Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Insights on Old Pathways
7:40 pm - 8:25 pm
"Cancer Therapy Resistance: A Cell Biologist’s Perspective"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Regulation of Multicellularity in Choanoflagellates: An Evolutionary Perspective on Adhesion"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Adhesion Assembly and Disassembly
9:00 am - 9:25 am
"Mechanochemical Feedback and Signaling at the Epithelial Adherens Junction"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Desmosomes in Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Tumor Suppressive, Non-Canonical Notch1 Regulation of Epithelial Adherens Junctions and Mitogenic Signaling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Non-Junctional Cadherin in Regulating Actomyosin and Cortical Dynamics"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Desmosome Regulates the Junctional Interface and Actomyosin Dynamics During Apoptotic Cell Extrusion"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Alpha-Catenin Integrates Cytoskeletal Networks at Cardiomyocyte Adherens Junctions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Matrix Adhesion Assembly and Disassembly
7:30 pm - 7:55 pm
"Un Menage à Trois, Controlling Integrin Activation and Clustering by Talin and Kindlin"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Src and Focal Adhesion Signaling Dynamics"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Cytoskeletal Dynamics, Adhesion Assembly and Force"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Mechanical Regulation of RNA Localization Contributes to Cell Migration"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanical Regulation of Adhesion
9:00 am - 9:25 am
"Mechanical Homeostasis of the Extracellular Matrix"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Dynamics of Force Transduction at Single Integrin Complexes in Living Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Tension-Dependent Regulation of Mammalian Hippo Signaling Through LIMD1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Mechanotransduction Mechanisms at Cadherin Adhesions"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Mechanical Coupling of β2 Integrins to the Actin Cytoskeleton by a Molecular Clutch Drives Phagocytosis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Detecting Vinculin Load-Dependent Protein Recruitment to Focal Adhesions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Orchestrating Adhesion and Migration
7:30 pm - 7:55 pm
"Building the Body Plan: The Miracle of Morphogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Force Loading Rate as a Fundamental Magnitude in Mechanosensing"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Invasion Mechanisms in Metastasis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Interplay Between Caveolae and Junctional Mechanics"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adhesion and Tissue Remodeling
9:00 am - 9:25 am
"Regulation of Cell-Cell Junctions During Tissue Remodeling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"The Physical and Cellular Basis of Branching Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Multiscale Model Predicts Increasing Focal Adhesion Size with Decreasing Stiffness in Fibrous Matrices"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Coupling of Adhesive and Metabolic Pathways at Cell-Cell Junctions"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"The Polarity Protein aPKCi: A New Key Player of Basal Cell Extrusion, an Emergent Mechanism for Early Tumor Cell Dissemination"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Harnessing Actin Polymerization to Maintain Epithelial Sheets"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell-Matrix, Cell-Cell and Growth Factor Receptor Cross-Talk
7:30 pm - 7:55 pm
"Role of Cell-Cell Adhesion, Merlin and ERM Proteins in EGFR Distribution"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Regulation of TGFb Signaling and Fibrogenesis by Adhesion and Matrix"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Cell-Matrix Crosstalk in Cancer and Pluripotency"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Tumor Invasion Through Hyaluronic Acid Matrices Is Mediated by CD44-Dependent Microtentacles"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolving Concepts of Adhesion Signaling and Cancer Progression
9:00 am - 9:25 am
"The Varied Roles of Adhesions During Steps of Metastasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"MAP4K4, an Integrin-FERM Regulator in Cell-Cell Adhesion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"A Rab40b:Cullin-5 Interaction Regulates Elplin Levels to Control Stress Fiber and Focal Adhesion Formation and Affect Cell Cell Migration and Invasion"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Big Data Approaches to Cancer Migration"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Swiprosin1 Links Rab21-Containing Vesicles with the Actin Cytoskeleton to Drive Integrin Transport in Breast Cancer Cells"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Deciphering the Talin Code: Understanding Mechanotransduction Using Structural Mechanobiology"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical Applications of Adhesion Modulation
7:30 pm - 7:55 pm
"An Update on Anti-Integrin Therapeutic Programs"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Adhesion Signals as Cancer Targets"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Collagen Fibril Architecture Regulates Cell Adhesion, Metabolic Stress and Collective Migration"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Integrins in Inflammation and Fibrosis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure