Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Ultrastructure and Macromolecular Assemblies in the Membrane
Discussion Leader: Nieng Yan (Shenzhen Medical Academy of Research and Translation (SMART) / Tsinghua University, China)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Simon Scheuring (Weill Cornell Medicine, United States)
"HS-AFM Discovers Conformational Transitions and Rare, Transient Conformational States"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Francesca Vallese (Columbia University, United States)
"AE1 Transporter and it's Role in the Human Erythrocyte Ankyrin-1 Complex"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Carol Robinson (oxford university, United Kingdom)
"From Recombinant Complexes in Detergent Micelles to Receptor Signaling Across Native Membranes - The Promises and Pitfalls of Native Mass Spectrometry"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
9:30 pm - 9:35 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Secondary Active Transporters
Discussion Leader: Nicolas Reyes (National Center of Scientific Research, France)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Gary Rudnick (Yale University, United States)
"Serotonin Transporter Conformation: Roles in Ion-Substrate Coupling and Beyond"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Lucy Forrest (National Institute of Neurological Disorders and Stroke, NIH, United States)
"Where Do All the Cations Go? The Intricate Ion Binding Configuration Assisting Serotonin Transport"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Liang Feng (Stanford University, United States)
"Molecular Mechanism of the Cation-Chloride Cotransporter"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Simon Newstead (University of Oxford, United Kingdom)
"Minding Your Ps & Qs: Exploring the Interface Between Transport and Trafficking in the Cell"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Lucy Forrest (National Institute of Neurological Disorders and Stroke, NIH, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interrogating Dynamic Transport
Discussion Leader: Claus Loland (University of Copenhagen, Denmark)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Katherine Henzler-Wildman (University of Wisconsin-Madison, United States)
"Activating Alternative Transport Modes in a Multidrug Resistance Efflux Pump to Confer Chemical Susceptibility"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Short Talk Selected from Poster Abstracts
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
Short Talk Selected from Poster Abstracts
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Olga Boudker (Weill Cornell Medicine, United States)
"Evolution of Ion Coupling Mechanisms in Glutamate Transporters"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane-Dependent Regulation of Transport
Discussion Leader: Lucie Delemotte (KTH Science for Life Laboratory, Sweden)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Joseph Mindell (NINDS, United States)
"Mechanism of ClC-7 Regulation by Lysosomal Phosphoinositides"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Sara Liin (Linköping University, Sweden)
"Modulation of the Kv7.1/KCNE1 Channel by Fatty Acids and Endocannabinoids"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Grace Brannigan (Rutgers University, United States)
"Specifically-Bound Lipids: Prediction, Detection, and Effect of the Surrounding Membrane"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jose Faraldo-Gomez (National Institutes of Health, United States)
"Lipid Bilayer Morphology as Driver of Membrane Protein Organization and Mechanism"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Design, Translocation and Folding of Membrane Transporters
Discussion Leader: Karen Fleming (Johns Hopkins University, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Peilong Lu (Westlake University, China)
"De Novo Design of Functional Transmembrane Proteins"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Nir Fluman (Weizmann Institute, Israel)
"Recognition of Misfolded Membrane Proteins in Bacteria"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
Zhen Yan (Westlake University, China)
"Structure of a TOC-TIC Supercomplex Spanning Two Chloroplast Envelope Membranes"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structure, Dynamics and Allostery of Ion Channels
Discussion Leader: Crina Nimigean (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Anna Stary-Weinzinger (University of Vienna, Department of Pharmaceutical Sciences, Austria)
"Probing Inward Rectifier K+ Channel Gating and Conductance Guided by Disease Mutations"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Cedric Govaerts (Universite Libre de Bruxelles, Belgium)
"Topological Reorganization Allosterically Regulates CFTR"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Ann McDermott (Columbia University, United States)
"Allostery in Ion channel Inactivation: NMR Studies"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Raimund Dutzler (University of Zurich, Switzerland)
"Activation and Inhibition of Volume Regulated Anion Channels of the LRRC8 Family"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanisms of ATP Coupled Transport
Discussion Leader: Robert Tampé (Goethe University Frankfurt, Germany)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Heather Pinkett (Northwestern University, United States)
"Selectivity and Assembly of ABC Importers"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Short Talk Selected from Poster Abstracts
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
Short Talk Selected from Poster Abstracts
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Bert Poolman (University of Groningen, The Netherlands)
"Synthetic Non-Equilibrium Vesicle Systems for Physicochemical Homeostasis and Membrane Transport"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The New World of Hybrid Transport
Discussion Leader: Renae Ryan (University of Sydney, Australia)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Show-Ling Shyng (Oregon Health and Science University, United States)
"Correlating Structure and Function in KATP Channel Isoforms"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Harley Kurata (University of Alberta, Canada)
"Surveying the Landscape of Unexpected Potassium Channel Regulators"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
Rachel North (Stockholm University, Sweden)
"Structure and Mechanism of a Tripartite ATP-Independent Periplasmic TRAP Transporter"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jianping Wu (Westlake University, China)
"Catspermasome: The Matrimony of CatSper Channel and SLC06C1"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Physiological Connections to Transport Mechanisms
Discussion Leader: Rajan Sah (Washington University in St. Louis, United States)
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:25 pm
Thomas Jentsch (Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) , Germany)
"ASOR/Tmem206: A Previously Enigmatic Acid-Activated Cl Channel in Endocytic Compartments"
4:25 pm - 4:35 pm
Discussion
4:35 pm - 4:50 pm
Short Talk Selected from Poster Abstracts
4:50 pm - 5:00 pm
Discussion
5:00 pm - 5:20 pm
Robert Edwards (University of California, San Francisco, United States)
"Allosteric Regulation of Vesicular Glutamate Transport"
5:20 pm - 5:30 pm
Discussion
5:30 pm - 5:50 pm
Rajini Rao (Johns Hopkins University, United States)
"Crosstalk Between Organellar Calcium Homeostasis"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 7:30 pm
Poster Session
7:30 pm - 8:30 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure