Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Paradigm Shifts in Lymphatic Biology and Disease
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"Growth-Factor Regulation of Brain-Draining Lymphatics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Novel Lymphatic-Related Cells in the Brain"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Molecular and Functional Characterization of Macromolecular Uptake by Meningeal Lymphatic Endothelial Cells"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lymphatic Vessel Development and Heterogeneity
9:00 am - 9:20 am
"VEGFR3 Regulates Sprouting Lymphangiogenesis Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Transcriptional Control of Lymphatic Endothelial Cell Identity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Matrix Stiffness Controls Lymphangiogenic Growth Factor Responsiveness and Lymphatic Vessel Formation via GATA2"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
"New Cellular Functions and Developmental Pathways for Lymphatic Endothelial Cells in Zebrafish"
10:35 am - 10:45 am
Discussion
10:45 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Rasip1, a Novel Player Regulating Lymphatic Vessel Lumen Maintenance and Valve Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Foxc1/Foxc2 Regulation of Postnatal Lymphatic Valve Maturation and Lymphangiogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Using Optogenetics to Uncover Mechanisms of Pacemaking in the Lymphatic Vessel Wall"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Platelets Play a Role in Peripheral Blood-Lymph Partitioning via TGF-Beta"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Molecular Regulators of Lymphangiogenesis and Lymphatic Remodeling
6:00 pm - 6:20 pm
"Roles of Lymphatic Vessels in the Postnatal Lung"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"New Insights into the Control of VEGFR2/R3 Heterdimerization During Pathological Lymphangiogenesis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"New Key Players for Lymphangiogenesis and Lymphatic Identity"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"A Key Proteoglycan Co-Receptor in Lymphatic Remodeling and Dendritic Cell Function"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Role of Prostanoids in Regulation of Pathological Lymphangiogenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Organ-Specific Lymphatic Function and Pathology
9:00 am - 9:20 am
"Development and Maintenance of Organ-Specific Lymphatic Vasculature"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Strategies for Reversing Abnormal Lymphangiogenesis in Mouse Models"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Lymphatic Heterogeneity and Function in Specialized Vascular Beds"
10:20 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Role of Microbiota in Lacteal Integrity"
10:40 am - 10:45 am
Discussion
10:45 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Lymphatic Endothelial Cells Control Lymph Node Formation"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"The 3D Architecture of Lymph Node Blood Vessels"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Ocular Lymphatics and Therapeutic Intervention"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Lymphatic Expansion and Differentiation During Chronic Liver Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymphatics in the Brain and Beyond
6:00 pm - 6:20 pm
"Role of Meningeal Lymphatics in Neurological Disorders"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Outflow of Cerebrospinal Fluid Through Lymphatic Vessels Is Increased During Waking Conditions"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Development and Plasticity of Meningeal Lymphatic Vessels"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Angiopoietin-Tie2 System for Formation of Schlemm's Canal"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lymphedema and Congenital Lymphatic Diseases
9:00 am - 9:20 am
"Mutations-Related Primary Lymphedema"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Understanding Human Lymphatic Phenotypes Based on Gene Function and Mechanisms"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Notch4 Mutant Mice Develop a Lipedema-Like Syndrome Associated with Dermal Lymphatic Defects"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"New Insights into Mechanisms Underlying PIK3CA-Driven Vascular Malformations from Genetic Mouse Models"
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Novel Methods for Diagnosis and Treatment of Secondary Lymphedema"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Imaging and the Therapeutic Intervention of Lymphatic Flow Disorders"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Characterization of Lymphatic Function and Remodeling Response Following Lymphatic Injury"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Sustained Collecting Lymphatic Vessel Dysfunction After MRSA Infection"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cross-Talk Between the Lymphatics and the Immune System
6:00 pm - 6:20 pm
"Chronic Inflammatory Diseases and Recirculation of Lipoproteins Through the Interstitium"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Lymphatic-Endothelial S1P and T-Cell Survival"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"PD-L1 Regulation of Lymphatic Growth and Survival in the Lymph Node During an Immune Response"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"LYVE-1: A Docking Receptor for Leukocyte Entry and Trafficking in Skin Lymphatics"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Transcriptional Profiling of Afferent Lymphatic Capillaries and Collectors Reveals a New Entry Site for Dendritic Cell Migration to Lymph Nodes in Inflammation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Lymphatics in Cardiovascular Medicine and Metabolism
9:00 am - 9:20 am
"Inflammatory Lymphangiogenesis Helps Shape Adaptive Immunity: New Insights for Translation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Novel Tools to Image Lymphatic Vessel Development, Function and Dysfunction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Metabolic Regulation of Lymphatic Development and Lymphangiogenesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Lymphatic System: A Novel Actor in Cancer-Associated Cachexia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Role of Tryptophan Metabolites in Lymphatic Endothelium"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Role of Ketone Body Oxidation in Lymphangiogenesis: Possible Relevance for Lymphedema"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Molecular Mechanisms of Lymphangiogenesis in Diabetes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:30 pm
"Tumor-Associated Lymphatic Vessels and Immunosuppression in Cancer"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Host Regulators of Metastatic Colonization"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Role of the Lymphatic Vasculature in Regulating Tumor Exosome Trafficking and Production"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Fluid Outflow from the Central Nervous System via Lymphatic Vessels Is Reduced in Glioblastoma"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure