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Cerebellum
Gordon Research Conference

Novel Perspectives on Cerebellar Development, Physiology, and Disease

Dates

July 30 - August 4, 2017

Location

Bates College
Lewiston, ME Site Information

Organizers

Chairs:
Thomas S. Otis & Amy Bastian

Vice Chairs:
Megan R. Carey & Javier F. Medina

Application Deadline

The application deadline for this meeting was July 2, 2017. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

The 4th Gordon Research Conference on the Cerebellum will bring together leading scientists and their trainees who are on the forefront of research on the cerebellum. The cerebellum is a brain structure that is critical for learning and controlling movement, and has more recently been implicated in sensory and cognitive functions. The conference will highlight new advances in understanding cerebellar function at the genetic, cellular, circuit and behavioral level and its role in disease states ranging from ataxia to autism. We plan to highlight the newest findings in the field, such as the recently discovered long-range cerebellar connections to other parts of the brain as well as the role of the cerebellum in psychiatric diseases. The major goal of this meeting is to bring together a diverse set of international speakers and trainees in order to enable the exchange of information that would not be possible otherwise. This interaction is essential for developing new ideas and technical methods for understanding the fundamental operation of the cerebellum and novel treatments for human disease.

Related Meeting

This GRC will be held in conjunction with the "Cerebellum" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Molecular, Cellular and Synaptic Physiology of the Cerebellum
Discussion Leader: Stephen Lisberger (Duke University, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:10 pmIntroduction by Discussion Leader
8:10 pm - 9:00 pmMasunobu Kano (The University of Tokyo, Japan)
"Molecular, Cellular and Circuit Mechanisms of Developmental Synapse Elimination in the Cerebellum"
9:00 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCerebellar Development and Patterning
Discussion Leader: Roy Sillitoe (Baylor College of Medicine, USA)
9:00 am - 9:25 amMary Beth Hatten (The Rockefeller University, USA)
"Mechanisms of Cerebellar Development: Migration, Circuit Formation and Synaptic Plasticity"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amSuzana Herculano (Vanderbilt University, USA)
"Cerebellar Folding: Clade-Specific Spatial Patterns with Universal Degree of Folding Independent of Numbers of Neurons"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amRichard Apps (University of Bristol, United Kingdom)
"Cerebellar Contributions to Goal Directed Movements"
11:15 am - 11:30 amDiscussion
11:30 am - 11:50 amAmanda Therrien (Kennedy Krieger Institute, USA)
"Reinforcement Training Can Reduce Reaching Ataxia"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic Ataxias and Sensorimotor Dysfunction in Disease
Discussion Leader: Henry Paulson (University of Michigan Health System, USA)
7:30 pm - 7:55 pmMandy Jackson (Center for Integrative Physiology, University of Edinburgh, United Kingdom)
"Glutamate Transporters: Multiple Roles in Cerebellar Function and Dysfunction"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmStefan Pulst (University of Utah, USA)
"Gene-Targeted Therapies for Degenerative Ataxias"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmAlanna Watt (McGill University, Canada)
"Understanding and Reversing Pathophysiological Changes in a Mouse Model of Spinocerebellar Ataxia Type 6 (SCA6)"
9:15 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLong Range Circuit Interactions Involving the Cerebellum
Discussion Leader: Adam Hantman (Janelia Research Campus, Howard Hughes Medical Institute, USA)
9:00 am - 9:25 amClement Lena (Ecole Normale Superieure, France)
"The Dialogue Between the Cerebellum and the Sensory-Motor Cortices"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amKamran Khodakhah (Albert Einstein College of Medicine, USA)
"Cerebellar Modulation of the Dopaminergic Reward Pathway"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amLiqun Luo (Stanford University, USA)
"Imaging Granule Cells in Behaving Mice"
11:15 am - 11:30 amDiscussion
11:30 am - 11:50 amCatarina Albergaria (Champalimaud Centre for the Unknown, Portugal)
"Locomotor Activity Modulates Associative Learning in Mouse Cerebellum"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmLe Xiao (Biozentrum University of Basel, Switzerland)
"A Circuit Framework for the Regulation of Striatal Function by Cerebellar Outputs"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNeurophysiology of Sensorimotor Circuits and Cerebellar Behavior
Discussion Leader: Jennifer Raymond (Stanford University School of Medicine, USA)
7:30 pm - 7:55 pmAbigail Person (University of Colorado School of Medicine, USA)
"Evaluating the Role of Cerebellar Output in Skilled Movement"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmEiman Azim (Salk Institute for Biological Studies, USA)
"A Propriospinal Internal Feedback Circuit for Skilled Reaching"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmKathleen Cullen (Johns Hopkins University School of Medicine, USA)
"Internal Models of Voluntary Self-Motion in the Cerebellum: Implications for Perception and Action"
9:15 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular and Synaptic Function in the Cerebellum
Discussion Leader: Ruth Mary Empson (University of Otago, New Zealand)
9:00 am - 9:25 amDavid Digregorio (Institut Pasteur, France)
"Influence of Dynamic Synapses on Cerebellar Cortical Circuit Computations"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amWade Regehr (Harvard Medical School, USA)
"Purkinje Cell Collaterals"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amMarylka Uusisaari (Okinawa Institute of Science and Technology, Japan)
"Dendritic Architecture and Dynamic Activity Clustering in the Inferior Olive"
11:15 am - 11:30 amDiscussion
11:30 am - 11:50 amGeoffrey Pitt (Weill Cornell Medicine, USA)
"Regulation of Na+ Channels and Excitability in Purkinje Neurons by Auxiliary Subunits"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAudrey Bonnan (Max Planck Florida Institute, USA)
"Cerebellar-Dependent Motor Memory Depends on Patterned Changes in Molecular Layer Interneuron Activity"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmComputational and Behavioral Studies in the Cerebellum
Discussion Leader: Daniel Wolpert (University of Cambridge, United Kingdom)
7:30 pm - 7:55 pmPeter Thier (University of Tübingen, Germany)
"The Role of the Cerebellum in Coping with Cognitive Fatigue"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmJoern Diedrichsen (Western University, Canada)
"In Search of the Universal Transform: Mapping Cortico-Cerebellar Loops Across a Broad Spectrum of Functional Domains"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmMehrdad Jazayeri (Massachusetts Institute of Technology, USA)
"A Cerebellar Model for Learning Statistics of Time Intervals"
9:15 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeural Processing in the Cerebellar Cortex
Discussion Leader: Rondi-Reig Laure (Pierre and Marie Curie University / CNRS, France)
9:00 am - 9:25 amAngus Silver (University College London, United Kingdom)
"The Ins and Outs of the Granule Cell Layer"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amMartijn Schonewille (Erasmus University Medical Center, The Netherlands)
"Unraveling Cerebellar Function: Module-Related Differences in Activity and Learning"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amIsabel Llano (CNRS, France)
"Calcium Imaging of Molecular Layer Interneurons in Behaving Mice"
11:15 am - 11:30 amDiscussion
11:30 am - 11:50 amRuben Portugues (Max Planck Institute of Neurobiology, Germany)
"Sensorimotor Representations in Cerebellar Granule Cells of the Larval Zebrafish"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmHana Ros (University College London, United Kingdom)
"3D Two-Photon Imaging of Defined Mossy Fibre Inputs in Cerebellar Cortex in Awake Behaving Mice"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Cerebellar Dysfunction in Psychiatric Disease
Discussion Leader: Chiadi Onyike (Johns Hopkins University School of Medicine, USA)
7:30 pm - 7:55 pmJeremy Schmahmann (Massachusetts General Hospital / Harvard Medical School, USA)
"Cerebellar Cognitive Affective Syndrome"
7:55 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmSamuel Wang (Princeton University, USA)
"How the Cerebellum Shapes Nonmotor Behavior in Adulthood and Development"
8:40 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGeneral Discussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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