Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: On the Cusp of Transformative Treatments
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"Define, Measure, Treat: The Parkinson's Roadmap"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Utilizing New Tools to Study Dopamine and Basal Ganglia Function
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Dysregulated Striatal Activity in Parkinsonism and Levodopa-Induced Dyskinesia"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Insights About Parkinson's Pathophysiology Using a Gradual 6-OHDA Depletion Model"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Imaging the Effects of Dopamine Agonists and Antagonists on Dopamine Neuromodulation with a Near-Infrared Nanosensor"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"A New Way to Study Brain Dynamics, Drugs and Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"High Resolution Imaging of Dopamine Dynamics with Designed Genetically-Encoded Indicators"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Using Mouse Cell-Type-Specific Neuroanatomical Location of GWAS-Implicated Genes to Identify Vulnerable Cell Types and Circuits in Parkinson's Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dopamine Oxidation and Other Oxidative Stressors in Pathogenesis
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Dopamine Oxidation, Glucosylceramide and α-Synuclein"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Oxidative Modulation of LRRK2 Kinase Activity in Parkinson's Disease Pathogenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Dopamine Oxidation Mediates Convergence of Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Pharmacological Modulation of FXR-TFEB Signaling Improves Mitochondrial Function and Prevents Age-Related Neurodegeneration"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Parkinson's Proteins in Immune Cells
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"GBA-Associated Parkinson Disease in TASMC Cohort: Inflammatory Aspects"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Parkin, PINK1 and Inflammation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Peripheral Immune Regulation of LRRK2-Mediated Neurodegeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"LRRK2-Mediated NFAT and Wnt Signaling in Innate Immune Responses"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Leveraging PBMCs to Guide the Clinical Interrogation of LRRK2 Kinase Inhibitors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Parkinson Disease-Associated Mutations in LRRK2 Induce Mislocalization of Rab8a and Modulate Transferrin Recycling in Primary Microglia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Single-Cell Profiling Technology: Methods and Results
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Emerging Technologies in Extracellular RNA Profiling and Single Extracellular Vesicle Characterization"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Cell Type-Specific Translational Profiling in Mouse Models of Huntington's Disease Reveals Molecular Mechanisms Shared with Parkinson's Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Using Single-Cell Transcriptomics Data to Investigate Metabolic Characteristics and Selective Vulnerability of Dopaminergic Neurons in Mouse Models of PD"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Identifying Parkinson's Disease Risk Factors Using Mendelian Randomization"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Uptake, Release and Transmission of α-Synuclein
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Formation and Clearance of α-Synuclein Seeds in Neuronal and Oligodendroglial Cells"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Role of FcgammaRIIB Signaling in Parkinson's Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"A Role for TLR2 in Mediating α-Synuclein Pathology in Parkinson's Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"TM9SF2 as a Novel Receptor for α-Synuclein Fibrils"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Role of Tunneling Nanotubes in the Spreading of α-Synuclein"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"SNCA Targeted Antisense Oligonucleotides Modulate Progression of Pathological Deposition in Alpha Synuclein Rodent Transmission Models of Parkinson's Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Investigating the Function of Parkinson's Disease-Associated Genes in iPSC-Derived Macrophages and Microglia"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Generation of Pathophysiological Midbrain Organoid Model of Parkinson's Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Loss of Functional Mitochondrial Complex I in Dopaminergic Neurons Triggers a Progressive Parkinsonian Phenotype"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Environmental Toxicant, Trichloroethylene, Activates LRRK2 and Causes Nigrostriatal Degeneration"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Gut-Brain Axis in Pathogenesis
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"PD: It's Not All in Your Head"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"The Enteroendocrine Cell-Neural Circuit: Implications for the Spread of α-Synuclein"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Functional Roles for the Gut Microbiome in Experimental Models of PD"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Searching the Intestinal Environment for Clues to the Etiology of Parkinson's Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Gut-First vs. Brain-First Parkinson's Disease: A Hypothesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"LRRK2: Lurking Between the Brain and Gut"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Parkinson's Biomarker Development
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 6:05 pm
"Updating Our Definitions of Parkinson's Disease for a Molecular Age"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:35 pm
"Peripheral Mitochondrial Function as a Surrogate Measure of PD Severity and Its Usefulness in Patient Stratification"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Neuromelanin Detection by Magnetic Resonance Imaging, a Potential Biomarker for Parkinson's Disease"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Progressing a LRRK2 ASO Towards Phase 1 Clinical Studies"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure