Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Regulation and Function of Multi-Drug Efflux Systems in Health and Disease
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Altered Hepatic Efflux Transporters in Liver Disease: Implications for Precision Medicine"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Assembly and Mechanism of Tripartite Drug Efflux Machines"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Insights into Structure-Function of Multi-Drug Efflux Pumps
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Functional Dynamics of P-Glycoprotein"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Polyspecificity and Transport Mechanism of RND Efflux Pumps: What Can We Learn from In Silico Studies?"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Structural Insights into Mammalian ABC Transporters from Cryo-EM and Crystallography"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structural and Molecular Dynamical Approaches to Understand MFS Type Multidrug Resistance Transporters"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"An Integrated Approach to Antibiotic Efflux and Its Inhibition in Gram-Negative Bacteria"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Structural Basis of Drug Transport and Small Molecule Inhibition in Human ABCG2 and ABCB1"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Efflux Transporters at Sanctuary Sites
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Chronic Morphine and Pain Alter Trafficking of P-Glycoprotein at the BBB/NVU"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Plasmodium falciparum Transporters that Interact with Diverse Antimalarials: Resistance Mediators as Drug Targets"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"Claramine A1, a New Efficient Antibacterial Polyaminosterol Family Member: A Mechanistic Rational Investigation"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:40 pm
"ABC Transporters at the Blood-Brain Barrier and Their Role in Limiting Access of Drugs to the CNS"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"A Novel DiOC3 -Based Real-Time Efflux Assay Demonstrates Inhibition of the S. aureus NorA Efflux Pump by Essential Oils from Moroccan Thymus sp."
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Role of Influx and Efflux Pumps in the Balance Between Drug Access and Toxicity
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Placental Efflux Transporters in Health and Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Molecular Structures and Evolution of Efflux Pumps Used by Bacteria to Evade Host Strategies for Their Elimination"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Multidrug Transporters at the Blood-Brain and Blood-CSF Barriers and Prediction of CNS Penetration"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Multidrug Efflux Pumps and Antibiotic Resistance"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Role of Lipid Environment on Hepatocellular (Drug) Transporter Activity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Understanding Translocation for the Development of Novel Drugs"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interplay Between the Microbiome and Multidrug Resistance
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"The ABC's of Microbial Regulation of Lipid Immuno-Modulators in Intestinal Health and Disease"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Regulation of Intestinal Drug Influx and Efflux by Human Gut Bacterial Metabolism"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance in the Gut Microbiota"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Structure of a Tripartite RND Efflux System in Lipid Membrane"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Roles for Efflux Pumps in Cell Signaling in Health and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genetic Diversity and Emerging Role in Drug Resistance of norA , a Main Efflux Pump of Staphylococcus aureus "
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"From Macromolecular Complexes to Personalized Medicine in Cystic Fibrosis: A Role for MRP4?"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Inhibition of Patched Drug Efflux Increases Vemurafenib Efficacy Against Melanoma Cells"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Role of ABCG2 in Uric Acid Homeostasis and Hyperuricemia and Gout"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"ABC Transporters in Cancer"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Towards Single-Molecule Characterisation of the Alternating Access Mechanism in MdfA"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Crystal and Cryo-EM Structures of the Tripartite-ABC Transporter MacB"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Learning from Drug Resistance Across Diseases
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"MicroRNAs Modulate Transporter Expression and Drug Response"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Variability in ABC Transporter Expression in Cancer Drug Resistance"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Membrane-Associated Mechanisms of Resistance in Gram-Negative Bacteria: New Methods to Analyze the Antibiotic Translocation"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Reversing Antibiotic Resistance with Efflux Pump Inhibitors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
New Approaches for Understanding the Function of Membrane Transporters
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"EPR, X-Ray and MD Simulations Unveil the Mechanism of the Conformational Transition in a Heterodimeric ABC Exporter"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Studying Renal Drug Transport and Its Interactions in 4-Dimensions"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Understanding Structure and Function of Promiscuous RND-Type Multidrug Efflux Systems"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Structure of MRP4 in a Lipid Nanodisc"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Reconstitution of Tripartite Efflux Pumps: From Minimal Systems to the Complexity of the Bacterial Membrane"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Energetics of ABC Exporters: A Changing Perspective on the Power to Change"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"New Insights into the Opening Mechanism of the OprM-MexAB Efflux Pump from Pseudomonas aeruginosa "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Contribution of Membrane Transporters to Precision Medicine and Drug Development
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Drug Trafficking: Is It What We Think?"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Efflux Transporters and Their Roles in Precision Medicine: Focusing on Kidney Transporters"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Drosophila melanogaster as a Pre-Clinical Test Model for Human Drug Membrane Transporters"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Evidence for Second-Site Suppressor Mutations in Human P-Glycoprotein"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure