Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: mRNA Therapeutics
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:35 pm
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Optical and Chemical Control of mRNA"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Water Purification to Remove Small-Molecule Contaminants Using Aptamer-Functionalized Membranes"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Small Molecule Recognition of DNA and RNA
9:00 am - 9:25 am
"Deciphering Patterns in Selective Small Molecule:RNA Interactions"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Targeting DNA and RNA Repeats that Cause Disease with Small and Not So Small Molecules"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"The Use of Synthetic Base Triples for Probing RNA Tertiary Interactions and siRNA Delivery"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Insights into Targeting Nucleic Acid Tertiary Structure with Small Molecules"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Base Pair Sequence and Minor Groove Shape in the Design of New Types of Cell-Permeable, DNA-Binding Agents"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Development of Splice-Switching Molecules as Inducers of Apoptosis"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis and Applications of Modified Oligonucleotides
7:30 pm - 7:55 pm
"Cyclopentane Locked Peptide Nucleic Acids"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Amide-Modified RNA Synthesis, Structure and RNA Interference Activity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Genetic Alphabet Expansion for Xenobiology"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Evaluation of Modified Unlocked Nucleic Acid (mUNA) on the Gene Silencing Activity of siRNA"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nucleoside/Nucleotide Drug Development
9:00 am - 9:25 am
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"HIV Nucleoside Reverse Transcriptase Translocation Inhibitors to Enable Extended Duration Dosing"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Azido-Substituted Nucleosides as Radiation Damage Enhancement Agents"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"New Series of Acyclic Nucleoside Phosphonates as Potent Antimalarials"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Phosphonate Nucleosides and Oligonucleotides"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Development of Nucleoside Prodrugs as Precision Medicine for BRCA-Deficient Cancers"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Oligonucleotide Therapeutics
7:30 pm - 7:55 pm
"Aiming for Ideality in the Synthesis of Oligonucleotides"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"RNAi-Based Modulation of Gene Expression in CNS"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Gene Editing by PNA Nanoparticles"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"From Stereopurity to Precision Medicine: Optimizing the Properties of Antisense Nucleic Acid Therapeutics"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fluorescence Imaging Agents
9:00 am - 9:25 am
"Stacking-Induced Fluorescence Increase as a Versatile Probe of DNA Structure and Dynamics"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Cationic Styryl Dyes for Dual-Mode Colorimetric and Fluorescence Sensing of DNA"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Live Cell Imaging of Telomerase Activity Using Hybridization-Sensitive Fluorescence Oligonucleotide Probes"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Employing the Functions of Aptamers Inside Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Isomorphic Fluorescent Nucleosides, Nucleotides and Oligonucleotides"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"PT(BPA)2+: A Fluorogenic Probe for Real-Time Tracking of RNA Quadruplexes in Cells"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Hachimoji DNA: An Expanded Genetic System"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Exciting Tetrahelical Structures of G-Rich DNA Repeats Beyond G-Quadruplexes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Pervasive RNA Binding by Transcription Factors"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Application of Anti-RNA Antibodies for RNA Crystallography and Beyond"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acids Chemical Biology
9:00 am - 9:25 am
"Biology and Therapeutic Potential of the MYC and kRAS Promoter G-Quadruplexes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Nucleic Acids and the Control of Gene Expression in Cell Nuclei"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Chemical Approaches to Illuminate the Epitranscriptome"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"The Watson-Crick World Is Not Enough"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Design of Bivalent Nucleobases for Targeting Double-Stranded DNA and RNA"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Heterochiral DNA Circuitry: Interfacing Oligonucleotide Enantiomers in Living Cells"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Modification and Repair
7:30 pm - 7:40 pm
"An Orthogonal Chromatin Landscape for Transcriptional Reprogramming"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:10 pm
"DNA Repair in Nucleosomes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"The Impact of Oxidative DNA Base Damage on Telomere Maintenance"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Base Modifications at the Intersection of DNA Repair and Gene Expression"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure