Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Aging and Glycobiology: New Frontiers in Exocrine Biology
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Evolution of the 'Molecular Frontier', the Sialome of the Sialome"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Longevity Mechanisms: Lessons from the Naked Mole Rat and Other Long-Lived Mammals"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Exocrine Gland Development: Cell Plasticity, Fate and Morphology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Submandibular Gland Development: Insights from Single Cell Transcriptomic Analysis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"From Discovery of Sweat Gland Stem Cells to Future Sweat Gland Regeneration"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Fgf10/Fgfr2b Signaling Plays Distinct Roles in Submandibular Gland Morphogenesis, Homeostasis and Repair"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"CFTR Acts as an Essential Regulator of Exocrine Gland Morphogenesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Molecular Influences During Cell Fate Changes Towards Secretory Units"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Irradiation Acutely Suppresses Intracellular Ca2+ Signaling in Mice Submandibular Gland"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Acinar-to-Ductal Metaplasia in Salivary Gland Acinar Cells upon Stress or Injury"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Engineering the Glandular Epithelium
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Lineage Hierarchies and Plasticity in Epithelial Stem Cells"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Creating 3D Tubes from 2D Primordia: The Role of Fkh (Drosophila FoxA) and Its Downstream Targets"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Engineering the Endocrine Pancreas"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"The Physical and Chemical Contributions to the Self-Organization (and Disorganization) of the Human Mammary Gland"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regenerating a Secretory Organ: Current Models and Outcomes
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Potential of Endogenous Cells in Salivary Gland Regenerative Strategies"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Regeneration of Secretory Glands After Cancer Therapy: Towards Clinical Application?"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"PKCd Regulates Chromatin Conformation and DNA Double Stranded Break Repair in Response to Irradiation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Probing the Role of the CRTC1-MAML2 Fusion Oncogene-Induced lncRNA LINC00473 in Human Mucoepidermoid Carcinoma"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Regenerating the Lacrimal Gland: Current Progress and Future Challenges"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Wnt/TCF Control of Glandular Myoepithelial Stem Cell Regenerative Responses in the Airway"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Regeneration of Salivary Glands In Vivo Using Double Layer Cell Sheets"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Current Concepts in Salivary Cancer: From Etiology to Treatments
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Myb-NFIB Interactions in Adenoid Cystic Carcinoma"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Mucoepidermoid Carcinoma: CRTCal Links Between CREB and MYC Signaling"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Perineural Invasion in Cancer: A Dynamic Process"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Therapeutic Targeting of Salivary Gland Cancer Stem Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mucins and Salivary Proteins
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Amylase Copy Number Analysis in Several Mammalian Lineages Reveals Convergent Adaptive Bursts Shaped by Diet"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Salivary Proteome of Individuals with Moebius Syndrome"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Human Salivary Proteome Wiki"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Mapping Quantitative Differences in Human Salivary Gland Secretions by Dried Saliva Spot Sampling and NanoLC-MS/MS"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Influence of Salivary Mucins on Oral Streptococci Physiology"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"A Role for Salivary Proteins in Taste and Feeding"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Loss of Galnt3 Results in Altered Glycosylation of the Major SMG Mucin Muc10"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Membrane Dynamics: Signaling and Function
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Functional Relevance of STIM Proteins: Tuning Store-Operated Ca2+ Entry and More"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"P2 Nucleotide Receptor Structure and Salivary Gland Function in Sjögren's Syndrome"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Ion Channel Control of Dynamic Release of BMP"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Modeling Saliva Secretion in Three Dimensions: How Much Detail Do You Really Need?"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Autoimmune Disease and Aging: Models and Outcomes
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genetic Studies of Sjogren's Syndrome Highlight Disease Heterogeneity According to Ancestry and Phenotypic Features"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Interplay of Antigen Presenting Cells and Aging and the Development of Dry Eye"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Excessive Cholesterol Synthesis Causes Sjögren's Syndrome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Cdc42 Negatively Regulates Endocytosis During Apical Membrane Maintenance in Live Animals"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Genomic Characterization of Sjogren's Syndrome"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Dissecting Ubiquitin-Dependent Stem Cell-Fate Decisions During Human Development and Disease"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Calcium Signaling via CRAC Channels in the Pathogenesis of Sjögren's Syndrome"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Metabolic Regulation and Adaptation
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:40 pm
"Metabolic Adaptation in Physiology and Disease"
8:40 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure