Conference Description
Efforts to understanding the mechanism of protein folding have driven the development of the energy landscape theory of protein folding, novel experimental tools for probing folding with high temporal and spatial resolution as well as new methods for computer simulation and analysis of rich data. These fundamental tools and principles can now be used to investigate the central role played by protein folding, misfolding and aggregation in human disease, and how folding is affected by the complex environment in cells.
In this conference, we will bring together leading experts in the field who are developing state of the art methods for studying folding and misfolding in a cellular context. For example, the program will include speakers covering co-translational protein folding on the ribosome, mechanisms of protein misfolding and amyloid formation and development of therapeutics, conformational dynamics in proteins and enzyme allostery, lessons from functional amyloid systems, design principles for new protein functions, and tuning of protein folding by small ligands as well as folding in the cell.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by September 9, 2021. Please check back for updates.
Keynote Session: Protein Interactions and Design
Discussion Leaders
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Martin Gruebele (University of Illinois at Urbana-Champaign, USA)
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Caitlin Davis (Yale University, USA)
Speakers
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Angela Gronenborn (University of Pittsburgh, USA)
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Stephen Mayo (California Institute of Technology, USA)
SARS-COV-2 Proteins
Discussion Leaders
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Alex Guseman (University of Pittsburgh School of Medicine, USA)
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Naomi Latorraca (University of California, Berkeley, USA)
Speakers
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Pamela Bjorkman (California Institute of Technology, USA)
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Alex Holehouse (Washington University School of Medicine, USA)
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Anum Glasgow (University of California, San Francisco, USA)
In Vivo Folding
Discussion Leaders
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Benjamin Schuler (University of Zurich, Switzerland)
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Andrea Soranno (Washington University in St. Louis, USA)
Speakers
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Patricia Clark (University of Notre Dame, USA)
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Gunnar von Heijne (Stockholm University, Sweden)
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Judith Frydman (Stanford University, USA)
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Paula Booth (King's College London, United Kingdom)
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Stephen Fried (Johns Hopkins University, USA)
Protein Misfolding and Amyloid Formation
Discussion Leaders
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Elizabeth Meiering (University of Waterloo, Canada)
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Michael Kovermann (University of Konstanz, Germany)
Speakers
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Joan-Emma Shea (University of California, Santa Barbara, USA)
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Jeremy Schmit (Kansas State University, USA)
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Elin Esbjörner (Chalmers University of Technology, Sweden)
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Liliana Quintanar (Center for Research and Advanced Studies (Cinvestav), Mexico)
Protein Folding
Discussion Leaders
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Susan Marqusee (University of California, Berkeley, USA)
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Lauren Porter (National Library of Medicine, NIH, USA)
Speakers
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Lila Gierasch (University of Massachusetts Amherst, USA)
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Sheena Radford (University of Leeds, United Kingdom)
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Dave Thirumalai (University of Texas at Austin, USA)
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Jayant Udgaonkar (Tata Institute of Fundamental Research, India)
Functional Aggregation
Discussion Leaders
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Jose Onuchic (Rice University, USA)
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Ellinor Haglund (University of Hawaii at Manoa, USA)
Speakers
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Tanja Mittag (St. Jude Children's Research Hospital, USA)
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Margaret Sunde (University of Sydney, Australia)
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Peter Wolynes (Rice University, USA)
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Carlos Castaneda (Syracuse University, USA)
AI in Protein Science
Discussion Leaders
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Cecilia Clementi (Rice University, USA)
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Mohammed AlQuraishi (Columbia University, USA)
Speakers
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Payel Das (IBM Research, USA)
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Frank Noe (Freie Universität Berlin, Germany)
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Pratyush Tiwary (University of Maryland, College Park, USA)
Evolution in Folding and Misfolding
Discussion Leaders
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Alexander Schug (Forschungszentrum Jülich, Germany)
Speakers
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Brian Volkman (Medical College of Wisconsin, USA)
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Charles Brooks (University of Michigan, USA)
Keynote Session: Folding and Misfolding in Cells
Discussion Leaders
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Robert Best (National Institutes of Health, USA)
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Alexander Buell (Technical University of Denmark, Denmark)
Speakers
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Margaret Cheung (Pacific Northwest National Laboratory / University of Washington, USA)
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Jeffery Kelly (Scripps Research, USA)
