Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Targeting of Substrates to the Membrane Transport Machinery
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Molecular Chaperones and Protein Folding in the Cell"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mechanisms of Protein Targeting to Cellular Membranes"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Molecular Topology of the Transit Peptide During Chloroplast Protein Import"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Structure and Mechanisms of Protein Translocases
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Structural Insights into Protein Translocation Mechanisms Using Cryo-Electron Microscopy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"An Update on Tail-Anchored Targeting from a Structural Perspective"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Structure of the Core of the Type Three Secretion System Export Apparatus"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Evaluating the Functional Pore Size of Chloroplast TOC and TIC Protein Translocons: Import of Folded Proteins"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Disposition of E. coli SecA Bound to Lipid Vesicles"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Transport and the Interface of Protein Transport with Transport-Associated Machinery
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Protein Import into Chloroplasts and Its Regulation by the Ubiquitin-Proteasome System"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Mitochondrial Machineries for Protein Translocation and Assembly"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Functions of Ribosome-Bound Factors in the Yeast Saccharoymces cerevisiae "
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Dissecting the Function of Components Comprising the Plasmodium Translocon of Exported P"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Protein Insertion and Dynamics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"From Chaperones to the Membrane with a BAM!"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Mitochondrial Protein Transport Along the Presequence Pathway"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Pore-Forming Activity of the Pseudomonas aeruginosa Type III Secretion System Translocon Alters the Host Epigenome"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Structural Studies of the Mitochondrial Sorting and Assembly Machinery Complex"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Protein Dimerization Can Fix a Labile Membrane Protein Topology"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"How the Charge Balance Rule Governs Membrane Protein Topology"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Origins and Diversity of Membrane Transport Machinery
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Substrate Recognition by the BAM Complex"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Mitochondria Protein and Lipid Transport"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"The Role of TPR Domains of Plant Mitochondrial Oxa Proteins"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Dual Sec Translocases and Function of GET3-Related Factors Within Chloroplasts"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Assembly of Membrane Transport Complexes
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Receptor-induced Toxin Delivery During Bacterial Contact-Dependent Growth Inhibition (CDI)"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Transport of Proteins by the Twin Arginine Protein Transport Pathway"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Mechanisms of Tail-Anchored Protein Triage"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Molecular Pathways of Mitochondrial Outer Membrane Protein Degradation"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Analysing the Assembled Tat Translocase"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Membrane Trafficking of the Accessory Sec Transport Substrate and Machinery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Transport in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Protein Transport in the Curli or Bacterial Amyloid Assembly Pathway"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Can We Learn New Tricks from an Old Dog? Glycosome Biogenesis in an Ancient Eukaryote"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Aberrant Secretory Proteins in Human Diseases"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Targeting and Insertion of Pxa1, the Yeast Homologue of ALDP, a Peroxisomal ABC Transporter Important for Human Health"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Response of Protein Transport to Stress
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"The Mitochondrial UPR and Mitochondrial Protein Import Efficiency"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Malaria Parasites Co-Opt Human Hsp70 for Protein Translocation"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"The TAM: A Nanomachine Responsible for the Assembly of Complex Outer Membrane Proteins"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Analysis of the Function of Beta-Barrel Assembly Machinery in the Bacteria by New Method EMM Assembly Assay"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Single Molecule Studies of the Bacterial Translocase SecA"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Systems/High-Throughput Approaches to Understanding Protein Transport and Organelle Biogenesis
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Two Distinct Anionic Lipid Dependent Steps During Posttranslational Translocation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Small Molecule Modulators for Mitochondrial Protein Import"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"Stabilizing Forces Holding the Nuclear Pore Ring Assembly"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"A High-Throughput Secretion Assay Reveals a Chaperone-Independent Type III Secretion Pathway"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure