Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Informing Etiology Through the Clinic
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:15 pm
Introduction by Discussion Leader
8:15 pm - 9:00 pm
"What Is Parkinson's Disease and Why Is It Important for Understanding Biology"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Parkinson's Disease Genetics and Systems Biology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Glucocerebrosidase, Glycosphingolipids and Parkinson's Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Autoimmune Mechanisms in Parkinson's Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Applications of Functional Genomics to Parkinson's Disease"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"High-Content Screening and Genomic Approaches for PD"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Genetics and Biology of Nigral Vulnerability"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Targeting Lysosomal GBA Deficiency for Parkinson's Disease: From Genetics to Therapeutics"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene-Environment Interaction
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Advancing Parkinson's Disease Research by Using Clues from the Environment"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Gene-Environment Interactions in PD: Role of Efflux Transporters"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Assessing Gene-Environment Interactions: Success Stories in Parkinson's Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Synergy Between Common Genetic Variant in Antigen Presentation Capacity and Pyrethroid Exposure Affects Peripheral Immunophenotype and Nigrostriatal Pathway Vulnerability"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
LRRK2: From Protein, Through Cell Biology to Therapeutic Intervention
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"New Assays and Pathways that Activate LRRK2"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"LRRK2 and Macroautophagy: Standing at a Crossroads for Human Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"LRRK2, Mitochondrial DNA Damage and Biomarkers"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"LRRK2 Inhibition in Mediating Alpha-Synuclein Neurotoxicity"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Challenges of Neurodegenerative Disease Drug Discovery: BACE Inhibitors for Alzheimer's Disease vs. LRRK2 Inhibitors for Parkinson's"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Searching for Druggable Targets Using In Silico Simulation of LRRK2 Pathways"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biology of Aging and Parkinson's Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Generation of Human Neurons by microRNA-Based Neuronal Reprogramming and Modeling of Neurodegeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Targeting Molecular Pathways of Aging as a Treatment Strategy for Parkinson's Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Proteostasis in Biology, Aging, and Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Evidence for Compartmentalized Changes in Neuronal Mitochondrial Biogenesis in a PD-Relevant Model: Assessment of Mitochondrial DNA Replication in Neuron Cell Bodies, Axons, and Dendrites"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Handling and Trafficking
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"PARK14-Dependent Calcium Signaling Is a New Determinant of Autophagic Dysfunction, a-Synuclein Aggregation and PD"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Propagation of Alpha-Synuclein Pathology Along Neural Pathways"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Signaling Pathways for New Axon Growth in Adult Dopamine Neurons"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Molecular Determinants of Alpha-Synuclein Handling in the Cell"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mechanisms of VPS35-Dependent Neurodegeneration in PD"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"A Link Between Infection, Autoimmune Mechanisms and Parkinson's Disease"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Parkinson's Disease Models: Improving Predictive Value
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Generation of Dopaminergic Systems by Means of Neuronal Transdifferentiation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Prion-Like Dissemination of Human Brain-Derived Alpha-Synuclein in Mice and Monkeys"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"A Progressive, Endogenous Synucleinopathy Model of Parkinson's Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Microglia Influences Prion-Like Propagation of Alpha-Synuclein"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
SNCA: From Protein, Through Cell Biology to Therapeutic Intervention
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"iPS Cell Technology and the Study of Simple and Complex Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Prion-Like Propagation of Alpha-Synuclein Assemblies in Synucleinopathies"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Removal of Alpha-Synuclein from Mature Nigral Neurons In Vivo Results in Toxicity and Neurodegeneration"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Alpha-Synuclein Knockdown Is a Promising Therapeutic Strategy for Parkinson's Disease"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"The Aducanumab Story: Lessons Learned from Early-Phase Anti-Amyloid mAb Development for Design of PD Clinical Trials"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Shifting Synuclein Tetramers to Monomers Yields Mice with p-Syn Deposits, TH Loss, Tremor, and Motor Deficits Responsive to L-DOPA"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Inflammation and Immunity in Parkinson's Disease
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:00 pm
"Neuroinflammation in Parkinson's Disease"
6:00 pm - 6:10 pm
Discussion
6:10 pm - 6:30 pm
"Models, Mechanisms, and Therapeutic Interventions"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"The Dynamic Immune Response in PD"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Modulation of Inflammation via Cannabinoid Type 2 Receptors to Protect Against Asyn-Induced Degeneration"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure