Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Perspectives in Adhesion and
Homeostasis |
| Discussion Leaders: Alpha Yap (The University of Queensland, Australia) and Christopher Chen (Boston University / Harvard University, USA) |
7:40 pm - 8:15 pm | Ian Macara (Vanderbilt University Medical Center, USA) "Unexpected Roles for Polarity Proteins in the Life and Death of Epithelial Cells" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:40 pm | Selected from Poster Abstracts: Madeleine Oudin (Massachusetts Institute of Technology, USA) "Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis During Metastatic Progression" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Jody Rosenblatt (Huntsman Cancer Institute, University of Utah, USA) "Mechanical Stretch Triggers Rapid Epithelial Cell Division Through the Stretch-Activated Channel Piezo 1" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | New Mechanisms in Cell Adhesion |
| Discussion Leader: Maddy Parsons (King's College London, United Kingdom) |
9:00 am - 9:25 am | William Weis (Stanford University, USA) "Force-Dependent Molecular Interactions in Adherens Junction Assembly" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Vinay Swaminathan (National Heart, Lung, and Blood Institute, NIH, USA) "Actin Retrograde Flow Orients and Aligns Activated, Ligand-Engaged Integrins in Focal Adhesions" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected from Poster Abstracts: Ben Goult (University of Kent, United Kingdom) "The Emerging Role of Talin as a Mechanosensitive Signalling Platform" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Nicholas Brown (University of Cambridge, United Kingdom) "Integrating Adhesome Components into a Functional Machine" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Satyajit Mayor (National Centre for Biological Sciences, India) "Local Membrane Organization and Integrin Signaling" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Alessandra Cambi (Radboud University Medical Center, The Netherlands) "Nanoscale Architectures and Mesoscale Dynamics of Mechanosensory Podosomes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Myosin and Adhesion: Its Roles as Force Generator and Scaffold |
| Discussion Leader: Kris DeMali (University of Iowa, USA) |
7:30 pm - 7:55 pm | John Hammer (National Heart, Lung, and Blood Institute, NIH, USA) "Mixing and Matching Myosins to Drive Functional Diversity" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Margaret Gardel (The University of Chicago, USA) "A Mechanochemical Feedback to Regulate Cell Elasticity" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Vivian Tang (University of Illinois at Urbana-Champaign, USA) "Propagating Cortical Actomyosin-Generated Tension to Intercellular Adhesion Complex by Myosin-1c" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Colleen Skau (National Institutes of Health, USA) "An FMN2-Mediated Perinuclear Actin/Adhesion System Protects Against DNA Damage During Confined Cell Migration" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advances in Adhesion Signaling |
| Discussion Leader: Tony Koleske (Yale University, USA) |
9:00 am - 9:25 am | Ann Miller (University of Michigan, USA) "Regulation of Localized RhoA Activity and Cell-Cell Junction Remodelling in Dividing Epithelial Cells" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jay Groves (University of California, Berkeley, USA) "Mechanical Aspects of Signaling at Cell-Cell Junctions" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected from Poster Abstracts: Rishita Changede (Mechanobiology Institute, National University of Singapore, Singapore) "Nascent Integrin Adhesions Form on All Matrix Rigidities After Integrin Activation" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Hilary Ashe (University of Manchester, United Kingdom) "Enhancement of the BMP Pathway by Integrin Signalling in Drosophila" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Valerie Horsley (Yale University, USA) "Epithelial and Stromal Players in Skin Tissue Adhesion and Matrix Deposition" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Yusuke Toyama (Mechanobiology Institute, National University of Singapore, Singapore) "Tension-Dependent Vinculin Dynamics at Adherens Junction During Cell Boundary Oscillation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inside-Out Integrin Signaling: Revisiting a Controversy |
| Discussion Leader: Nicholas Brown (University of Cambridge, United Kingdom) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | David Calderwood (Yale University, USA) "How Important Is Inside-Out Signaling in Non-Hemopoeitic Cells?" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Martin Humphries (University of Manchester, United Kingdom) "Primordial Connections Between the Adhesion Nexus and Cell Proliferation" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Guy Tanentzapf (University of British Columbia, Canada) "Regulation of Integrin-Mediated Adhesion in Tissue Development and Homeostasis" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Adhesion and Tissue Homeostasis |
| Discussion Leader: Erin Cram (Northeastern University, USA) |
9:00 am - 9:25 am | Jay Humphrey (Yale University, USA) "Mechanoregulation of Matrix in Vascular Homeostasis and Disease" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Anna Huttenlocher (University of Wisconsin-Madison, USA) "Chemokines and Bidirectional Migration" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected from Poster Abstracts: Michael Smutny (Institute of Science and Technology Austria, Austria) "E-Cadherin-Dependent Friction Force Is a Major Driver of Tissue Morphogenesis in Zebrafish Development" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | John Wallingford (University of Texas at Austin, USA) "Pushing and Pulling: Understanding Cell Movement in Vertebrate Embryos" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Didier Stainier (Max Planck Institute for Heart and Lung Research, Germany) "Signaling, Cell Polarity and Adhesion During Cardiac Trabeculation" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Jocelyn McDonald (Kansas State University, USA) "Detachment Versus Cohesion: Novel Roles for PDZ-GEF and Rap1 During Collective Cell Migration" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | New Approaches to Integrate Across Biological Scales |
| Discussion Leader: Anand Asthagiri (Northeastern University, USA) |
7:30 pm - 7:55 pm | Celeste Nelson (Princeton University, USA) "Adhesions and Forces in Tissue Origami" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Virgile Viasnoff (Mechanobiology Institute, National University of Singapore, Singapore) "Control of Cell-Cell Contact Polarization by Mechanical Forces" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Christopher Chen (Boston University / Harvard University, USA) "Forces, Adhesions and Mechanotransduction in a Multicellular Context" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Disease: Adhesion and Its Discontents |
| Discussion Leader: Andrew Gladden (University of Texas MD Anderson Cancer Center, USA) |
9:00 am - 9:25 am | Peter Friedl (Radboud University Medical Center, The Netherlands) "Balancing Cell-Cell Interactions and Tissue Mechanics During Cancer Invasion" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Corinne Albiges-Rizo (Institut Albert Bonniot, Université Joseph Fourier / CNRS, INSERM, France) "Cell Contractility and Tissue Integrity" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:25 am | Selected from Poster Abstracts: Edna Cukierman (Fox Chase Cancer Center, Temple Health, USA) "Integrins in Epithelial Cancer Desmoplastic-to-Homeostatic Stroma Remodeling" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Martin Schwartz (Yale School of Medicine, USA) "Mechanotransduction in Vascular Health and Disease" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Weilan Ye (Genentech Inc., USA) "Modulating Integrin a5b1 Adhesive Property to Alter Drug Delivery and Lymphocyte Trafficking" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Xiaoyang Wu (University of Chicago, USA) "ACF7 Regulates Cell/Cell Junctions in Intestinal Epithelium" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Systems Approaches to Quantitative Analysis |
| Discussion Leader: Brenton Hoffman (Duke University, USA) |
7:30 pm - 7:55 pm | Valerie Weaver (University of California, San Francisco, USA) "Signaling in the 3rd Dimension: A Biophysical Perspective" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Alexander Mogilner (Courant Institute of Mathematical Sciences, New York University, USA) "Quantitative Adhesion Dynamics in Spontaneous and Induced Cell Motility Initiation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Xavier Trepat (Institute for Bioengineering of Catalonia (IBEC), Spain) "Epithelial Tissues as Active Materials Controlled by Cell-Cell Forces" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |