Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Next-Gen Protein Processing |
| This session is dedicated in memorium for Dr. Donald F. Steiner, M.D., who co-founded this GRC 22 years ago, and who passed away since the 2014 Conference. |
| Discussion Leader: Iris Lindberg (University of Maryland School of Medicine, USA) |
7:40 pm - 7:50 pm | Introduction by Discussion Leader: The Legacy of Don Steiner |
7:50 pm - 8:15 pm | Peter Arvan (University of Michigan Medical School, USA) "The Story of Proinsulin Continues to Unfold" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Robert Day (Université de Sherbrooke, Canada) "PCSK6 Undergoes an
Oncogenic Alternative Splicing Switch in Cancer" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Bertrand Cariou (L'Institut du Thorax, Centre Hospitalier Universitaire (CHU) de Nantes, France) "The Biology and Genetics of PCSK9" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Generation of the Endolysosomal Pathway |
| Discussion Leader: Richard Mains (University of Connecticut Health Center, USA) |
9:00 am - 9:25 am | Avital Rodal (Brandeis University, USA) "The Lowe Syndrome Phosphoinositide Phosphatase
dORCL Maintains Innate Immunity Quiescence by Regulating Endosomal Trafficking" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA) "Ultrafast Endocytosis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Phyllis Hanson (Washington University School of Medicine in St. Louis, USA) "ESCRT-III Function in Endosomal Trafficking" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Robert Fuller (University of Michigan, USA) "Molecular Functions and Structural Features of Vps13 and Its Role in Diverse Membrane Transactions" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Melkam Kebede (University of Sydney, Australia) "A Single Nucleotide Polymorphism in the Pro-Domain of Sorcs1 Affects Sorcs1 Protein Processing" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Majid Khatib (INSERM / University of Bordeaux, France) "Proprotein Convertases (PCs) Mediate Epstein-Barr Virus Infection Through Glycoprotein B Cleavage: Amplification and Positive Feedback Loop" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Edward Anderson (Brown University, USA) "Effect of Alternative BMP Processing on Signaling Activity, Prodomain Complexes, and Development" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Views on Peptide Processing and Release |
| Discussion Leader: Kelly Ten Hagen (National Institutes of Health, USA) |
7:30 pm - 7:55 pm | Robert Edwards (University of California, San Francisco, USA) "Membrane Protein Sorting to the Regulated Secretory Pathway" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Seung Kim (Stanford University School of Medicine / Howard Hughes Medical Institute, USA) "Suppression of Insulin Output by the Decretin Hormones Limostatin and Neuromedin U" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Jonathan Sweedler (University of Illinois at Urbana-Champaign, USA) "Heterogeneity in Peptide Processing Measured via High Throughput Single Cell Mass Spectrometry" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Duy Tran (National Institutes of Health, USA) "Imaging Secretory Granule Dynamics and Regulated Exocytosis In Vivo" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulated Intramembrane Proteolysis |
| Discussion Leader: Nabil Seidah (Institut de Recherches Cliniques de Montréal (IRCM), Canada) |
9:00 am - 9:25 am | Regina Fluhrer (BioMedizinische Zentrum der LMU München, Germany) "SPPL3 - An Intramembrane Aspartyl Protease with Exciting Properties" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Michael Glickman (Memorial Sloan-Kettering Cancer Center, USA) "Role of the Rip1 Intramembrane Protease in M. tuberculosis Stress Resistance" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Joanne Lemieux (University of Alberta, Canada) "Rhomboid-Mediated Intramembrane Proteolysis in the Mitochondrion" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:10 am | Bernd Schroder (Christian-Albrechts-Universität zu Kiel, Germany) "SPPL2-Mediated Intramembrane Proteolysis Controls Pro-Atherogenic Signaling of the Receptor LOX-1" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Camilla Gustafsen (Aarhus University, Denmark) "Role for Mosaic Receptor SorLA/LR11 in Regulation of Extra-Hepatic PCSK9 Activity" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Sarah Neuman (University of Wisconsin-Madison, USA) "A Screen for Systemic Growth Regulators Reveals Hobbit, a Novel and Conserved Regulator of Insulin Secretion" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | General Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inter-Organelle Communication |
| Discussion Leader: Kristi Wharton (Brown University, USA) |
7:30 pm - 7:55 pm | Loydie Jerome-Majewska (McGill University, Canada) "Protein Transport by TMED2 Is Required for Liver Homeostasis" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Rajini Rao (Johns Hopkins University School of Medicine, USA) "Endosomal NHE: Linking Luminal pH to Cargo Fate in Neurological Disorders" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Gary Thomas (University of Pittsburgh, USA) "Endosome Trafficking Meets the Nuclear Transcriptional Machinery" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Julia Von Blume (Max Planck Institute of Biochemistry, Germany) "Cargo Sorting During Protein Secretion" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Takes on Dense Core Vesicles |
| Discussion Leader: Alan Attie (University of Wisconsin-Madison, USA) |
9:00 am - 9:25 am | Michele Solimena (Universität Dresden, Germany) "Insulin Granule Aging and
Rejuvenation" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Adam Linstedt (Carnegie Mellon University, USA) "Targeting
Golgi Processing for Novel Therapeutics" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Betty Eipper (University of Connecticut Health Center, USA) "Biosynthetic and Endocytic
Roles for PAM" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Heather Brohier (Case Western Reserve University, USA) "Linking DCV Exocytosis to Synapse Formation" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Naushad Moti (Duke-NUS Graduate Medical School, Singapore) "Site of Action of Wntless Revealed by Live Cell Imaging of Wnt Secretion" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Xingmin Zhang (University of Wisconsin-Madison, USA) "BAIAP3, a C2 Domain-Containing Munc13 Protein, Regulates Endosome Recycling to the Golgi and Affects the Early Secretory Pathway" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Antonio Santos (Centre for Genomic Regulation (CRG), Spain) "The Novel Chimeric Protein Mia2/cTAGE5 Loads Pre-Chylomicrons/VLDLs at Endoplasmic Reticulum Exit Sites for Their Export" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Processing Enzymes in the Secretory and Endocytic Pathways |
| Discussion Leader: Lloyd Fricker (Albert Einstein College of Medicine, USA) |
7:30 pm - 7:55 pm | Galia Blum (Hebrew University of Jerusalem, Israel) "Where Do Proteases Function During Stress?" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | John Creemers (KU Leuven, Belgium) "The Role of PREPL in Regulated Secretion" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Klaudia Brix (Jacobs University Bremen, Germany) "Interactions Between Cysteine Cathepsins and GPCRs in Thyroid Hormone Mediated Endocrine Regulation" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Michael Ailion (University of Washington, USA) "The EARP Complex Controls Cargo Sorting to Dense-Core-Vesicles" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Feeding into Autophagosomes and Lysosomes |
| Discussion Leader: Indira Mysorekar (Washington University School of Medicine, USA) |
9:00 am - 9:25 am | Sharon Tooze (Francis Crick Institute, United Kingdom) "Molecular Pathways and Vesicular Traffic During Autophagosome Formation" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Roberto Zoncu (University of California, Berkeley, USA) "The Lysosome in Nutrient Sensing and Cellular Growth Control" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Ana Maria Cuervo (Albert Einstein College of Medicine, USA) "Chaperone-Mediated Autophagy: Crossing the Lysosomal Membrane Becomes Challenging in Neurodegeneration" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Jason Mills (Washington University School of Medicine in St. Louis, USA) "Mist 1: A Single Transcription Factor that Is Necessary/Sufficient to Block Autophagy and Build a Secretory Cell" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Cristina Mazuski (Washington University in St. Louis, USA) "Decoding the Firing Patterns of SCN VIP Neurons" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Stephanie Duval (Institut de Recherche Clinique de Montreal (IRCM), Université de Montréal, Canada) "Defining the Functions of the Type II-Transmembrane Proteins GPP130 and casc4: Shedding at Common and Distinct Sites by PC7 and Furin" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Gholson Lyon (Cold Spring Harbor Laboratory, USA) "The X-Linked Ogden Syndrome Involving NAA10 and the Amino-Terminal Acetylation of Proteins in Human Biology and Disease" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | To Image Trafficking and Secretion |
| Discussion Leader: Ronald Holz (University of Michigan Medical School, USA) |
7:30 pm - 7:55 pm | Edwin Levitan (University of Pittsburgh, USA) "Presynaptic Dense-Core Vesicle Traffic: Effects of Neuron Type, Activity and Injury" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Matthijs Verhage (Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands) "Trafficking and Fusion of Dense Core Vesicles in Mammalian Neurons" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Patrik Verstreken (VIB, KU Leuven, Belgium) "Sleep Defects in Parkinson's Disease" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Edwin Chapman (Howard Hughes Medical Institute / University of Wisconsin-Madison, USA) "Ca2+ Sensors that Regulate the Release of Hormones from the Anterior Pituitary" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |