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Notch Signaling in Development, Regeneration and Disease (GRS)

Gordon Research Seminar

Mechanisms of Notch Signaling in Health and Disease

July 13 - 14, 2024

Chairs

and

Bates College

2 Andrews Road

Lewiston, Maine, United States

Venue and Travel Information

Conference Description

The Notch Signaling in Development, Regeneration and Disease GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Due to limited accommodations at this venue, guest housing is very limited. To request family/guest housing please reach out to your Conference Operations Associate.

Related Meeting

This GRS will be held in conjunction with the "Notch Signaling in Development, Regeneration and Disease" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Notch Regulatory Dynamics in Development and Disease Discussion Leader:
3:45 pm - 4:15 pm	"Transcriptional Decoding of Notch Signaling"
4:15 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Structural and Mechanical Biology of Notch Discussion Leaders: and
7:30 pm - 7:40 pm	"Modulation of NOTCH2-Ligand Binding by O-Glucose Glycan and its Xylosyl Elongation"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Development of a Synthetic Receptor with Modular Proteolytic Regulation"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Divalent Metal Transporter1(DMT1) Modulates Notch Signaling by Influencing Iron Storage and Lysosomal Stability"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Protein Design Approaches to Targeted Modulation of Notch Receptor Signaling"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Understanding A13 Mediated NOTCH3 Receptor Activation Mechanism"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Development of Notch Agonists Through Protein Engineering and Multivalent Scaffolds"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Heterogeneous Outcomes of Different Cadasil Mutants on Endocytic Notch3 Activation Mechanisms"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"The Notch ligand DLL1 defines a balance between trans-activation and cis-inhibition to regulate human somitogenesis"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Notch Signaling in Disease and Development Discussion Leaders: and
9:00 am - 9:10 am	"Neuralized-Like Proteins Differentially Activate Notch Ligands"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Unraveling the Role of TM2D3 (almondex) on Embryonic Development, Notch Proteolysis and Signaling"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Reducing Sinusoidal-Jag2 Impairs the Regenerative Potential of Hematopoietic Stem Cells by Inducing Notch Signaling Cis-Inhibition"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Notch Signaling Modulates the Quiescent State in Hematopoietic Stem Cells During Fetal Development"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Ovarian Cancer Metastasis Promoting CAF Subpopulations are Activated by Cancer Cell-CAF Crosstalk Mediated by the Jagged1-Notch3 Axis"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Exploring Transient Inhibition of Notch Signaling via mRNA Lipid Nanoparticles as a new Strategy to Prevent Graft-Versus-Host Disease"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Quantitative Understanding of Notch-Dependent Transcriptional Dynamics During Aging in Vivo"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Access to Stromal Delta-Like1 Notch Ligands in Splenic B Cell Follicles Controls the Positioning and Function of Marginal Zone B Cells"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Career Paths in Notch Signaling Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion The Notch Network: Career Journeys and Innovations in Signaling Science
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institutes of Health under Award Number 1R13HD114252-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Notch Signaling in Development, Regeneration and Disease

Registration Fees Additional Fee Info

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