Metabolism and Autophagy in Lymphangioleiomyomatosis (LAM): From Pathogenesis to Targeted Therapy" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Donald McDonald (University of California, San Francisco, USA) "Rapamycin Reversal of Lymphangiectasia in a Mouse Model" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lymphatics in the Intestine, Mesentery, and Visceral Fat |
| Discussion Leader: Gwendalyn Randolph (Washington University in St. Louis, USA) |
9:00 am - 9:20 am | Taija Makinen (Uppsala University, Sweden) "Organ-Specific Origins of the Lymphatic Vasculature" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Natasza Kurpios (Cornell University, USA) "Dual Origin of Intestinal Lymphatic Vasculature Is Established via Integration of Pitx2 and Cxcl12/Cxcr4 Chemotaxis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Gou Young Koh (Korea Advanced Institute of Science and Technology, South Korea) "Intestinal Lymphatic Lacteals" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:40 am | Jeremiah Bernier-Latmani (University of Lausanne, Switzerland) "Mechanisms of Notch Signaling in Adult Intestinal Lacteals" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Jean-Frederic Colombel (Mount Sinai School of Medicine, USA) "Clinical and Experimental Observations Implicating a Role for Lymphatic Vessels in Crohn's Disease" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Sonia Rehal (University of Calgary, Canada) "Intestinal Lymphatic Pathology and Lymph Transport in Mouse Crohn's Disease-Like Ileitis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Reema Davis (University of North Carolina at Chapel Hill, USA) "Lymphatic Vessels in Intestinal Inflammation and Repair" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Joseph Rutkowski (Texas A&M Health Science Center, USA) "Adipose Tissue VEGF-D Overexpression Induces Local Lymphangiogenesis and Altered Lipid Handling" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jerome Breslin (University of South Florida, USA) "Remodeling of Mesenteric Collecting Vessels in Juvenile, Obese Zucker Rats" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lymphatics in the Cardiovascular System |
| Discussion Leader: Natasha Harvey (Centre for Cancer Biology, University of South Australia, Australia) |
7:30 pm - 7:50 pm | Paul Riley (University of Oxford, United Kingdom) "Heterogeneity of Lymphatics in the Heart and Its Implications" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kathleen Caron (University of North Carolina, USA) "Adrenomedullin in Cardiac and Lymphatic Development" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Michael Dellinger (University of Texas Southwestern Medical Center, USA) "Overexpression of VEGF-C in Bone Induces a Gorham-Stout Disease-Like Phenotype" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Seppo Yla-Herttuala (University of Eastern Finland, Finland) "Lymphatics and Atherosclerosis" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Elizabeth Haining (University of Birmingham, United Kingdom) "A Novel Knock-In Mouse Reveals an Essential Role for the CLEC-2 hemITAM in Development" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |