Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Tissue Repair and Neoplasia
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
"From One Niche to Another: Human Stem/Progenitor Cells for Salivary Gland Regeneration"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 9:10 pm
"Back to the Future: Links Between Tissue Repair, Reprogramming to an Embryonic-Like State, and Cancer"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Ex-Vivo Development and Re-Engineering of Tissues
9:00 am - 9:20 am
"Cell Plasticity and Tissue Remodeling in Exocrine Glands"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Biofabrication and Today’s Regenerative Engineering"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Cleaning up the Neighborhood: Remediating Fibrosis to Facilitate Regeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Progenitor Niches in the Developing Pancreas: Regulation of Cell Fate and Beyond"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A Human iPSC-Derived Salivary Gland Organoid Model for Diabetic Salivary Gland Dysfunction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Early Epithelial-Mesenchymal Interactions Controlling Development of the Salivary Gland Mesenchyme"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Outspread Limits Myosin II Activity to Control Epithelial Tube Architecture"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Break Free From Locked Fate: Targeted Regeneration of Radiation Damaged Salivary Epithelium"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer and Radiation Impact in Exocrine Tissues
7:30 pm - 7:50 pm
"CRTCal Links Between Development and Salivary Tumor Progression"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"PKCδ and Radioprotection: The Role of the Mitochondria in DNA Damage and Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Pre-Clinical Models for the Determination of Chemoresistance in Salivary Gland Adenoid Cystic Carcinoma"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Role of Macrophages in Murine Radiation Induced Salivary Gland Damage"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Saliva, the Oral Microbiota and Taste
9:00 am - 9:25 am
"How Bugs Stick to Spit: Glycan Recognition at the Saliva-Microbiome Interface"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Leveraging Metaproteomics to Investigate Saliva and the Oral Microbiome"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Salivary Proteins Alter Both Oral and Post-Oral Responding to Taste Stimuli"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"A Cross-Sectional Observational Study of Sicca Patients with Salivary Autoantibodies Defines a Potential New Phenotype of Sjögren’s Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Evaluation of Oral Care Method using MA-T Technology for the Oral Microbiota of High-Risk Patients"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Understanding the Role of Myoepithelial Cells in Salivary Gland Regeneration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Novel Trigeminal Sensory Innervation of the Submandibular Gland: Trpv1+ Neurons Detect Changes in Ductal pH"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Purinergic Receptors as Therapeutic Targets for Salivary Gland Dysfunction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exocrine Glands of Eye and Airways
7:30 pm - 7:50 pm
"Effects of Age and Stress on Meibomian Gland Growth and Differentiation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Sebaceous Glands During Homeostasis and Regeneration"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Dynamics of the Airway Immune Niche and its Role in Regulating Gland Development"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Aging Mouse Lacrimal Glands: Uncovering Shared Features and Individual Heterogeneity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Epithelial and Mesenchymal Progenitor Cells in Normal and Inflamed Human Lacrimal Glands"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Innovative Treatments for Hyposalivation: A Multifaceted Approach to Restoring Saliva Production"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Sowing Seeds in Arid Lands: Challenges in Cell-Based Therapies for Radiation-Induced Xerostomia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Tissue-Resident Salivary Gland Macrophages Prime Epithelial Progenitor Cells to Regenerate Tissue"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Generation of Salivary Gland Organoids from Pluripotent Stem Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dissection of Salivary Glands by Autoantibody Profile in Sjögren's Syndrome Reveals Common and Distinct T-Cell Subsets and Fibroblast-Mediated Inflammation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Spatial Mapping and 3D Bioprinted Tumoroids to Uncover Molecular Targets in Salivary Gland Mucoepidermoid Carcinoma in Southeast Asia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Identifying Acinar Cell Fate Modulators for Regenerating Salivary Glands in Sjögren’s Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exocrine Tissue-Related Aging, Metabolism, and Senescence
7:30 pm - 7:50 pm
"Exploring the Immune Cell Landscape and Sex Differences in Aging Salivary Glands"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lipid Dysregulation in the Aged Lacrimal Gland"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Environmental Changes associated with Radiation-Induced Salivary Gland Dysfunction"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Metmorfin for Diabetes in Sjögren's Disease"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Clinical Trials and Autoimmune Diseases
9:00 am - 9:20 am
"Genetics and Genomics of Sjögren’s Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Sjögren’s Disease Endotypes: Towards Precision Medicine"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Calcium Channels Mediate Salivary Gland Function Locally and Systemically"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Transplantation of Autologous Stem Cells for Post-Radiotherapy Regeneration of the Submandibular Gland (RESTART): Preliminary Phase I/II Study Results"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Efficacy of Low-Dose IL-2 Therapy in Stratified Subgroups of Primary Sjögren’s Syndrome Patients"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Long Covid in Patients with Sjögren’s Disease"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Results of a Phase 1, Open-Label, Dose-Escalation Study of Gene Therapy with AAV2-hAQP1 as Treatment for Grade 2 and 3 Radiation-Induced Late Xerostomia and Parotid Gland Hypofunction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Impact of Cellular Aging on Chronic Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Senescence of Salivary Gland Progenitor Cells in Sjögren’s Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:50 pm
"Cellular Senescence and Senolytics: The Path to Translation"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure