2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Small Molecules and Oligomers for the Study, Diagnosis and Treatment of Disease
Leah Seebald (Massachusetts Institute of Technology, USA)
3:45 pm - 4:15 pm
Mark Saltzman (Yale University, USA) "Polymer Nanomaterials as Delivery Systems for Oligonucleotides"
4:15 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Improved Molecular Recognition Using Small Molecules and Oligomers
Colin Swenson (Emory University, USA)
7:30 pm - 7:40 pm
Leah Seebald (Massachusetts Institute of Technology, USA) "Synthetic Solvatochromic Nucleosides as Sensors for Glycosyltransferases"
7:40 pm - 7:45 pm
7:45 pm - 7:55 pm
Giacomo Padroni (Duke University, USA) "Investigating RNA Structural Motifs Using Small Molecule-Based Pattern Recognition"
7:55 pm - 8:00 pm
8:00 pm - 8:10 pm
Pavel Kielkowski (Technische Universität München, Germany) "A Pronucleotide Probe for Functional Analysis of Protein AMPylation During Neuronal Differentiation"
8:10 pm - 8:15 pm
8:15 pm - 8:25 pm
Adam Mamot (University of Warsaw, Poland) "Bioorthogonal Labelling of Modified mRNA with Increased Translational Efficiency in Living Cells"
8:25 pm - 8:30 pm
8:30 pm - 8:40 pm
Misael Romero-Reyes (Emory University, USA) "Water Purification to Remove Small-Molecule Contaminants Using Aptamer-Functionalized Membranes"
8:40 pm - 8:45 pm
8:45 pm - 8:55 pm
Young-Jin Cho (WAVE Life Sciences, USA) "Assigning Positional Stereochemistry for Stereopure Oligonucleotides"
8:55 pm - 9:00 pm
9:00 pm - 9:10 pm
Shane Byrne (Johns Hopkins University, USA) "When Biological Machines Encounter Reversible Crosslinks in Duplex DNA"
9:10 pm - 9:15 pm
9:15 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Synthetic Modifications for Optimized Nucleic Acid Therapeutics
Giacomo Padroni (Duke University, USA)
9:00 am - 9:10 am
Venubabu Kotikam (Binghamton University, State University of New York (SUNY), USA) "Syntheses and RNAi Activity of Amide-Modified siRNAs"
9:10 am - 9:15 am
9:15 am - 9:25 am
Anaïs Depaix (University of Warsaw, Poland) "Synthesis and Incorporation into RNA of NAD Analogues: New Tools to Study Decapping Enzymes"
9:25 am - 9:30 am
9:30 am - 9:40 am
Mary Yates (University of Maryland, Baltimore County, USA) "Investigations into the Mechanism of Action of Flexible Nucleoside Analogues Against Flaviviruses"
9:40 am - 9:45 am
9:45 am - 9:55 am
Nikita Brodyagin (Binghamton University, State University of New York (SUNY), USA) "Nucleobase Modifications to Improve Triple Helical Recognition of dsRNA and Cellular Delivery of PNA"
9:55 am - 10:00 am
10:00 am - 10:10 am
Viktoriya Anokhina (University of Rochester Medical Center, USA) "Improving Efficiency of HIV-1 FSS RNA-Targeting Compounds"
10:10 am - 10:15 am
10:15 am - 10:25 am
Molhm Nassir (Bar-Ilan University, Israel) "Development of NPP1 Inhibitors as Potential Drugs for the Treatment of Osteoarthritis/CPPD Disease"
10:25 am - 10:30 am
10:30 am - 10:40 am
Kirsten Deprey (Tufts University, USA) "Using the Chloroalkane Cell Penetration Assay (CAPA) for the Optimization of RNA Therapeutics"
10:40 am - 10:45 am
10:45 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: The Journey from Academia to Industry and Back Again
The 2019 GRS on NNO is unique because of the participation by the panel members who are established leaders in academia and the industry. The first half of the mentorship component will commence with a brief description of the professional journey traversed by each panel member and the second half will conclude with an open question and answer session where GRS participants can take full advantage of the immense cross-disciplinary expertise available on the floor.
Shane Byrne (Johns Hopkins University, USA)
1:30 pm - 2:30 pm
The Journey from Academia to Industry and Back
John Randolph (Roche Molecular Systems, USA)
Jessica Rouge (University of Connecticut, USA)
Mark Saltzman (Yale University, USA)
2:30 pm - 3:00 pm
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