Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Quantitative Analyses of Redox Changes
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:40 pm
"Quantitative Analyses of Redox and Electrophile Reactive Thiol Proteomes"
8:40 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondria and Oxidant Signaling
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Site-Specific ROS Signalling in Health and Disease"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Mitochondrial-Nuclear Genetic Interaction as a Mechanism for Modulating Metabolism and Gene Expression"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice"
10:20 am - 10:25 am
Discussion
10:25 am - 10:30 am
General Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Platelet Mitochondrial ROS Signaling: To Clot or Not"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Nitric Oxide, Metabolism and Mitochondria Cross Talk"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Myoglobin Regulates the Function of the E3 Ligase Parkin to Modulate Mitochondrial Fusion and Decrease Breast Cancer Tumor Progression"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Roles of Oxygen Radicals in Cancer Etiology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Role of Hypoxia in Mediating Epigenetic Changes in Pediatric Neuroblastoma"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Optochemical-Targeted Mitochondrial Dysfunction Gives Insights into Mitochondria-Nuclear Crosstalk"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Cancer as Iron Addiction with Ferroptosis-Resistance"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Reprogramming Redox Tone and Bioenergetic Health in Cancer by Regulation of Lysosomal Biogenesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Interface Between Nitrogen and Oxygen Radicals
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Following NO in the Progression Cancer: Insight into Mechanism of Poor Outcome"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Modulation of Metabolic Function by Nitrate and Nitrite"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Kinetic and Quantum Mechanical Study on the Decomposition of Piloty's Acid Derivatives Toward the Understanding of Factors Controlling HNO Release"
10:20 am - 10:25 am
Discussion
10:25 am - 10:30 am
General Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Progress on How Radicals Killed Lou Gehrig (ALS). The Interplay of Copper, SOD, Peroxynitrite and Tyrosine Radicals in Motor Neuron Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"The Chemical Biology of Hydropersulfides: Possible Roles in Redox Signaling"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Reactions of Tryptophan Radicals on Peptides and Proteins: Dimersation vs Addition of Superoxide to Give Hydroperoxides"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Altered Redox Signaling Responses to Nanoparticles in Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Peroxiredoxin Involvement in Cellular Redox Signalling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Redox Regulation of Protein Tyrosine Kinases: New Twists and Turns"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"The Pathways for Repair of Peroxidized Cell Membranes"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging, Sensing, and Quantification of Oxidants and Oxidant Damage
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Effects of Developmental ROS on Stress Resistance and Lifespan"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"In Vivo Imaging Biomarkers from EPR Based Techniques to Guide Treatment and Monitor Treatment Response: Pre-Clinical and Clinical Studies"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Hydrogen Peroxide Sensors as Tools to Quantify H2 O2 in Living Systems"
10:20 am - 10:25 am
Discussion
10:25 am - 10:30 am
General Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Recent Advances in Specific Detection of Superoxide"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Isotope-Reinforced Polyunsaturated Lipids (D-PUFAs), Lipid Peroxidation, and Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Ablation of Glutathione-S-Transferase p Attenuates Glycolysis in House Dust Mite-Induced Allergic Airways Disease"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Physiological Responses to Oxidation
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Redox Regulation of Protein Kinase G – Translational Opportunities"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Stress Response Signaling via the Keap1-Nrf2 Pathway"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"The NADPH Oxidase Nox4 as a Key Player in Differentiation"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"To Adapt or Not to Adapt: The Consequences of an Age-Dependent Decline in the Adaptive Homeostatic Response"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Oxygen Radicals, Tissue Damage, and Therapeutics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Myeloperoxidase Contributes to the Destabilisation of Atherosclerotic Plaques"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Imaging Myeloperoxidase Activity"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Convergence of Golgi Stress Response and Cysteine Metabolism Confers Cytoprotection in Huntington's Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Novel Redox Modifications of Proteins: Pathways to Protein Degradation, Aggregation and Immunogenicity"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"The Role of Hypobromous Acid in Tissue Biology"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Unraveling the Mechanism of Selenium Catalysis in GPx4: How Redox Chemistry Impacts on Life from Sperm Function to Embryogenesis and Cell Death"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Redox Paradigm – Where to Now?
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 9:10 pm
"OH NO: NOX, NOS and ROS! Where Do We Go?"
9:10 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure