| Sunday |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: Metal-Based Drugs and Cellular Redox Biochemistry |
| Discussion Leaders: Katherine Franz (Duke University, USA) and Nils Metzler-Nolte (Ruhr University Bochum, Germany) |
| 7:40 pm - 7:55 pm | Opening Remarks |
| 7:55 pm - 8:30 pm | Ruma Banerjee (University of Michigan, USA)
"Redox Enzymology of H2S Metabolism and
Signaling" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:15 pm | Thomas O'Halloran (Northwestern University, USA)
"Bioinorganic Drug Discovery: Metal-Based Drugs and Targets in the Treatment of Metastatic Cancer" |
| 9:15 pm - 9:30 pm | Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Harnessing Metal Trafficking Pathways
for Antimicrobial Drug Development |
| Discussion Leader: Elizabeth Nolan (Massachusetts Institute of Technology, USA) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:35 am | Celia Goulding (University of California, Irvine, USA)
"Targeting Heme/Iron Uptake Pathways in Mycobacterium tuberculosis" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Amanda Oglesby-Sherrouse (University of Maryland, Baltimore, USA)
"Critical Role of Iron Regulatory Pathways in Pseudomonas aeruginosa Virulence" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Jeffrey Henderson (Washington University School of Medicine, USA)
"Metals and Metabolomes
in Gram Negative Bacterial Pathogenesis" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Timothy Wencewicz (Washington University in St. Louis, USA)
"Siderophore Chemistry in Pathogenic Acinetobacter baumannii" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Angela Casini (Cardiff University, United Kingdom) |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Targeting Cancer and Infection with Photodynamic
Compounds |
| Discussion Leader: Edith (Phoebe) Glazer (University of Kentucky, USA) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 8:05 pm | Gilles Gasser (University of Zurich, Switzerland)
"Metal Complexes as Phototoxic Anticancer Agents" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Sherri McFarland (Acadia University, Canada)
"Coordination Chemistry and Photodynamic Therapy" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:25 pm | Adah Almutairi (University of California, San Diego, USA)
"Light Stimulation to Direct Drug-Delivering Nanoparticles" |
| 9:25 pm - 9:30 pm | Discussion |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Emerging Analytical Methods (or, What Happens to My Metallodrug In Vivo?) |
| Discussion Leader: Angela Casini (Cardiff University, United Kingdom) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:35 am | Fabio Arnesano (University of Bari Aldo Moro, Italy)
"Solution and In-Cell NMR Methods to Monitor Proteins Interacting with Inorganic Materials" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Hugh Harris (The University of Adelaide, Australia)
"XRF and XAS Combined Yield Insight into the Biological Fate of Metallodrugs" |
| 10:15 am - 10:25 am | Discussion |
| 10:25 am - 10:55 am | Coffee Break |
| 10:55 am - 11:25 am | Christian Hartinger (University of Auckland, New Zealand)
"Bioanalytical Studies to Elucidate Tumor-Inhibiting Action of Metal Complexes" |
| 11:25 am - 11:40 am | Discussion |
| 11:40 am - 11:55 am | Chady Stephan (PerkinElmer, Canada)
"Single Cell ICP-MS: Understanding the Uptake Mechanism of Cisplatin by Cancerous Cells" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | Poster Previews |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Inorganic Chemistry and Cellular Redox
Regulation |
| Discussion Leader: Peter Sadler (University of Warwick, United Kingdom) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 8:05 pm | Elisa Tomat (University of Arizona, USA)
"Redox-Directed Strategies Targeting the Iron Metabolism of Cancer Cells" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Milos Filipovic (IBGC - Institut de Biochimie et Genetique Cellulaires / CNRS, France)
"Intracellular H2S Signalling and Cross-Talk with Metal Centers" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Alexander M. Cruickshank Lecture: Christopher Chang (University of California, Berkeley, USA)
"Chemical Probes for Studying Reactive Oxygen, Sulfur, and Carbon Species in Biology" |
| 9:20 pm - 9:30 pm | Discussion |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Creative
Approaches in Imaging Agent Design |
| Discussion Leader: Matthew Allen (Wayne State University, USA) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:35 am | Elizabeth New (University of Sydney, Australia)
"Molecular Imaging Tools to Study the Interactions of Transition Metals with Cells" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:20 am | Jens Hasserodt (École Normale Supérieure de Lyon, France)
"Translating the Activity of an Enzyme Analyte into Beating the Chelate Effect" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Clotilde Policar (Ecole Normale Superieure de Paris, France)
"Re(CO) Probes as Multimodal Probes for Imaging: Fluorescence and IR-Imaging" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Thomas Meade (Northwestern University, USA)
"Advances in Bio-Activated and Targeted MR Imaging Probes: Are We There Yet?" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Compound to Clinic: Not Lost in Translation |
| Discussion Leader: Lisa Jarvis (Chemical & Engineering News, USA) |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader |
| 7:40 pm - 8:00 pm | Chris Orvig (University of British Columbia, Canada)
"Antidiabetic Vanadium Compounds: From Concept to Clinic" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Paul Donnelly (University of Melbourne, Australia)
"The First-Time-in-Human Trial of 64CuMeCOSar-octreotate (CuSarTATE) for Imaging Neuroendocrine Tumours" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Amir Nashat (Polaris Partners, USA)
"How to Start a Company with Academic Research" |
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:30 pm | General Discussion |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Late-Breaking Topics |
| Discussion Leader: Kenneth Kam-Wing Lo (City University of Hong Kong, Hong Kong SAR China) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:30 am | Jun-Long Zhang (Peking University, China)
"Design of NIR Emissive Metal Complexes as Biological Probes in Cell Imaging" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Daniela Buccella (New York University, USA)
"New Chemical Tools and Strategies for the Study of Intracellular Magnesium Mobilization: Visualizing Mg2+ Fluctuations in Apoptosis" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:20 am | Guangyu Zhu (City University of Hong Kong, Hong Kong SAR China)
"Monochalcoplatin, a Transporter Favorable and Highly Cytotoxic Pt(IV) Anticancer Prodrug" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:05 am | Coffee Break |
| 11:05 am - 11:20 am | Ben-Zhan Zhu (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, China)
"Redirecting Ru(II)-DPPZ Complex into Nucleus for Enantioselective Live-Cell DNA-Imaging and Photosensitizing via Simple 'Yin-Yang' Ion-Pairing" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Ashley Bush (Florey Institute of Neuroscience and Mental Health, Australia)
"Iron and Ferroptosis in Aging and Brain Disease" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | Poster Previews |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Neurodegeneration: Biology, Pathology, Chemistry and
Collaboration |
| Discussion Leader: Paul Donnelly (University of Melbourne, Australia) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 8:05 pm | Jeffrey Liddell (University of Melbourne, Australia)
"The Molecular Processes Underlying the Broad Neuroprotective Action of Metal-Complexes" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Peter Crouch (University of Melbourne, Australia)
"Therapeutic Outcomes for the Metallo-Complex Cu(atsm) in Animal Models of Motor Neuron Disease Provide New Insight to the Mechanisms of Pathogenesis" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Blaine Roberts (Florey Institute of Neuroscience and Mental Health, Australia)
"Application of Metalloproteomics to Define the Role of Metalloproteins in Neurodegenerative Diseases" |
| 9:20 pm - 9:30 pm | Discussion |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
