Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Initiation, Progression, and Prevention of Breast Cancer
Discussion Leaders: Min Yu (University of Southern California, United States)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:50 pm
Kornelia Polyak (Dana-Farber Cancer Institute, United States)
"Prevention of Breast Tumor Initiation and Progression"
8:50 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mapping Normal and Diseased States
Discussion Leader: Geoffrey Wahl (The Salk Institute for Biological Studies, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Nienke Bosschaart (University of Twente, The Netherlands)
"Optical Imaging and Sensing in Human Lactation"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Nicholas Navin (University of Texas MD Anderson Cancer Center, United States)
"A Single Cell and Spatially Resolved Atlas of the Adult Human Breast Tissue"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Jorge Reis-Filho (Memorial Sloan Kettering Cancer Center, United States)
"Breast Cancer and Pre-Cancer: An Integrated Pathology and Genomics Perspective"
11:20 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Lindsay Hinck (University of California, Santa Cruz, United States) and D. Joseph Jerry (University of Massachusetts / Pioneer Valley Life Sciences Institute, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nutrients and Metabolism in Normal and Cancer
Discussion Leader: Jenifer Monks (University of Colorado Anschutz Medical Campus, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Alex Toker (Beth Israel Deaconess Medical Center, United States)
"Targetable Vulnerabilities in Triple Negative Breast Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
John Wysolmerski (Yale University School of Medicine, United States)
"Calcium Handling by the Mammary Gland in Lactation and Breast Cancer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Erik Nelson (University of Illinois, United States)
"Using Diet to Reveal New Cellular and Pharmacologic Mechanisms Regulating Breast Cancer Progression"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Hormonal and Systemic Regulation of Normal Biology and Cancer
Discussion Leader: Leonie Young (Royal College of Surgeons in Ireland, Ireland)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Lindsay Hinck (University of California, Santa Cruz, United States)
"Physiological DNA Damage Regulates Lactation"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Pepper Schedin (Oregon Health and Science University, United States)
"Weaning-Induced Mammary Gland Involution Informs Breast Cancer Metastases to the Live"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Myles Brown (Dana-Farber Cancer Institute, United States)
"Role of RNA Methylation in Mammary Differentiation and Tumor Suppression"
11:20 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microbiome and Inflammation in Normal Biology and Cancer
Discussion Leader: Walid Khaled (University of Cambridge, United Kingdom)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
David Mills (University of California, Davis, United States)
"Lessons Learned from a Naturally Evolved System to Enrich a Functional Microbiome: The Wonders of Mammalian Milk"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Dipali Sharma (Johns Hopkins, United States)
"Unraveling the Mechanistic Connections Between Microbiome and Breast Cancer: An Ever-Evolving Story"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Mikala Egeblad (Cold Spring Harbor Laboratory, United States)
"Chronic Stress Causes Breast Cancer Metastasis via Neutrophil-Mediated Changes to the Microenvironment"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microenvironmental Modulation of Development and Cancer
Discussion Leader: Heather Machado (Tulane University School of Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Xiang Zhang (Baylor College of Medicine, United States)
"Molecular and Cellular Profiling of Bone Metastasis Niches"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Philipp Scherer (University of Texas Southwestern Medical Center, United States)
"Mammary Adipose Tissue: From Metabolism to Cancer"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Michael Angelo (Stanford University School of Medicine, United States)
"A Spatial Framework for Predicting Single Cell Function and Clinical Outcome in Breast Cancer"
11:20 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immune Modulation in Normal Biology and Cancer
Discussion Leader: Kaylee Schwertfeger (University of Minnesota, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Forest White (Koch Institute for Integrative Cancer Research, MIT, United States)
"Phosphoproteomics Reveals Patient-Specific Signaling Networks in Triple Negative Breast Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Marcia Haigis (Harvard Medical School, United States)
"The Role of Metabolites in the Tumor Microenvironment"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Tomonori Nochi (Tohoku University, Graduate School of Agricultural Science, Japan)
"The Gut Microbiota Induces Peyer's-Patch-Dependent Secretion of Maternal IgA into Milk"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mechanisms Regulating Metastasis
Discussion Leader: Heide Ford (University of Colorado Anschutz Medical Campus, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Li Yang (NCI, United States)
"Uncovering Nuclear Expulsion of Tumor Cells: Chromatin-Bound S100a4 and Metastatic Outgrowth"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
Min Yu (University of Southern California, United States)
"Circulating Tumor Cells Inform Mechanisms of Breast Cancer Metastasis"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Yibin Kang (Princeton University, United States)
"Functional Mechanism and Therapeutic Targeting of Cancer Fitness Gene MTDH in Breast Cancer"
11:20 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Jayanta Debnath (University of California, San Francisco, United States)
"Autophagy and Pro-Metastatic Differentiation in Breast Cancer"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Lifestyle, Genetic Factors and Breast Cancer Etiology
Discussion Leader: D. Joseph Jerry (University of Massachusetts / Pioneer Valley Life Sciences Institute, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:45 pm
A. Heather Eliassen (Harvard TH Chan School of Public Health, United States)
"The Role of Modifiable Factors in Breast Cancer Risk and Survival"
8:45 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure