Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Paradigm-Shifting Discoveries in Membrane Transport
7:40 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:25 pm
"How Proteins Cross Membranes"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"E. coli LetA Defines a Structurally Distinct Transporter Family Involved in Lipid Trafficking"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Protein Translocation in Unconventional Release of Leaderless Secretory Proteins"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"A Comparative Perspective on Proposed Mechanisms of Proton Translocation in Complex I and its Relatives"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diverse Gating Mechanisms of Ion Channels
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"A Synthetic Potassium Channel Reduces Oxidative Stress via Cellular Adaptronics"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Structural Basis of Subtype-Specific Pharmacology in the rho1 GABA(A) Receptor"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Mechanically-Induced Gating in OSCA/TMEM63 Channels"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Gating and Regulation of SWELL1 Volume-Regulated Anion Channel"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Diverse Gating Mechanisms of MscS-like Ion Channels"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Pentameric Chloride Channel BEST1 is Activated by Extracellular GABA"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Online Membrane Protein Purification and Cryo-EM Sample Preparation at the Nanoscale"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Secondary Active Transporters in Health and Disease
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Determinants of Substrate Selectivity in Nramp-Family Transition Metal Transporters"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Substrate Recognition by the Amino Acid Transporter SNAT2 Revealed by Cryo-EM"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"A (male) Na+ /H+ Exchanger with Potential"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"The Molecular Mechanisms Underlying Cellular Uptake of Vitamin A"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanism of Primary Active Transport
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Conformational Dynamics of ABC Transporters in vitro and in silico "
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Cytomegalovirus-Arrested Peptide-Loading Complex Reveals Transporter Inhibition and Chaperone Sequestration"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"An Evolutionary, Structural and Mechanistic Link Between Primary and Secondary Transporters"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Elucidating the Structural Dynamics of the Nickel Transporter Ynt and its Implications for Urease Activity in Proteus Mirabilis "
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"CFTR Function, Pathology and Pharmacology at Single-Molecule Resolution"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Lipid-Dependence of Polyamine Transport"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Yeast Lipid Flippase Drs2/Cdc50 Transports Multiple Negatively Charged Phospholipids Besides Phosphatidylserine"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Detergent-Free Reconstitution of Transmembrane Proteins in Giant Liposomes of Complex Curvature by the Synthetic Membrane Transfer (SMT)"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interplay Between Lipids and Membrane Proteins
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Dietary Fatty Acids Modulate the Function of PIEZO Mechanosensitive Ion Channels"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"LYCHOS is a Human Hybrid of a Plant-Like PIN Transporter and a GPCR"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Interactions Between TTYH2 and ApoE Facilitate Endosomal Lipid Transfer"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Molecular Basis of Neurosteroid and Anticonvulsant Regulation of TRPM3"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diversity in Membrane Transport
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Membrane Protein Quality Control at the ER"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"ATP Transport into the Endoplasmic Reticulum"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Structural Mechanisms of Olfaction in Insects"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"The Structural Basis of Carnitine Transport"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Mechanisms of Plant Hormone Transport"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Structural and Functional Characterization of Two Members of the SLC10 Family"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Structural and Functional Diversity of Channelrhodopsins"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Drugs on Membrane Transport Targets
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Modulation of Pentameric Ligand-Gated Channel Function"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Computer Driven Structure Based Ligand Discovery Targeting Membrane Proteins: Advances and Challenges"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Small-Molecule Modulation of the P2X7 Receptor Revealed by Cryo-EM"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Mechanism and Energetics of AE1 Elevator Transport Cycle in Red Blood Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Physiological Connections to Transport Mechanisms
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Solute Carriers in Brain Metabolism"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Mechanosensitive Channels Underlying Hearing and Balance also Function as Regulable Lipid Scramblases"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"An Unanticipated Species Difference in Function"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Transport Mechanisms in the Golgi Membrane"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Allosteric Modulation of Neurotransmitter Transporters: A Structural and Functional Perspective"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Molecular Determinants Governing a Channelopathy-Induced Ataxia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Phenotypic Spectrum of CLCN6-Associated Neurological Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Conformational Dynamics in Membrane Transporters and Channels
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"NMDA Receptors: Dynamic Control of Ca2+ Permeability"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Ligand Dependent Conformational Changes of Membrane Proteins"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Physical Coupling of Transport and Signaling in Antimicrobial Resistance Mechanisms"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Conserved and Unique: Mapping Protein Dynamics to Rethink Drug Discovery"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure