Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Natural Products in the Service of Human Health
7:40 pm - 8:20 pm
"The Economics of Antibacterial Drug Development, Getting Biotech and Big Pharma Back in the Game"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Recent Advances in Natural Product and Bioactive Compound Synthesis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Discovery and Chemistry of New Secondary Metabolites
9:00 am - 9:30 am
"Mining Microbial Metabolome: A New Paradigm in Natural Products Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Utilization of Hydrophobic TAGs for Synthesis of Unique Peptide Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Insights from Screening 10,000 Marine Natural Products Extracts for Antimicrobial Activity"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Microbial Biosynthesis of Complex Plant-Derived Natural Products"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Constructing Architecturally Complex Molecules
7:30 pm - 8:00 pm
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Complex Alkaloid Total Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Conformation-Activity Relationships in Complex Natural Products Inspired by Biosynthesis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Methods Development in Pursuit of Bioactive Molecules
9:00 am - 9:30 am
"Oxygen Driven Fragment Coupling by Activation of C-H, N-H and O-H Bonds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"NRPS-Engineering for the Modification and De Novo Generation of Peptide Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"The Sweet Taste of Replacing Hydrogen with Glucose: Catalytic Synergy for Chemoselective Enzymatic Reductions"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Deploying Natural Design Principles for Cell-Based Factories"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Synthetic Biology and Chemistry
7:30 pm - 8:00 pm
"Chemical Tools to Intercept and Interrogate Bacterial Communication Pathways"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Organic Reactions Inspired by the Chemistry of Gold"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Discovery of TAK-243: An Investigational, First-in-Class Inhibitor of the Ubiquitin Activating Enzyme"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Paradigm Shifting Technology
9:00 am - 9:30 am
"Using Old Chemistry to Find New Cancer Targets"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Engineered Protein Switches for Studying Dynamic Cellular Processes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Improving Our Approach Towards Gram-Negative Drug Discovery"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Innovation in the Synthesis of Complex Pharmaceuticals"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Novel Benzamide Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Complex Molecular Drug Discovery
7:30 pm - 8:00 pm
"Lifting the Body's Energy Embargo"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Design, Syntheses and Studies of Antibiotics to Circumvent Bacterial Resistance"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Inhibitors of HIV-1 Maturation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Natural Product-Inspired Medicinal Chemistry
9:00 am - 9:30 am
"Discovery, Target Identification and Validation of a Novel Class of Potent Highly Selective Anti-Colon Cancer Small Molecules"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Can We Beat Nature? Rational Design, Chemical Syntheses and Molecular Mechanisms of Action of New Antibiotics Based on Old Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Design of Technology-Compatible Cyclic Peptide Scaffolds with Oral Bioavailability"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Optimization of the Arylomycin Natural Product into Gram-Negative Antibiotics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The State-of-the-Art of Discovery in Natural Products
7:30 pm - 8:15 pm
"Natural Product Sciences in Modern Drug Discovery and Paths to the Future"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
"Studies in Natural Product Synthesis"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure