Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Protein Interactions and Design
Discussion Leaders: Martin Gruebele (University of Illinois at Urbana-Champaign, USA) and Caitlin Davis (Yale University, USA)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Angela Gronenborn (University of Pittsburgh, USA)
"The Awesome Power of 19F NMR: Protein Folding, Ligand Binding, PREs and Other Applications"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Stephen Mayo (California Institute of Technology, USA)
"Design, Construction and Testing of a Novel Class of Antibody-Drug Conjugates"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
In Vivo Folding
Discussion Leaders: Benjamin Schuler (University of Zurich, Switzerland) and Andrea Soranno (Washington University in St. Louis, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Patricia Clark (University of Notre Dame, USA)
"Synonymous Codon Substitutions and Protein Homeostasis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Gunnar von Heijne (Stockholm University, Sweden)
"Cotranslational Folding of Integral Membrane Proteins"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Judith Frydman (Stanford University, USA)
"Folding at the Ribosome: Cotranslational Events Shaping Cellular Proteostasis"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
Paula Booth (King's College London, United Kingdom)
"Co-Translational Membrane Protein Folding"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Stephen Fried (Johns Hopkins University, USA)
"Systematic Interrogation of Protein Refolding Under Cellular-Like Conditions"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Margaret Cheung (Pacific Northwest National Laboratory / University of Washington, USA) and Stephen Fried (Johns Hopkins University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
SARS-COV-2 Proteins
Discussion Leaders: Alex Guseman (University of Pittsburgh School of Medicine, USA) and Naomi Latorraca (University of California, Berkeley, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Pamela Bjorkman (California Institute of Technology, USA)
"Neutralizing Antibodies Against Coronaviruses"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Tyler Starr (Fred Hutchinson Cancer Research Center, USA)
"High-Throughput Surveys of Mutations that Modulate the Stability, Function and Antigenicity of the SARS-CoV-2 Receptor-Binding Domain"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Anum Glasgow (University of California, San Francisco, USA)
"The Mechanistic Basis for SARS-CoV-2 Neutralization in an Engineered Receptor Trap Therapeutic"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Alex Holehouse (Washington University School of Medicine, USA)
"Condensation and Phase Separation in SARS-CoV-2 Genome Packaging"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Misfolding and Amyloid Formation
Discussion Leaders: Elizabeth Meiering (University of Waterloo, Canada) and Michael Kovermann (University of Konstanz, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Joan-Emma Shea (University of California, Santa Barbara, USA)
"Self-Assembly of the Tau Protein: LLPS and Fibrillization"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Jeremy Schmit (Kansas State University, USA)
"Probing the Mechanism of Amyloid Formation with the HP Model"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Elin Esbjörner (Chalmers University of Technology, Sweden)
"Metals and Membranes in Amyloid Formation and Propagation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Liliana Quintanar (Center for Research and Advanced Studies (Cinvestav), Mexico)
"Metal Induced Aggregation of Human Lens Crystallins: Relevance to Cataract Disease"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Sheena Radford (University of Leeds, United Kingdom)
"Hotspots and Sequence Changes: Unpicking the Effect of Mutation on the Aggregation on an Aggregation-Prone Protein"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Folding
Discussion Leaders: Susan Marqusee (University of California, Berkeley, USA) and Lauren Porter (National Institutes of Health, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Dave Thirumalai (University of Texas at Austin, USA)
"On the Morphologies of Fibrils in Fused in Sarcoma (FUS) Protein"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Lila Gierasch (University of Massachusetts Amherst, USA)
"How Hsp70 Molecular Chaperones Bind Their Substrates with both Specificity but Promiscuity"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Jayant Udgaonkar (Tata Institute of Fundamental Research, India)
"Structural Characterization of Multiple Folding Pathways of a Small Protein"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Aggregation
Discussion Leaders: Jose Onuchic (Rice University, USA) and Ellinor Haglund (University of Hawaii at Manoa, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Tanja Mittag (St. Jude Children's Research Hospital, USA)
"How Phase Behavior Is Encoded in Intrinsically Disordered Low-Complexity Domains"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Peter Wolynes (Rice University, USA)
"Protein Dynamics of the Brain"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Margaret Sunde (University of Sydney, Australia)
"RHIM Amyloid-Based Mechanisms for Viral Sequestration of Host Necroptosis Machinery"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Carlos Castaneda (Syracuse University, USA)
"UBQLN2 and Ubiquitin-Mediated Phase Transitions: Implications for Protein Quality Control"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Short Talk Selected from Poster Abstracts
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Evolution in Folding and Misfolding
Discussion Leaders: Alexander Schug (Forschungszentrum Jülich, Germany) and Faruck Morcos (University of Texas at Dallas, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Brian Volkman (Medical College of Wisconsin, USA)
"Evolution of Metamorphic Fold-Switching Proteins"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Charles Brooks (University of Michigan, USA)
"Cooperativity and Allostery in the Folding-Binding Landscapes of Transcription"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Lucy Colwell (University of Cambridge, United Kingdom)
"Combining Evolutionary Information with Experimental Data to Design Proteins with Improved Functional Activity"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
AI in Protein Science
Discussion Leaders: Cecilia Clementi (Freie Universität Berlin, Germany) and Mohammed AlQuraishi (Columbia University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Payel Das (IBM Research, USA)
"Generative AI Models for Advancing Biologics Design"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Frank Noe (Freie Universität Berlin, Germany)
"Deep Learning for Protein Biophysics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Pratyush Tiwary (University of Maryland, College Park, USA)
"From Data to Noise to More Data with Generative AI-Augmented Biomolecular Simulations"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
Neelanjana Sengupta (Indian Institute of Science Education and Research Kolkata, India)
"Learning Rarely Sampled Features in Biomolecular Free Energy Surfaces: Expectation Maximized Molecular Dynamics"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Bin Zhang (Massachusetts Institute of Technology, USA)
"Unifying Coarse-Grained Force Fields for Folded and Disordered Proteins"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Folding and Misfolding in Cells
Discussion Leader: Robert Best (National Institutes of Health, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Margaret Cheung (Pacific Northwest National Laboratory / University of Washington, USA)
"From Protein Folding In Vitro to Hierarchical Assemblies In Vivo "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Jeffery Kelly (Scripps Research, USA)
"Understanding and Ameliorating Diseases of Protein Conformation"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure