Sunday |
2:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Synapse Formation and Synaptic Plasticity |
| Discussion Leader: Rafael Fernandez-Chacon (Instituto de Biomedicina de Sevilla (IBiS) / Universidad de Sevilla / CSIC / CIBERNED, Spain) |
7:40 pm - 8:25 pm | Thomas Sudhof (Stanford University, USA) "Molecular Mechanisms of Synapse Formation and Restructuring" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Pascal Kaeser (Harvard Medical School, USA) "Assembly and Function of the Presynaptic Active Zone" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Juergen Knoblich (Institute of Molecular Biotechnology, Austria) "Modeling Human Brain Development and Disease in 3D Organoid Culture" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Synapse Formation and Synaptic Plasticity (continued) / Dendritic Development |
| Discussion Leader: Mingjie Zhang (Hong Kong University of Science and Technology, Hong Kong SAR China) |
9:00 am - 9:25 am | Jun Ding (Stanford University School of Medicine, USA) "Mixed Signals - Modulation of Synaptic Plasticity by Midbrain Dopamine Neurons" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Xiang Yu (Institute of Neuroscience, Chinese Academy of Sciences, China) "An Inducing Role for Pre-Synaptic Cadherin/Catenin Complex in Synaptogenesis and Spinogenesis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Lily Jan (University of California, San Francisco, USA) "Unexpected Channel Functions in the Nervous System" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:25 am | Yuh-Nung Jan (University of California, San Francisco, USA) "Dendrite Morphogenesis: From Form to
Function" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Tomomi Shimogori (RIKEN Brain Science Institute, Japan) "Rho Activity of BTBD3-PlexinA4 Complex Induced by Neuronal Activity for Selective Dendrite Removal" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Michael Lin (Stanford University, USA) "Two-Photon Imaging of Brain Activity with Improved ASAP-Family Voltage Indicators" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Yingxi Lin (Massachusetts Institute of Technology, USA) "A Robust Activity Marking (RAM) System for Exploring Active Neuronal Ensembles" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Neural Stem Cells and Neural Lineage Development |
| Discussion Leader: John Ngai (University of California, Berkeley, USA) |
7:30 pm - 7:55 pm | Simon Hippenmeyer (Institute of Science and Technology Austria, Austria) "Programmed Deterministic Genesis of Neurons and Glia in the Neocortex" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Yukiko Gotoh (University of Tokyo, Japan) "Embryonic vs Adult Neural Stem Cells" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Hongjun Song (Johns Hopkins University, USA) "Single Cell Analysis of Neurogenesis in the Mammalian Brain" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Zhiheng Xu (Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, China) "Zika Virus Infection Leads to Microcephaly" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Circuits-Based Behavioral Study |
| Discussion Leader: Yuh-Nung Jan (University of California, San Francisco, USA) |
9:00 am - 9:25 am | Qiufu Ma (Harvard Medical School, USA) "Spinal Circuits Transmitting and Gating Mechanical Pain" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Xiaoke Chen (Stanford University, USA) "Brain Circuits Mediating Negative Emotions" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Yi Zuo (University of California, Santa Cruz, USA) "Stress Induces Synaptic and Circuit Reorganization in the Mouse Cerebral Cortex" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Nirao Shah (University of California, San Francisco, USA) "Sensory and Hormonal Control of Social Interactions" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Peng Cao (Institute of Biophysics, Chinese Academy of Sciences, China) "A Brain Circuit to Trigger Fear Responses: Its Identification, Characterization and Preliminary Translational Research" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Wei Wei (The University of Chicago, USA) "Distinct Neural Mechanisms Underlying the On and Off Pathways of Direction Selectivity in the Retina" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Michael Hart (Howard Hughes Medical Institute / Columbia University, USA) "Experience-Dependent GABAergic Structural Plasticity in Male C. Elegans" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
2:00 pm - 4:00 pm | Poster Session |
4:00 pm - 6:00 pm | Epigenetics and Behavioral Plasticity |
| Discussion Leader: Lin Mei (Augusta University, USA) |
4:00 pm - 4:25 pm | Azad Bonni (Washington University School of Medicine in St. Louis, USA) "Epigenetic Regulation of Neuronal Connectivity in the Brain" |
4:25 pm - 4:30 pm | Discussion |
4:30 pm - 4:55 pm | Peng Jin (Emory University, USA) "Active DNA Modifications in Neurodevelopment and Diseases" |
4:55 pm - 5:00 pm | Discussion |
5:00 pm - 5:15 pm | Hao Wu (University of Pennsylvania, USA) "Neuronal DNA Methylome: How Dynamic Is It?" |
5:15 pm - 5:20 pm | Discussion |
5:20 pm - 5:35 pm | Jiang Wu (University of Texas Southwestern Medical Center, USA) "Specific Functions of an Autism-Associated Chromatin Remodeling Complex in Neuron Development" |
5:35 pm - 5:40 pm | Discussion |
5:40 pm - 5:55 pm | Xiaohong Xu (Institute of Neuroscience, Chinese Academy of Sciences, China) "Reciprocal Antagonism Between Hunger and Maternal Care" |
5:55 pm - 6:00 pm | Discussion |
6:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Disease Modeling from Yeast to Non-Human Primate |
| Discussion Leader: Louis Reichardt (Simons Foundation, USA) |
9:00 am - 9:25 am | Aaron Gitler (Stanford University, USA) "Expanding Mechanisms and Therapeutic Targets for Neurodegenerative Diseases" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Zilong Qiu (Institute of Neuroscience, Chinese Academy of Sciences, China) "The Non-Human Primate Model for Brain Disorders — What Can We Learn from the Monkey?" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Weizhi Ji (The Yunnan Key Laboratory of Primate Biomedical Research, China) "Modeling Rett Syndrome Using Non-Human Primate via Gene-Editing" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Guo-Li Ming (Johns Hopkins University, USA) "Using Human iPSCs for Modeling Neural Developmental Disorders" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Susan Bookheimer (University of California, Los Angeles, USA) "Translational Approaches to Understanding Developmental Disabilities: Linking Genes, Brain and Behavior in Autism Spectrum Disorders" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Hyunsoo Je (Duke-NUS Graduate Medical School, Singapore) "Synaptic Dysfunction in Autism" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Application of Stem Cells in Disease Modeling and Neural Repair |
| Discussion Leader: Yi Sun (University of California, Los Angeles, USA) |
7:30 pm - 7:55 pm | Gong Chen (Pennsylvania State University, USA) "In Vivo Reprogramming: Reversing Glial Scar for Brain Repair" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Xiaoguang Li (Beihang University, China) "NT-3-Chitosan Elicit Robust Endogenous Neural Stem Cell Activation and Neural Repair After a Severe Case of Spinal Cord Injury" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Kinichi Nakashima (Kyushu University, Japan) "Neural Stem Cell Regulation and Its Therapeutic Application to Spinal Cord Injury" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Keqiang Ye (Emory University, USA) "Delta-Secretase in Alzheimer's Disease and Its Drug Discovery" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Advancements in Understanding Neurodegeneration and Repair |
| Discussion Leader: Wen-Cheng Xiong (Georgia Regents University, USA) |
9:00 am - 9:25 am | Nancy Ip (The Hong Kong University of Science and Technology, Hong Kong SAR China) "Modulation of Innate Immunity in Alzheimer's Disease" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Yimin Zou (University of California, San Diego, USA) "Recovery of Cortical Motor Control After Spinal Cord Injury" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Bai Lu (Tsinghua University School of Medicine, China) "Synaptic Repair Strategy for Neurodegenerative Diseases" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:15 am | Jianzhi Wang (Tongji Medical College, Huazhong University of Science and Technology, China) "Opposite Monosynaptic Scaling of BLP-vCA1 Inputs Governs Hopefulness- and Helplessness-Modulated Spatial Learning and Memory" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Weihong Ge (University of California, Los Angeles, USA) "Transciptome Analyses with WGCNA Reveal Three Key Elements to the Success of Neural Repair in CNS" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Kai Liu (Hong Kong University of Science and Technology, Hong Kong SAR China) "Enhancing Neuronal Activity by Melanopsin/GPCR Signaling Promotes Axon Regeneration in the Adult CNS" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Louis Reichardt (Simons Foundation, USA) "Autism: Scientific Efforts to Overcome Barriers that Limit Understanding, Diagnosis and Treatment" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Connectome, Brain Imaging, and Single Cell Transcriptome Analyses |
| Discussion Leader: Michael Lin (Stanford University, USA) |
4:00 pm - 4:25 pm | Hongwei Dong (University of Southern California, USA) "Assembling Global Neural Networks of the Mouse Brain" |
4:25 pm - 4:30 pm | Discussion |
4:30 pm - 4:55 pm | Jin Hyung Lee (Stanford University, USA) "Investigation of Global Brain Circuit Mechanisms with Cell Type Specificity" |
4:55 pm - 5:00 pm | Discussion |
5:00 pm - 5:25 pm | Zhiping Pang (Robert Wood Johnson Medical School, Rutgers University, USA) "Using Human Neurons to Study Addiction Associated Gene Variants" |
5:25 pm - 5:30 pm | Discussion |
5:30 pm - 5:45 pm | Russell Fletcher (University of California, Berkeley, USA) "Cell Fate Decisions and Lineage Trajectories in the Olfactory Stem Cell Niche" |
5:45 pm - 5:50 pm | Discussion |
5:50 pm - 6:00 pm | Closing Remarks |
6:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |