Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Interplay Between Proteins and Membranes
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:20 pm
"Structural Basis of Calcium-Dependent Phospholipid Scrambling by TMEM16 Proteins"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"How Direct Protein-Lipid Interactions Shape the Conformational Landscape of Secondary Transporters"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The Flips and Flops of a Scramblase story: Insights into the Activation and Transport Mechanism of TMEM16 Proteins"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Linking Transport and Metabolism
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanics of Transition Metal Ion Transport by an Nramp Transporter"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structure of the Human LAT1-4F2hc Heteromeric Amino Acid Transporter Complex"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
"Structural Basis for pH-Dependent Retrieval of ER Proteins from the Golgi by the KDEL Receptor"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
"Outer Membrane Nutrient Processosomes in Dominant Human Gut Bacteria"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Translocation Mechanisms of Protein-Antibiotics"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Of Channels and Transporters: Potassium Uptake in Bacterial Survival"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
ABC Transporters in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Insight into Drug Transport and Small-Molecule Inhibition of Human ABCB1 and ABCG2"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Architectures of Lipid Transport Systems for the Bacterial Outer Membrane"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Conformational Space of a Heterodimeric ABC Exporter Under Turnover Conditions"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Mechanism of Allosteric Regulation of P-Glycoprotein"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ion Channels: From Atom to Animal
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Structural Titration of Human IP3 Receptors Reveals Mechanisms of Ligand-Dependent Gating"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Lipid Modulation of CNG Channels"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 10:55 am
"A Molecular Basis for Membrane Mediated Inhaled Anesthesia"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
"Architecture of the Proteolysis-Regulated Epithelial Sodium Channel"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Structural Basis of Dynamic TRP Channel Interaction with Lipids, Proteins and Cations"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Structure and Mechanism of P4-ATPase Lipid Flippases"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Folding in the Membrane
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Co-Translational Folding of Major Facilitator Superfamily Transporters"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Functional Mechanisms in Channels and Transporters"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Defining Membrane Boundaries of Proteins Using Electron Density Maps: The MemBlob Database and Server"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"How ATP Control of Pre-Protein Folding and the PMF Help Drive Protein Transport Across Membranes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Computational Design and Evolution of Function
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Simulating Alternating Access of Sodium Symporters"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structural and Mechanistic Diversity of Vitamin B12 Transporters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Structure of an Intermediate in the CLC Transport Cycle"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Personalized Structural Biology of the Voltage-Gated KCNQ1/KCNE1 Potassium Channel"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Evolution of Drug Export in the Small Multidrug Resistance Family"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Focusing the Computational Microscope on the Cell Envelopes of Gram-Negative Bacteria"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Technologies for Uncovering Mechanistic Insight
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Function and Pharmacology of Voltage-Gated Ion Channels"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Exploring a Multidrug Efflux Transporter by Deep Mutational Scanning"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"The Salipro System for Stabilization of Membrane Proteins"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Probing SERT Function with a Serotonin Biosensor"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Transporters and Channels Impacting Health and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"An Allosteric Oxyanion Binding Site Controls Na+/I- Symporter (NIS) Transport Stoichiometry"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Molecular Mechanisms of P2X3 Receptor Channel Activation and Modulation by Divalent Cation Bound ATP"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"How Toxins Modify Sodium Channels"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
"Nicotinic Receptor Reconstitution and Structure"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Import Mechanism of the Human Serotonin Transporter Revealed Through Mutational and Computational Energy Landscapes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Concepts in Membrane Transport Biology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Understanding Protein-Lipid Interactions in a Ciliary Membrane TRP Channel"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
"Cryo-EM Structures of MscS in a Lipid Bilayer and the Molecular Basis of 'Force from Lipids' Gating in Mechanosensitive Channels"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Role of Lipids in Dimer Formation of a Purine Transporter"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"How One Strong H-Bond Screws up a Transporter"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure