Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Endosomes and Lysosomes in Cellular Function and Metabolic Regulation
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
"Lysosomes and Endocytosis: Learning from the Professionals"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
"Endocytosis in Systemic Metabolic Regulation"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diversity of Endolysosomal Function and Organelle Crosstalk
7:30 pm - 7:40 pm
"Structural Insights for Activation of mTORC1 on the Lysosomal Membrane"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"A Lysosome-Associated Ribosome-mTORC1 Assembly Regulates Local Protein Synthesis in Neurons"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Spatial Regulation of Lysosomal Vesicle Acidification Along the Axon via mRAVE-Dependent v-ATPase Assembly"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"SNX14 Family Proteins Maintain Lysosome Membrane Integrity, Defective in Cerebellar Ataxias"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Disease-Causing Mutations in CSPa Reduce Lysosomal Exocytosis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Promoting Rab7 Activity Protects Cells Against Chronic Iron Overdose and Ferroptosis by Stimulating Lysosome Motility and Mitophagy Flux"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"DMT1-Mediated Inter-Organelle Iron Trafficking Controls Ferroptosis Sensitivity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Mechanism of Lysosomal Damage Caused by Mitochondrial Protein Import Stress"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Molecular Machinery of Endocytosis and Endolysosomal Membrane Traffic
9:00 am - 9:10 am
"Isoform-Specific Loading of VEGFA onto Extracellular Vesicles via Distinct Endolysosomal and Plasma Membrane Pathways"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Structural Diversity of Flat and Curved Clathrin Coats at the Plasma Membrane by Cryo-electron Tomography"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"The Development of Super-Resolution CLEM to Study AP3 in Secretory Granule Formation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"From Mystery Protein to SNARE Regulator: PTTG1IP’s New Role in Endolysosomal Dynamics"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"VPS45 Binding Sites Regulate Rabenosyn-5 and Syntaxin 16 Binding in Endosomal Membrane Trafficking"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Molecular Basis of VARP-Dependent SNX27 Supercomplex Assembly on Endosomes"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"USP32: A Key Player in the Biogenesis and Membrane Dynamics of Lysosomes"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Modulation of the WASH Complex is Driven by the Direct Interaction Between RAB21 and SWIP"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Endosomes and Lysosomes in Physiology and Disease
1:30 pm - 1:40 pm
"Examining the Role of CLN1 and 5 in the Regulation of Lysosomal and Synaptic Proteostasis Through Palmitoylation"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
"Ultrastructural Studies Reveal a New Role for JIP3/MAPK8IP3 in Endo-Lysosomal Maturation Within the Neuronal Cell Body"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
"Aging-Related Functions of the Autophagy Protein ATG16 and its WD40 Domain"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
"CASM-Dependent FLCN Sequestration Enhances Metabolic Flexibility in Pancreatic Cancer"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes