Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
A Multiscale View of Lymphatic Form and Function
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Vessel-Type–Specific Mechanisms Underlying Lymphatic Growth and Resilience"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Meningeal Lymphatic–Macrophage Axis Regulates Blood–Brain Barrier Integrity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Developmental Origins of Lymphatic Endothelium"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Tissue Specific Immunity from the Lymph Node Perspective"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lymphatic Vascular Development
9:00 am - 9:20 am
"Defining the Mechanisms by which Lymphatic Endothelial Cell Identity is Programmed"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"TLL1 Is a Novel Regulator of Lymphatic Development"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Left-Right (LR) Asymmetric Construction of the Villus Lymphatic Muscle"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Paraxial Mesodermal Cells Do Not Contribute to the Lymphatic Vasculature"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Decoding Lymphatic Endothelial Cell Differentiation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A Novel Role for Second Heart Field Progenitors in Lymphovenous Valve Development: Linking Cardiac and Lymphatic Development Through Shared Lineages"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Evolutionary and Developmental Plasticity of Lymphatic Endothelial Cells"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymphatic Mechanotransduction and Quantitative Biology
6:00 pm - 6:20 pm
"Mechanosensing in Lymphatic Endothelial Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Single-Cell Transcriptomics and Lineage Tracing Unveil Parallels in Lymphatic Muscle and Venous Smooth Muscle Development, Identity, and Function"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Mechano-Cellular Programs in Lymphatics"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"High-Intensity Exercise Drives Dose-Dependent Restoration of Lymphatic Contractility"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Guidance of Cell Migration by Lymphatic Endothelium"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Understanding and Targeting Lymphatics
9:00 am - 9:20 am
"Towards Clinical Translation of VEGF-C"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Biomechanical Regulation of Peyer’s Patch Lymphatic Vessel Development and Function"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Molecular Mechanisms Underlying the Pathogenesis of Complex Lymphatic Anomalies"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Regulation of Growth Factor Responsiveness in Quiescent Lymphatic Endothelium"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Therapeutic Discovery Platforms for Lymphatics: From Omics to the Clinic"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"NOTCH4 Maintains Dermal Capillary Lymphatic Endothelial Cell Fate to Sustain Lymphatic Regeneration and Homeostasis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Novel Roles of Reelin During Cardiac Growth and Repair"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Organ-Specific Lymphatic Vessels
6:00 pm - 6:20 pm
"Mapping of Cerebrospinal Fluid Lymphatic Outflow Pathways from the Brain and Spine"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Piezo2-Vegfr3 Signaling Axis Regulates Expansion of Adipose Tissue in Obesogenic Conditions via Lymphangiogenesis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Increased CSF Outflow by Non-Invasive Stimulation of Cervical Lymphatics"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Lymphatic Vasculature Niche Supports Stem Cell for Craniofacial Tissue Regeneration"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"NOTCH1 Is Required for Button Junction Development"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"The Role of Lung Lymphatic Unzipping in Regulating the Host Response to Lung Injury"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lymphatics and Immune Surveillance of Tissues
9:00 am - 9:20 am
"Lymphatic Vascular Organization and Specialization in Human Skin"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Uncovering Lymphovascular Heterogeneity in Primary Lymphoedema"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Central Lymphatic Outflow from the Intestine"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Lymphatics Unload VEGFR3 in Response to Endothelial Stress Upon VEGFR2 Insufficiency"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Circadian Leukocyte Egress from Tissues"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Lymphatic Endothelial Cell Junctions in Lymph Nodes Are Modulated by Immunization"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Lymphatic Vessels in Cancer and Injury"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Lymphatic Endothelial Cells as Immunomodulators in Cancer"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Integrated Single-Cell and Spatial Transcriptomics Reveals Organ-Specific Lymphatic and Blood Vascular Signalling Niches Preceding Cancer Metastasis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Lymphatic Transport Maintains a Dynamic Progenitor T Cell Niche in Melanoma"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Role of the Afferent Lymph as an Immunological Conduit to Analyze Tissue Antigenic and Inflammatory Load"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Aging-Induced Changes in Anti-Cancer Immune Responses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Genetics and Biology of Lymphedema
9:00 am - 9:20 am
"Novel Genetic Causes of Complex Lymphatic Anomalies"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Adipose-Depot Specific Lymphatic Dysregulation in Women With Lipedema"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Lymph Node Remodeling in Cancer: From Pre-Metastatic Niche Formation to the Pathophysiology of Lymphedema After Lymphadenectomy"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Pathogenic Loss-of-Function Variants of Ribosomal Protein RPL10A Cause Milroy-Like Primary Lymphedema"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"New Genes in Old Pathways"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Exercise Rescues Lymphatic Contractility by Promoting Sympathetic Re-Innervation in Secondary Lymphedema"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Improving the Diagnostic Yield of Primary Lymphatic Anomalies"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymph Transport and Drug Delivery
6:00 pm - 6:20 pm
"Progress on a Glyceride Mimetic Prodrug Strategy to Deliver Drugs to Mesenteric Lymph"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Delivery of VEGFC mRNA With Lymphatic Targeting Lipid Nanoparticles in a Radiation-Induced Rat Model of Irreversible Lymphedema Drives Lymphatic Repair and Reverses Swelling"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"The Contractile and Transcriptional Consequences of Store-Operated Calcium Entry Activation (SOCE) in Mouse Lymphatic Muscle Cells"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Loss of Myogenic Activity in Smooth Muscle Cells Drives Lymphatic Malformations"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Mechanism of Lymphatic Transport Tunes Potency of Immune Signaling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure