Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Protein Aggregation In Vitro Biochemistry and Organismal Ageing
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Sticky Misfolds: How Amyloid Formation Fuels Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Regulation of Aging and Longevity"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Stress Response Networks
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Regulation of the Heat Shock Transcription Factor Hsf1 by the Hsp70 Chaperone Network"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Interindividual Variation in Proteostasis Shapes Phenotypic Traits and Stress Resilience"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Selective Proteome Remodeling Upon Lipid Exhaustion via RNA Helicase Condensation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"New Insights into Old Neurons' Proteostasis Network"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Crosstalk Between Hsp90s and J-Domain Proteins is Maintained Throughout Evolution"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Reduced Protein Influx into the ER Activates IRE1"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Kinetics and Mechanisms of Transcriptional Reprogramming During Stress and Differentiation"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
General Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
ATP Independent Chaperones Machines
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Roles of RNA Quadruplexes and SERF Proteins in Protein Folding"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Chaperone Proteins Evolved to be Meddlesome"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"The Evolution of Coassembly in sHSPs"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"PIAS4 Conjugates SUMO2/3 Chains to TDP-43 to Prevent Stress-Induced Aggregation"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chaperones, Protein Condensation and Spatial Sequestration
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Amyloid Disaggregation by the Hsp70 Chaperone"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"TPR Domain Proteins and J Proteins Alter Sequestration and Toxicity of Misfolded Proteins"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Amyloids and Condensates: Can They Coexist"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Circadian Clocks are Modulated by Compartmentalized Oscillating Translation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Polyglutamine Tolerance In Human Evolution: From The Speech Gene To Neurodegenerative Diseases"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Interplay of Chaperone Function and Regulatory Ubiquitination in Phase-Separated Nucleolar Protein Quality Control"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"A Genetic Modifier that Modulates Neurodegeneration Caused by Defective Protein Quality Control"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
General Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Control and Protein Homeostasis
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Dynamics of Chaperone Function in situ "
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"HSF1-Induced Endo-siRNAs Protect Nascent Hsp Pre-mRNA Splicing and Integrity During the C. Elegans Heat Shock Response"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Regulation of Nascent Polypeptide Degradation at Stalled Ribosomes"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"In Vivo Functions of the Chaperonin TRiC/CCT"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chaperones Interacting with Degradation Machines
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Chaperone-Mediated and Endosomal Microautophagy: Linked by a Chaperone"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Phase Separation of Initiation Hubs on Cargo is a Trigger Switch for Selective Autophagy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Lysosome Damage and Repair in Quiescent Ce"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Divergence in Proteostasis Strategies Underpins the Stress Resilience of Senescent Human Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:10 am
"Cross-Talk Between Chaperone and Autophagy Networks Regulates Proteostasis"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Site-Specific Hydrophobicity Completes YF Motif Activation of the 20S Proteasome"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"The Selective Degradation of Protein Aggregates by Autophagy"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
General Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Session in Memory of Dr. Dan Hebert: ER-UPR in Folding and Diseases
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"UFMylation and Proteostasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"A Chaperone Condensate Orchestrates Protein Folding in the Endoplasmic Reticulum"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"In vivo Implications of FICD-Mediated Protein AMPylat"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
General Discussion
9:10 pm - 9:25 pm
"The Sweet Life Studying Glycans, UGGT, and the ER"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Protein Quality Control Networks in Cancer and Ageing
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Targeting the Stress Network in the Tumor Microenvironment"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Delineating Mechanisms of Cancer Cell Stress Resilience"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"HSF1 Remodels Mitochondrial Biogenesis and Function in Cancer Cells via TIMM17A"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Role of the Hsp90 Molecular Chaperone in Aging"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"HSP90's Role in Ecological Sensing and the Accumulation of Cryptic Genetic Variation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Hikeshi and the Role of HSP70 in Nuclear Proteostasis"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Drug Targeting of PQC Networks
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Exploring Chaperone Protein-Protein Interactions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Repurposing Screen Identifies ISR Activating Compounds that Promote Adaptive Mitochondria Remodeling in MFN2-deficient Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Talk Selected from GRS
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"The Hsp70 Chaperone Code Elicits Multipoint Control of the Cellular Response to Replication Stress"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure