Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Next or New Opportunities in the Plasminogen Activation and Extracellular Proteolysis Field
Session in memory of Ed Reich and Russell Doolittle.
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:30 pm
"Understanding the Molecular Regulation of Plasminogen Activation as a Key to Future Fibrinolysis Research"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Fibrinolysis Research: A Look Back and Forward"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cardiovascular Function and Coagulopathies
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Proteolytic Regulation of Platelet Receptor Levels in Patients with Cardiovascular Complications"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Mechanisms Linking Fibrinogen and Fibrinolysis to Liver Repair"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Alpha-2-Macroglobulin and Hemostasis Disorders in Chronic Inflammatory Diseases"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Activated Platelet Membrane: A Key Site for Plasminogen Activation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Evolution of Defining Fibrinolysis Dysfunction Following Severe Injury"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Role of TAFI in Hemophilic Arthropathy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"The Multifaceted Role of Fibrin/Fibrinolysis in Musculoskeletal Biology"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Roles of Plasminogen Activator Inhibitor-1 in Bone Metabolism"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Fibrin Is a Critical Regulator of Mucosal Immunopathology"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"The Yin and Yang of Neutrophil Elastase in Muscle Regeneration and Dystrophy"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Diseases and Aging
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Association of Adipose Tissue Factor XIII-A with Metabolic Health in Mice and Humans"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Assessing In Situ Plasmin Generation in Health and Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Prothrombotic Complications and Resistance to tPA-Mediated Fibrinolysis in Sickle Cell Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Macrophages by Plasmin During Liver Repair"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Protective Effects of a High Fat Diet on Alzheimer's Disease Pathophysiology"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"14K Fragment of Growth Hormone and Its Derived Peptides Promote Fibrinolysis and Protect from Thrombosis by Binding Plasminogen Activator Inhibitor"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Time-Dependent Role of Plasmin in Muscle Repair and New Considerations for Antifibrinolytic Drug Administration Following Trauma and Surgery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"The Fibrinolytic System Orchestrates the Development of Inflammation and Inflammation-Associated Carcinogenesis in the Proteolytic Niche"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"TAFI and Thrombomodulin as Inhibitors of Breast Cancer Metastasis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"PA System in Skin Cancer Progression"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Urokinase Receptor as a 'Trap' for Urokinase: Binding of uPA to uPAR Prevents Nuclear Translocation of uPA and EMT in Neuroblastoma Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Technologies and Therapeutic Advances
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Magnetically Powered Microbots for Fibrinolysis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"uPAR Inhibitory Nanomedicine for Targeted Treatment of Sterile Inflammatory Diseases"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Thrombin Signaling Promotes Pancreatic Adenocarcinoma Through PAR-1-Dependent Immune Evasion"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Defining High-Risk Heart Failure with Preserved Ejection Fraction Through Inflammatory Burden: The Role of sUPAR"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Multi-Channel Fluorescent Imaging of Hemostatic Proteases for the Monitoring of Therapeutic Efficacy"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Resistance to Fibrinolysis and New Thrombolytic Strategies: Insights from Intravital Microscopy, Microfluidics and Ex Vivo Thrombolysis Assays"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Spatiotemporal Regulation of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Activation on Activated Platelets"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Urokinase Regulates N-Cadherin-Mediated Synaptic Formation in the Ischemic Brain"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Plasmin(ogen) and the Traumatically Injured Patient: Friend or Foe?"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Hepatocyte-Derived tPA Regulates Systemic Fibrinolysis"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"PAI-1 Drives the Development of Lung Fibrosis Through Novel Protein Interactions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The Role of Localized Proteolytic Environments in Group A Streptococcal Pathogenesis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Membrane-Anchored Serine Proteases in the Regulation of Vascular Permeability"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"SuPAR as Endogenous Immunotoxin for the Kidney"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Extracellular Proteases in Sepsis: Translating Basic Research to Precision Medicine"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Plasminogen Activator Inhibitor-1 (PAI-1) Targeted Fibrinolytic Therapy in Rabbit Empyema Model"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"New Horizons in Translating Selective Anti-MMP Biological Inhibitors into the Clinic"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Derangements of uPA and PAI-1 Activity in Severe Cases of Hantavirus Cardiopulmonary Syndrome"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Modulation of Fibrinogen/Fibrin Levels Affects the Outcome of Enterococcal Catheter-Associated Urinary Tract Infections"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Fibrinogen Deficiency Leads to Stabilization of 14-3-3-Sigma and P53 Which Control Colorectal Adenocarcinoma Growth"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurological and Neuropsychiatric Diseases
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Cerebrovascular Pathology in Cognitive Impairment"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"tPA Modulation of the Blood-Brain Barrier"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Proteolytic Regulation of Glial Activation and Neuroinflammation"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"New Thrombolytic Therapies for Ischemic Stroke"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure