Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Metal-Based Drugs and Cellular Redox Biochemistry |
| Discussion Leaders: Katherine Franz (Duke University, USA) and Nils Metzler-Nolte (Ruhr University Bochum, Germany) |
7:40 pm - 7:55 pm | Opening Remarks |
7:55 pm - 8:30 pm | Ruma Banerjee (University of Michigan, USA) "Redox Enzymology of H2S Metabolism and
Signaling" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Thomas O'Halloran (Northwestern University, USA) "Bioinorganic Drug Discovery: Metal-Based Drugs and Targets in the Treatment of Metastatic Cancer" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Harnessing Metal Trafficking Pathways
for Antimicrobial Drug Development |
| Discussion Leader: Elizabeth Nolan (Massachusetts Institute of Technology, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | Celia Goulding (University of California, Irvine, USA) "Targeting Heme/Iron Uptake Pathways in Mycobacterium tuberculosis" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Amanda Oglesby-Sherrouse (University of Maryland, Baltimore, USA) "Critical Role of Iron Regulatory Pathways in Pseudomonas aeruginosa Virulence" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Jeffrey Henderson (Washington University School of Medicine, USA) "Metals and Metabolomes
in Gram Negative Bacterial Pathogenesis" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Timothy Wencewicz (Washington University in St. Louis, USA) "Siderophore Chemistry in Pathogenic Acinetobacter baumannii" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Targeting Cancer and Infection with Photodynamic
Compounds |
| Discussion Leader: Edith (Phoebe) Glazer (University of Kentucky, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:05 pm | Gilles Gasser (University of Zurich, Switzerland) "Metal Complexes as Phototoxic Anticancer Agents" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Sherri McFarland (Acadia University, Canada) "Coordination Chemistry and Photodynamic Therapy" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:25 pm | Adah Almutairi (University of California, San Diego, USA) "Light Stimulation to Direct Drug-Delivering Nanoparticles" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Emerging Analytical Methods (or, What Happens to My Metallodrug In Vivo?) |
| Discussion Leader: Angela Casini (Cardiff University, United Kingdom) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | Fabio Arnesano (University of Bari Aldo Moro, Italy) "Solution and In-Cell NMR Methods to Monitor Proteins Interacting with Inorganic Materials" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Hugh Harris (The University of Adelaide, Australia) "XRF and XAS Combined Yield Insight into the Biological Fate of Metallodrugs" |
10:15 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:25 am | Christian Hartinger (University of Auckland, New Zealand) "Bioanalytical Studies to Elucidate Tumor-Inhibiting Action of Metal Complexes" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Chady Stephan (PerkinElmer, Canada) "Single Cell ICP-MS: Understanding the Uptake Mechanism of Cisplatin by Cancerous Cells" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inorganic Chemistry and Cellular Redox
Regulation |
| Discussion Leader: Peter Sadler (University of Warwick, United Kingdom) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:05 pm | Elisa Tomat (University of Arizona, USA) "Redox-Directed Strategies Targeting the Iron Metabolism of Cancer Cells" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Milos Filipovic (IBGC - Institut de Biochimie et Genetique Cellulaires / CNRS, France) "Intracellular H2S Signalling and Cross-Talk with Metal Centers" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Alexander M. Cruickshank Lecture: Christopher Chang (University of California, Berkeley, USA) "Chemical Probes for Studying Reactive Oxygen, Sulfur, and Carbon Species in Biology" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Creative
Approaches in Imaging Agent Design |
| Discussion Leader: Matthew Allen (Wayne State University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | Elizabeth New (University of Sydney, Australia) "Molecular Imaging Tools to Study the Interactions of Transition Metals with Cells" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Jens Hasserodt (École Normale Supérieure de Lyon, France) "Translating the Activity of an Enzyme Analyte into Beating the Chelate Effect" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Clotilde Policar (Ecole Normale Superieure de Paris, France) "Re(CO) Probes as Multimodal Probes for Imaging: Fluorescence and IR-Imaging" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Thomas Meade (Northwestern University, USA) "Advances in Bio-Activated and Targeted MR Imaging Probes: Are We There Yet?" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Compound to Clinic: Not Lost in Translation |
| Discussion Leader: Lisa Jarvis (Chemical & Engineering News, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Chris Orvig (University of British Columbia, Canada) "Antidiabetic Vanadium Compounds: From Concept to Clinic" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Paul Donnelly (University of Melbourne, Australia) "The First-Time-in-Human Trial of 64CuMeCOSar-octreotate (CuSarTATE) for Imaging Neuroendocrine Tumours" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Amir Nashat (Polaris Partners, USA) "How to Start a Company with Academic Research" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Late-Breaking Topics |
| Discussion Leader: Kenneth Kam-Wing Lo (City University of Hong Kong, Hong Kong SAR China) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Jun-Long Zhang (Peking University, China) "Design of NIR Emissive Metal Complexes as Biological Probes in Cell Imaging" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Daniela Buccella (New York University, USA) "New Chemical Tools and Strategies for the Study of Intracellular Magnesium Mobilization: Visualizing Mg2+ Fluctuations in Apoptosis" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:20 am | Guangyu Zhu (City University of Hong Kong, Hong Kong SAR China) "Monochalcoplatin, a Transporter Favorable and Highly Cytotoxic Pt(IV) Anticancer Prodrug" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:05 am | Coffee Break |
11:05 am - 11:20 am | Ben-Zhan Zhu (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, China) "Redirecting Ru(II)-DPPZ Complex into Nucleus for Enantioselective Live-Cell DNA-Imaging and Photosensitizing via Simple 'Yin-Yang' Ion-Pairing" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Ashley Bush (Florey Institute of Neuroscience and Mental Health, Australia) "Iron and Ferroptosis in Aging and Brain Disease" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Neurodegeneration: Biology, Pathology, Chemistry and
Collaboration |
| Discussion Leader: Paul Donnelly (University of Melbourne, Australia) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:05 pm | Jeffrey Liddell (University of Melbourne, Australia) "The Molecular Processes Underlying the Broad Neuroprotective Action of Metal-Complexes" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Peter Crouch (University of Melbourne, Australia) "Therapeutic Outcomes for the Metallo-Complex Cu(atsm) in Animal Models of Motor Neuron Disease Provide New Insight to the Mechanisms of Pathogenesis" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Blaine Roberts (Florey Institute of Neuroscience and Mental Health, Australia) "Application of Metalloproteomics to Define the Role of Metalloproteins in Neurodegenerative Diseases" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |