Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Metal Ion Regulations/Dysregulation in Human Disease
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Mechanisms of FDX1-Regulated Cuproptosis"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Developing a Molecular Bioinorganic Profile of Extracellular Fluids for Biomarker Discovery"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Activity-Based Sensing and Proteomics Platforms to Decode and Drug Transition Metal Signaling"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Opportunities and Challenges for the Advancement of Metal-Based Drugs in the Clinic
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"From Inorganic Chemical Biology to Drug Development Against Emerging Infectious Diseases"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"NOVO-111: Preclinical and Clinical Development of A Novel Metallated Macrocycle Drug Conjugate"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Padeliporfin - A Pd Centered Bacteriochlorophyll That Drives Novel Therapy of Solid Tumors - From Bench to Clinic"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Copper Depletion as A Therapeutic Strategy to Prevent Metastases in Breast Cancer"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Update on the Clinical Progress of TLD1433 (Ruvidar)"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unconventional Modes of Action for Metal-Based Drugs
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Modulating the Chemical Reactivity of Gold Complexes in Living Systems: From Concept to Biomedical Applications"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Ligand-Directed Metal-Mediated Protein Targeting in Drug Discovery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Activation of Metal-Based Drugs
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Ir/Ru/Os Based Photosensitizers for Cancer Phototherapy and Antimicrobial Photodynamic Therapy"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"External Control Over Internal Metals"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Understanding and Harnessing Intracellular Activation of Platinum(IV) Prodrug Complexes"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Development of Metallo-Photoantibiotics for Potential Antibacterial, Antibiofilm, and Wound Healing Applications"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Modulation Amyloid Beta Aggregation by Photoactive Metal Complexes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Chemical (Bioinorganic) Strategies to Study Multiple Facets in Dementia"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Metal-Containing Multimodal Imaging Agents: Applications to Neuroimaging in Alzheimer’s Disease"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Ruthenium Complexes as Modulators of Amyloid-β Aggregation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Optimizing Drug Delivery Strategies
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Design of Dual Targeting Pt(IV) Complexes, Screening in 3D Spheroids and Strategic Delivery in Animal Cancer Models"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Sweet Bullets: Hijacking Sugar Transporters for Targeted Metallodrug Delivery"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Beyond Drug Delivery: Self-Assembled Systems for Multimodal Therapeutics"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Seeing is Believing: But Just What are We Really Seeing"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Precision Supramolecular Glycan Assemblies for Probing Multivalent Protein Recognition"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metal-Based Compounds to Treat Neglected Tropical Diseases
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Metallodrugs are Promising Candidates for the Treatment of Parasitic Diseases"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Do We Have to Think About p-Block Elements Differently? Bringing Insight from Fundamental Main-Group Chemistry to Medicinal Inorganic Chemistry"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Short Talk Selected from Poster Abstracts
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Imaging Modalities through Inorganic Chemistry
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"New Tools for Visualizing Metal Ions in Live Cells: Optical and Vibrational Molecular Probes"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Metal Complexes for Diagnostics and for Triggering Unexpected Biological Processes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Systematic Approaches to Metal-based Probe Development Across Modalities"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"The All-Spin Zone: Coupling, Environment, and Opportunity"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"19F Magnetic Resonance Strategies for Molecular Imaging of Redox, pH, and Beyond"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Radionuclide-Based Therapeutics and Diagnostics
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Antibody-Based Radionuclides for Cancer Imaging and Therapy"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Elementally Matched Radionuclides for Theranostic Applications"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Radiometals - Rethinking Their Use in A Golden Age"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure