Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Metalloproteinases in the Clinic
7:40 pm - 8:20 pm
"The Comeback of MMPs in Therapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Making the Case for GS-5745, an Anti-MMP9 Antibody Currently in Cancer Clinical Trials"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Rehabilitating a Lost Drug - The Story of Thalidomide"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metalloproteinases in Tissue Remodeling
Session in memory of Dr. Roger Tsien.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Protease-Triggered Cancer Imaging and Therapy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
"Could Life-Long Memory Be Encoded in the Pattern of Holes in the Perineuronal Net?"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Using an MMP-Cleavable Fluorescently Labeled Ratiometric Activatable Cell Penetrating Peptide (RACPP) for the Early Detection of Oral Cancer"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Coffee Break
10:25 am - 10:45 am
"Regulation of Organ Regeneration and Fibrosis by Vascular-Derived MMPs"
10:45 am - 10:55 am
Discussion
10:55 am - 11:15 am
"ADAM10 Substrates and Functions in Axon Targeting and Myelenation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"MT-MMPs, New Actors and Potential Targets in Alzheimer's Disease"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"ADAMTS-3 Inactivates Reelin, an Important Regulator of Brain Development and Function"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"The Role of Tissue Inhibitors of Metalloproteinases in Pulmonary Microvascular Endothelial Cell Barrier Dysfunction During Sepsis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Beyond the Catalytic Site: Endogenous Regulation of ADAM Activity
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Molecular Mechanisms and Biological Roles of iRhom/ADAM17 Signaling"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Regulation of ADAM10 by Tetraspanins"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Physical and Functional Interaction Between the Alpha- and Gamma-Secreatases: A New Model of Regulated Intramembrane Proteolysis"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Structural Basis for Regulated Proteolysis by the Alpha-Secretase ADAM10"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
MMPs and TIMPs as Targets
and Anti-Targets in Cancer
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"TIMP-1 Signaling as an Accomplice in Liver Metastasis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"A Perplexing Target: Opposing Functions of MMP10 in Colon Cancer"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
"Tumor Associated Macrophage MMP12 Cleaves Intracellular Tumor Oncogene Targets Preventing Cancer Inititiation"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:25 am
"Regulation of Tumor Microenvironmental Factors by ADAM28"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A Proteolytic ECM-Remodeling Axis Governs Breast Tumor Cell Invasion and Metastasis In Vivo "
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Loss of ADAM9 Expression Impairs β1 Integrin Endocytosis, Focal Adhesion Formation and Cancer Cell Migration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"The Metalloproteinase ADAM15 Is Upregulated by Shear Stress and Promotes Survival of Endothelial Cells"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
MMPs: Critical Effectors in Inflammation
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"MMP10 Drives the Immunosuppressive Activity of Macrophages"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"MMP1 Signaling Through Protease-Activated Receptor-1 in Systemic and Vascular Inflammation"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"MT-MMP Sheds LYVE-1 and Suppresses VEGF-C Production to Inhibit Lymphangiogenesis"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Post-Translational Truncation of IFN-? Dampens Proinflammatory Macrophage Responses and Is Reduced in Autoimmune Disease"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Approaches to Translate Discoveries to Targeted Therapies
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Systemic TIMP2 Treatment Improves Hippocampal Function in Aged Mice"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Unique Activity Profiles of Inflammatory Proteases"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
"MMP Structural Biology for Guiding Selective Inhibitor Design"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:30 am
"Development of Therapeutic TIMPs Integrating Structure-Based and Directed Evolution Approaches"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Deciphering Matrix Metalloproteinase Activation Networks in Tissue Repair by Targeted Degradomics"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Selective Inhibition of Cancer Cell Signalling by Targeting an Active Form of the ADAM10 Metalloprotease in Tumours"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"A Structure-Derived Snap-Trap Mechanism of a Multispecific Serpin from the Dysbiotic Oral Microorganism Porphyromonas gingivalis "
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Exploiting Metalloproteinase Activity for Diagnosis and Treatment of Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Exploiting Tumor Metalloproteinase Expression for Selective Drug Targeting"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Gelatinase B or MMP-9: From Target to Useful Disease Marker"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"MMPis as a Tool for Functional Lung Imaging"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"ADAMTS9 and ADAMTS20 Have a Dual Role in the Primary Cilium and ECM Remodeling During Morphogenesis"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Beyond the Catalytic Site: Endogenous Regulation of Metalloproteinases
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"MT1-MMP Transport and Structural Memory in Macrophages"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Exocyst-Dependent Control of MT-MMP Trafficking: The Trans-Golgi-to-Invadapodia Highway"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
"Signalling Through the Collagen Receptor, DDR1, Is Required for Epithelial Polarisation and Morphological Remodelling in 3D Collagen Matrices"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Shedding and Activation of Meprin Beta Regulates Intestinal Host Defense"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
General Discussion
11:45 am - 11:55 am
"Characterization of the Metalloproteinase ADAMTS16 and Its Role in Fibronectin Assembly"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"MUC-1 SEA Domain Shedding Protease, Matrilysin, Mediates Nucleolus Trafficking for Gamma-Catenin and p53 and Bulky-Ball-Like Nucleolus Assembly in Cancer Stem Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mammalian Skeletal Symmetry Relies on the TIMP Gene Family"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Approaches in Protease-Driven Diseases
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"The Role of ADAM17 and Its Substrates in Kidney Fibrosis
"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Protease Inhibition for the Treatment of Sepsis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"ADAM17 in the Control of Inflammation and Cancer"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
General Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure