Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Systems Biology Methods to Solve Aging
Discussion Leader: Jesse Poganik (Brigham and Women's Hospital, Harvard Medical School, United States)
3:15 pm - 3:45 pm
Uri Alon (Weizmann Institute of Science, Israel)
"Systems Biology Approach to Solve Aging"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Translatable Biomarkers of Aging
Discussion Leader: Thomas Jackson (Environmental Protection Agency, United States)
5:30 pm - 5:45 pm
Mahdi Moqri (Harvard University / Stanford University , United States)
"Multi-Omic Biomarkers of Aging as Targets for Cellular Rejuvenation"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Eszter Zita Szatmári (Hun-Ren Institute for Computer Science and Control, Hungary)
"Unique Patterns in Amino Acid Sequences of Aging-Related Proteins"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Alexander LeNail (Massachusetts Institute of Technology, United States)
"Charting the Cellular Rejuvenation Landscape in Aging Neurons"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Genna Abdullah (University of Liverpool, United Kingdom)
"Multi-Omics Analysis of Neutrophils from People with Frailty, Healthy Older and Healthy Younger People Identifies Impaired Regulation of Migration Associated with Aging"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Maria Fernandez (National Institute on Aging, National Institutes of Health, United States)
"Network Analysis of Life Course Trajectories Within the Study of Longitudinal Aging in Mice"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Andrew Graham (King's College London, United Kingdom)
"Liver X Receptor Agonism Rescues Hippocampus-Dependent Cognition Deficits in Aged Mice"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Data-Driven Models that Learn Aging Biology
Discussion Leader: Ognian Neytchev (University of Glasgow, United Kingdom)
9:00 am - 9:15 am
Baptiste Sadoughi (Arizona State University, United States)
"Within- and Among-Individual Heterogeneity in Aging in Multi-Tissue Epigenomic in Semi-wild Rhesus Macaques"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Thaís Lopes de Oliveira (Karolinska Institutet, Sweden)
"Effects from Medications on Functional Biomarkers of Aging in Three Longitudinal Studies of Aging in Sweden"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Alina Su (Generation Lab / Harvard Medical School, United States)
"Ovarian Clock with Rejuvenation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Oleksandra Soldatkina (Barcelona Supercomputing Center, Spain)
"Molecular and Histological Changes Across Female Reproductive Tissues During Human Menopausal Transition"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Zane Koch (University of California, San Diego, United States)
"Somatic Mutation as an Explanation for Epigenetic Aging"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Olga Vishnyakova (Genome Science Center, BC Cancer, Canada)
"Distance from Metabolomic Sweet Spots Predicts Lifespan and Healthspan"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Decoding Complex Aging Phenotypes with Physics-Based Models
Discussion Leader: Elena Sergeeva (Tufts University, United States)
1:30 pm - 1:45 pm
Todd Dowrey (Boston University, United States)
"Uncovering the Molecular Mechanisms of Exceptional Longevity Through iPSC-Based Modeling of Resiliency"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Glen Pridham (Dalhousie University, Canada)
"Network Dynamical Stability Analysis Captures Essential Age-Related Phenomena"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Naveh Raz (Weizmann institute of science, Israel)
"Human Aging Dynamics in the Light of a Stochastic Mechanistic Model"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes