Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Protein Quality Control and Aging
7:40 pm - 8:20 pm
"Proteostasis Function and Dysfunction: The Delicate Art of Maintaining a Healthy Proteome"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Monitoring Translation in Space and Time with Ribosome Profiling"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Chaperone Action in Folding and Disaggregation of Proteins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"How Do J-Proteins Get Hsp70 to Do So Many Different Things?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Chaperone Functions in Protein Folding and Proteostasis Maintenance"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"A New Twist in the Mechanism of the GroEL/GroES Chaperonin System"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Translocation Mechanism of the Hsp104 Disaggregase Determined by Cryo-EM"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Small Molecules that Control Cell Survival Pathways Through Inhibiting Hsp70"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Molecular Mechanisms to Maintain Cellular Redox Homeostasis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:20 pm
General Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sensing and Signaling: the Ribosome and Beyond
7:30 pm - 7:50 pm
"Ribosome Associated Protein Quality Control"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Ribosome-Associated Protein Quality Control (RQC)"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Aggregation-Prone Proteins that Require Ssb1 and Ssb2 Molecular Chaperones Are Not Translated Slower than Non-Aggregation-Prone Proteins"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"The Dynamic Landscape of Molecular Chaperones Across Tissues"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Structure and Function of an Essential Co-Chaperone of Hsp90"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Quality Control and Disease
9:00 am - 9:20 am
"Proteasome Dysfunction in Polyglutamine Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Contribution of Aging to Neurodegeneration: From DNA Damage to Protein Aggregates"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The Intertwined Roles of RNA Misregulation and Protein Aggregation in ALS and FTD"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Surviving Protein Quality Control Failure in Cells and Organisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Uncovering the Cellular Response to Mechanical Stress: What Can a Worm Teach Us About Traumatic Brain Injury?"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Evolution of an Intricate J-Protein Network Driving Protein Disaggregation in Eukaryotic Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Transcriptional Response to Stress Is Pre-Wired by Promoter and Enhancer Architecture"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:20 pm
General Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Aggregates, Assemblies and Depots
7:30 pm - 7:50 pm
"Organizing Living Matter in Stressed Cells: Phase Transitions as a Survival Strategy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"How Cells Use Quinary Regulation to Sense and Respond to Stress"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"P-Bodies, RNP Granules and Protein Quality Control"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Acid-Induced Chloride Accumulation Leads to Cytotoxic Protein Aggregation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Quality Control and Aggregation in the Aging Vertebrate Proteome"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Homeostasis in the Endoplasmic Reticulum
9:00 am - 9:20 am
"Protein Folding and Quality Control via the Hsp70 System"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of ER Homeostasis by Redox Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"ER Stress Response During the Cell Cycle"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Early Events in the Endoplasmic Reticulum Unfolded Protein Response"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Regulation of ENaC (Epithelial Sodium Channel) by the ER Lumenal Chaperone, GRP170"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Glial Regulation of ER Stress Resistance and Longevity"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"TRAPPC13 Modulates Autophagy and the Response to Golgi Stress"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:20 pm
General Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteinopathies: Aging and Defense Strategies
7:30 pm - 7:50 pm
"Role of Polyphosphate in Amyloidogenic Processes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Resetting Organismal Proteostasis Through Epigenetic and Mitochondrial Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Hsp90 and Its Co-Chaperones Regulate ALS-Related Proteinopathies"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Limiting the Buffer Function of HSP90 Markedly Enhances Tumor Immunogenicity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"C. elegans Model for Prion-Like Spreading of a-Syn Reveals New Genetic Modifiers of Cell to Cell Transmission"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Protein Triage and Degradation
9:00 am - 9:20 am
"How the Proteasome Selects Proteins for Degradation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of Protease vs. Co-Chaperone Activity of a Metacaspase - Turning an Executioner into a Protector"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Substrate Recognition by the Proteasome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Sensory Experience and Learning Modulate the Expression of Molecular Chaperones in C. elegans "
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Filamentous Aggregates Are Disassembled by the Proteasome in a Ubiquitin-Independent Manner"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Heritable Switches in Conformation and Transcriptional Regulation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Hsp12 and Trehalose: Necessary and Sufficient Desiccation Stress Effectors"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:20 pm
General Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Control of Stress Protein Expression
5:30 pm - 5:50 pm
"Molecular Chaperones Regulate the Chromatin Landscape - Is It Time to Move?"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
"Hsf1 Restructures the Yeast Genome in Response to Heat Shock"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"The Atypical Regulation of Heat Shock Factors in Disease"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Defining the Regulatory Interaction of Ssa1/Hsp70 with Hsf1"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Essential Function and Dynamic Regulation of Yeast Heat Shock Factor"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure