Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Setting Notch in Context
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"Pathways Regulating Stem Cell Self-Renewal and Migration"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Wnt Signalling and Cancer"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion: Key Principles for Notch Signaling
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transcriptional Dynamics and Regulation
9:00 am - 9:20 am
"Interpretation of Notch Signaling Through Gene Regulatory Networks for T-Cell Specification"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Role of Notch Dimerization in Mouse Development and Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Duration of Notch Signal Underlies Cell-Specific Notch Dose Sensitivity"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Dynamic Ligand Encoding in the Notch Signaling Pathway"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structure and Function of Notch Transcription Complexes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"An RBPJ-Inducible System to Address Notch Signaling Requirements Throughout T-Cell Development In Vivo "
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling Interactions and Modulations
7:30 pm - 7:50 pm
"Structural Basis for Regulated Proteolysis by the Alpha-Secretase ADAM10"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Functional Features of Notch Ligands"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Roles of Fringe Genes in Notch Pathway Modulation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"How Do O-Glycans Affect Notch Function?"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Notch and Disease Mechanisms
9:00 am - 9:20 am
"Notch 3 Signaling in Small Vessel Disease and CADASIL"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Notch Signaling in Mammary Stem Cell Regulation and Breast Cancer Progression"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Notch Signaling in Muscle Satellite Cells"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Direct Conversions Between Mature Kidney Epithelial Cell Types Is Regulated by Endogenous Notch Signaling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Notch in Ventricular Development and Cardiomyopathy"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Notch-Mediated Programming and Reprogramming of Cardiac Conduction"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"How Notch in the Endothelium Controls Organ-Specific Metabolism"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Notch Signaling Is Required for the Emergence of Inflammatory Innate Lymphoid Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Dynamics and Cellular Organization
7:30 pm - 7:50 pm
"Synchronised Clocks and Autonomous Timers in Developmental Patterning"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Quantitative and Dynamic Analysis of a Notch Target Gene, Hes5"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Notch Dynamics and Developmental Patterning in Drosophila "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Notch's Links to an Adhesive-Cytoskeletal Regulatory Pathway"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cell and Niche Interactions
9:00 am - 9:20 am
"Notch Control of Stem Cell Quiescence in Brain Homeostasis and Glioma"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis "
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Notch Regulates Multiple Facets of the Skeletal Muscle Stem Cell Niche"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Interplay Between Notch Signaling and Tissue Polarity During Development and Regeneration of Zebrafish Neuromasts"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Delta-Notch Signaling in the Adult Intestine: A Deathly Dialogue that Keeps Cell Numbers in Check"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Notch Regulation of Cellular Plasticity in the Intestinal Stem Cell Niche"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"TAD-Mediated Transcriptional Interference Reveals a Tie2-Notch1 Signaling Axis During Regeneration of the Endothelial Bone Marrow Niche"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Stem Cells Safeguard the Differentiation Refractory Niche Environment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Late-Breaking Topics
Short presentations will be selected from among the submitted abstracts.
7:30 pm - 7:40 pm
"Tuning the Mechanosensitivity of Synthetic Notch Receptors"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Time-Resolved Transcriptomics in Neural Stem Cells Identifies a v-ATPase/Notch Regulatory Loop"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"NOTCH1 Protein Polarization in Response to Flow"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Evidence for Notch Signaling in C. elegans Without the Nicastrin/APH-2 Subunit of Gamma Secretase"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"The Notch Signaling Pathway Controls Basophil Responses During Helminth-Induced Type 2 Inflammation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Dynamics of Transcription from Notch-Responsive Enhancers"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Dynamics of Notch-Dependent Transcriptional Activation in Its Natural Context"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Notch, Cancer and Therapeutics
9:00 am - 9:20 am
"Modular Domains in Notch-Regulated Super-Enhancer and Drug Resistance in T-ALL"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"NOTCH-Driven 3D Regulome in Triple Negative Breast Cancer"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Notch Signaling in SCLC Development and Response to Therapy"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Hypoxia Selectively Augments Notch1 Signaling in Glioma Stem-Like Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Context-Specific Notch Target Genes in Epithelial Cancers"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Novel Therapeutic Strategies for Targeting Notch Signalling"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Discovery of a Selective Small Molecule Inhibitor of the NOTCH Transcriptional Activation Complex"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"γ-Secretase Inhibition Re-Sensitizes EGFR-Driven Lung Adenocarcinoma Harboring Gatekeeper Mutations to Tyrosine Kinase Inhibitors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Environmental Influences and Signaling Cross-Talk
7:30 pm - 7:50 pm
"Fine Tuning of NICD Stability Plays a Key Role in the Vertebrate Segmentation Clock"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Dysregulated Notch Signaling in the Vasculature"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"How Notch Directs Axon Growth in the Drosophila Wing"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Not(ch) Where It Should Be? Dynamic Phase Separation and Colocalization of Notch with Cadherin Choreographs Biochemical Reaction Sequences"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure